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BACKGROUND: The European Society of Cardiology guidelines recommend an LDL-cholesterol (LDL-C) < 55 mg/dL for patients with established cardiovascular disease. While the Friedewald equation to estimate LDL-C is still widely used, the newer Martin-Hopkins equation has shown greater accuracy. OBJECTIVES: We aimed to assess: A) the proportion of patients reaching LDL-C goal and the therapies used in a tertiary center; B) the impact of using the Martin-Hopkins method instead of Friedewald's on the proportion of controlled patients. METHODS: A single-center cross-sectional study including consecutive post-myocardial infarction patients followed by 20 cardiologists in a tertiary hospital. Data was collected retrospectively from clinical appointments that took place after April 2022. For each patient, the LDL-C levels and attainment of goals were estimated from an ambulatory lipid profile using both Friedewald and Martin-Hopkins equations. A two-tailed p-value of < 0.05 was considered statistically significant for all tests. RESULTS: Overall, 400 patients were included (aged 67 ± 13 years, 77% male). Using Friedewald's equation, the median LDL-C under therapy was 64 (50-81) mg/dL, and 31% had LDL-C within goals. High-intensity statins were used in 64% of patients, 37% were on ezetimibe, and 0.5% were under PCSK9 inhibitors. Combination therapy of high-intensity statin + ezetimibe was used in 102 patients (26%). Applying the Martin-Hopkins method would reclassify a total of 31 patients (7.8%). Among those deemed controlled by Friedewald's equation, 27 (21.6%) would have a Martin-Hopkins' LDL-C above goals. CONCLUSIONS: Less than one-third of post-myocardial infarction patients had LDL-C within the goal. Applying the Martin-Hopkins equation would reclassify one-fifth of presumably controlled patients into the non-controlled group.

FUNDAMENTO: As diretrizes da Sociedade Europeia de Cardiologia recomendam um nível de colesterol LDL (LDL-C) < 55 mg/dL para pacientes com doença cardiovascular estabelecida. Embora a fórmula de Friedewald ainda seja amplamente utilizada para estimar o LDL-C, a fórmula mais recente de Martin-Hopkins mostrou maior precisão. OBJETIVOS: Nosso objetivo foi avaliar: A) a proporção de pacientes que atingiram a meta de LDL-C e as terapias utilizadas em um centro terciário; B) o impacto da utilização do método de Martin-Hopkins em vez do método de Friedewald na proporção de pacientes controlados. MÉTODOS: Estudo transversal monocêntrico, incluindo pacientes consecutivos pós-infarto do miocárdio, acompanhados por 20 cardiologistas, em um hospital terciário. Os dados foram coletados retrospectivamente de consultas clínicas realizadas após abril de 2022. Para cada paciente, os níveis de LDL-C e o atingimento das metas foram estimados a partir de um perfil lipídico ambulatorial, utilizando as fórmulas de Friedewald e Martin-Hopkins. Um valor-p bicaudal < 0,05 foi considerado estatisticamente significativo para todos os testes. RESULTADOS: Foram incluídos 400 pacientes (com 67 ± 13 anos, 77% do sexo masculino). Utilizando a fórmula de Friedewald, a mediana de LDL-C sob terapia foi de 64 (50-81) mg/dL, e 31% tinham LDL-C dentro da meta. Estatinas de alta intensidade foram usadas em 64% dos pacientes, 37% estavam em uso de ezetimiba e 0,5% estavam em uso de inibidores de PCSK9. A terapia combinada de estatina de alta intensidade + ezetimiba foi utilizada em 102 pacientes (26%). A aplicação do método de Martin-Hopkins reclassificaria um total de 31 pacientes (7,8%). Entre aqueles considerados controlados pela fórmula de Friedewald, 27 (21,6%) teriam LDL-C estimado por Martin-Hopkins acima da meta. CONCLUSÕES: Menos de um terço dos pacientes pós-infarto do miocárdio apresentaram LDL-C dentro da meta. A aplicação da fórmula de Martin-Hopkins reclassificaria um quinto dos pacientes presumivelmente controlados no grupo de pacientes não controlados.

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Resumo Fundamento: As diretrizes da Sociedade Europeia de Cardiologia recomendam um nível de colesterol LDL (LDL-C) < 55 mg/dL para pacientes com doença cardiovascular estabelecida. Embora a fórmula de Friedewald ainda seja amplamente utilizada para estimar o LDL-C, a fórmula mais recente de Martin-Hopkins mostrou maior precisão. Objetivos: Nosso objetivo foi avaliar: A) a proporção de pacientes que atingiram a meta de LDL-C e as terapias utilizadas em um centro terciário; B) o impacto da utilização do método de Martin-Hopkins em vez do método de Friedewald na proporção de pacientes controlados. Métodos: Estudo transversal monocêntrico, incluindo pacientes consecutivos pós-infarto do miocárdio, acompanhados por 20 cardiologistas, em um hospital terciário. Os dados foram coletados retrospectivamente de consultas clínicas realizadas após abril de 2022. Para cada paciente, os níveis de LDL-C e o atingimento das metas foram estimados a partir de um perfil lipídico ambulatorial, utilizando as fórmulas de Friedewald e Martin-Hopkins. Um valor-p bicaudal < 0,05 foi considerado estatisticamente significativo para todos os testes. Resultados: Foram incluídos 400 pacientes (com 67 ± 13 anos, 77% do sexo masculino). Utilizando a fórmula de Friedewald, a mediana de LDL-C sob terapia foi de 64 (50-81) mg/dL, e 31% tinham LDL-C dentro da meta. Estatinas de alta intensidade foram usadas em 64% dos pacientes, 37% estavam em uso de ezetimiba e 0,5% estavam em uso de inibidores de PCSK9. A terapia combinada de estatina de alta intensidade + ezetimiba foi utilizada em 102 pacientes (26%). A aplicação do método de Martin-Hopkins reclassificaria um total de 31 pacientes (7,8%). Entre aqueles considerados controlados pela fórmula de Friedewald, 27 (21,6%) teriam LDL-C estimado por Martin-Hopkins acima da meta. Conclusões: Menos de um terço dos pacientes pós-infarto do miocárdio apresentaram LDL-C dentro da meta. A aplicação da fórmula de Martin-Hopkins reclassificaria um quinto dos pacientes presumivelmente controlados no grupo de pacientes não controlados.

Abstract Background: The European Society of Cardiology guidelines recommend an LDL-cholesterol (LDL-C) < 55 mg/dL for patients with established cardiovascular disease. While the Friedewald equation to estimate LDL-C is still widely used, the newer Martin-Hopkins equation has shown greater accuracy. Objectives: We aimed to assess: A) the proportion of patients reaching LDL-C goal and the therapies used in a tertiary center; B) the impact of using the Martin-Hopkins method instead of Friedewald's on the proportion of controlled patients. Methods: A single-center cross-sectional study including consecutive post-myocardial infarction patients followed by 20 cardiologists in a tertiary hospital. Data was collected retrospectively from clinical appointments that took place after April 2022. For each patient, the LDL-C levels and attainment of goals were estimated from an ambulatory lipid profile using both Friedewald and Martin-Hopkins equations. A two-tailed p-value of < 0.05 was considered statistically significant for all tests. Results: Overall, 400 patients were included (aged 67 ± 13 years, 77% male). Using Friedewald's equation, the median LDL-C under therapy was 64 (50-81) mg/dL, and 31% had LDL-C within goals. High-intensity statins were used in 64% of patients, 37% were on ezetimibe, and 0.5% were under PCSK9 inhibitors. Combination therapy of high-intensity statin + ezetimibe was used in 102 patients (26%). Applying the Martin-Hopkins method would reclassify a total of 31 patients (7.8%). Among those deemed controlled by Friedewald's equation, 27 (21.6%) would have a Martin-Hopkins' LDL-C above goals. Conclusions: Less than one-third of post-myocardial infarction patients had LDL-C within the goal. Applying the Martin-Hopkins equation would reclassify one-fifth of presumably controlled patients into the non-controlled group.

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Introducción: La fiebre chikungunya (FCHIK) es una enfermedad febril transmitida por mosquitos, que en el niño tiene manifestaciones clínicas diferentes, dependiendo del grupo de edad. Objetivo: el presente trabajo tiene el propósito de identificar las características clínicas y evolutivas de la FCHIK en pacientes ≤15 años, que acudieron al Instituto de Medicina Tropical (IMT). Materiales y método: estudio observacional, descriptivo retrospectivo, basado en revisión de historias clínicas de pacientes de 0 y 15 años, que consultaron al IMT, entre noviembre/2022 y marzo/ 2023, con diagnóstico de FCHIK. Resultados: de 2050 pacientes febriles que consultaron al IMT entre noviembre/2022 y marzo/2023, 301 fueron casos de FCHIK, 10,6% (32/301) requirió hospitalización, de estos el 62,5% (20/32) era ≤1 año. La presencia de vómitos (p<0.0001.OR= 5,5 IC95% 2.2-13.2), dolor abdominal (p<0.0001.OR=40.5,5 IC95% 4.5-364.3); erupción maculo-papular-ampollar p<0.008. OR=3.5, IC95% 1.3 - 9.1), fue significativamente más frecuente en los hospitalizados. El 37.5% (12/32) fue hospitalizado en UCI y 15,6% (5/32) requirió ARM, 18.7%(6/32) presentó miocarditis; 15.6%(5/32) encefalitis, y 3.1%(1/32) encefalitis y miocarditis. No se registraron óbitos. Conclusiones: La décima parte de los pacientes con FCHIK requirieron hospitalización, de estos más de la mitad fueron <1 año. Las manifestaciones clínicas más frecuentes fueron fiebre, exantema, vómitos, irritabilidad, artralgias, lesiones ampollares. La leucopenia fue significativamente más frecuente en ≤1 año. La edad <3 meses, así como vómitos, exantema vesículo-ampollar, presencia de choque, irritabilidad, convulsiones, dolor abdominal y dificultad respiratoria se asociaron significativamente al requerimiento de hospitalización. Las complicaciones más frecuentes fueron el choque, la miocarditis y la encefalitis.

Introduction: Chikungunya fever (CHKF) is a febrile disease transmitted by mosquitoes, which presentes different clinical manifestations in children, depending on their age group. Objective: to describe the clinical and outcome characteristics of CHKF in patients ≤15 years old, who presented to the Institute of Tropical Medicine (ITM). Materials and methods: this was a retrospective, descriptive and observational study, based on the review of medical records of patients between 0 and 15 years of age, who were evaluated at the ITM, between November/2022 and March/2023, who were diagnosed with CHKF. Results: of 2050 febrile patients who consulted at the ITM between November/2022 and March/2023, 301 were cases of CHKF, 10.6% (32/301) required hospitalization, of which 62.5% (20/32) were ≤ 1 year of age. The presence of vomiting (p<0.0001, OR= 5.5, 95% CI 2.2-13.2), abdominal pain (p<0.0001, OR=40.5.5, 95% CI 4.5-364.3); maculo-papular-bullous rash (p<0.008, OR=3.5, 95% CI 1.3 - 9.1), was significantly more frequent in hospitalized patients. 37.5% (12/32) were hospitalized in the ICU and 15.6% (5/32) required ARM, 18.7% (6/32) presented myocarditis; 15.6%(5/32) encephalitis, and 3.1%(1/32) had both encephalitis and myocarditis. No deaths were registered. Conclusions: One tenth of the patients with CHKF required hospitalization, of which more than half were <1 year of age. The most frequent clinical manifestations were fever, rash, vomiting, irritability, arthralgia, and bullous lesions. Leukopenia was significantly more frequent in those ≤1 year of age. Age <3 months, as well as vomiting, vesicular-bullous rash, shock, irritability, seizures, abdominal pain, and respiratory distress were significantly associated with the need for hospitalization. The most frequent complications were shock, myocarditis and encephalitis.

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BACKGROUND AND PURPOSE: Metabolic and vascular dysfunction are common features of obesity. Aryl hydrocarbon receptor (AhR) regulates lipid metabolism and vascular homeostasis, but whether vascular AhR are activated in obesity or have a protective and/or harmful effects on vascular function in obesity are unknown. Our study addresses whether AhR activation contributes to obesity-associated vascular dysfunction and the mechanisms involved in these AhR effects. EXPERIMENTAL APPROACH: Male AhR KO (Ahr-/- ) and WT mice were fed either control or a HF (high-fat) diet for 10 weeks. Metabolic and inflammatory parameters were measured in serum and adipose tissue. Vascular reactivity (isometric force) was evaluated using a myography. Endothelial NOS (eNOS) and AhR protein expression was determined by western blot, Cyp1A1 and Nos3 gene expression by RT-PCR and.NO production was quantified by DAF fluorescence. KEY RESULTS: HF diet increased total serum HDL and LDL, as well as vascular AhR protein expression and proinflammatory cytokines in the adipose tissue. HF diet decreased endothelium-dependent vasodilation. AhR deletion protected mice from HF diet-induced dyslipidaemia, weight gain and inflammatory processes. HF diet-induced endothelial dysfunction was attenuated in Ahr-/- mice. Vessels from Ahr-/- mice exhibited a greater NO reserve. In cultured endothelial cells, lysophosphatidylcholine (LPC) a major component of LDL and oxidized LDL [oxLDL]) reduced Nos3 gene expression and NO production. Antagonism of the AhR inhibited LPC effects on endothelial cells and induced decreased endothelium-dependent vasodilation. CONCLUSION AND IMPLICATIONS: AhR deletion attenuates HF diet-induced dyslipidaemia and vascular dysfunction by improving eNOS/NO signalling. Targeting AhRs may prevent obesity-associated vascular dysfunction.

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ABSTRACT Objective: To analyze the pre- and postoperative spinopelvic parameters and global sagittal balance of patients with adolescent idiopathic scoliosis (AIS) divided into 3 groups (Group 1 - thoracic arthrodesis, Group 2 - thoracolumbar arthrodesis, and Group 3 - lumbar arthrodesis), observing differences in these two moments and whether the parameter values are maintained or not over a period of up to 2 years following surgery. Methods: We analyzed the radiographs from a single-center database of 99 patients who underwent arthrodesis with posterior instrumentation. Pelvic incidence, pelvic version, sacral slope, lumbar lordosis, thoracic kyphosis, and sagittal vertical axis values were measured in the pre- and postoperative radiographies of each patient. Results: The parameters of pelvic incidence, pelvic version, sacral slope, and sagittal vertical axis did not show statistically significant differences among the 3 groups. There was a difference in preoperative lumbar lordosis between the 3 groups (p = 0.049). Thoracic kyphosis showed differences both in the pre- (p = 0.015) and postoperative (p = 0.042) values, in addition to demonstrating a relationship of dependence between the pre- and postoperative values in the final statistical analysis. Conclusion: The evaluation of the parameters analyzed shows that the study groups have similar values of individual balance, with the exception of thoracic kyphosis and lumbar lordosis, which are measurements that depend on the surgical technique and compensatory mechanisms, but remained within normal ranges. These factors allow the surgeon to be attentive to both the coronal and sagittal planes when planning the correction in order to achieve the equilibrium of the trunk in addition to correction of the deformity. Level of Evidence IIIA: Comparative retrospective study.

RESUMO Objetivo: Analisar parâmetros espino-pélvicos e equilíbrio sagital de pacientes com escoliose idiopática do adolescente (EIA) no pré e pós-operatório em três grupos (grupo 1 - artrodese torácica, grupo 2 toracolombar e grupo 3 - artrodese lombar), observando diferenças nesses dois momentos e se os parâmetros são mantidos ou não por um período de até dois anos de pós-operatório. Métodos: Foram avaliadas radiografias de 99 pacientes de um banco de dados de um único centro, que foram submetidos a artrodese por via posterior. Foram aferidos valores da incidência pélvica, versão pélvica, inclinação sacral, lordose lombar, cifose torácica e eixo vertical sagital nas radiografias pré e pós-operatória. Resultados: Os parâmetros de incidência pélvica, versão pélvica, inclinação sacral e do eixo vertical sagital não apresentaram diferenças estatisticamente significantes nos três grupos. A lordose lombar apresentou diferença entre os três grupos no pré-operatório (p = 0,049). A cifose torácica apresentou diferenças tanto no pré (p = 0,015) quanto no pós-operatório (p = 0,042), além de demonstrar relação de dependência nos valores do pré e pós na análise estatística final. Conclusões: A avaliação dos parâmetros analisados mostra que os grupos estudados apresentam valores semelhantes de equilíbrio do indivíduo, com exceção da cifose torácica e lordose lombar que são medidas dependendo da técnica cirúrgica e dos mecanismos compensatórios, porém mantendo-se dentro da faixa normal. Esses fatores permitem ao cirurgião ficar atento no planejamento da correção tanto no plano coronal quanto no plano sagital para conseguir, além da correção da deformidade, o equilíbrio do tronco. Nível de Evidência IIIA; Estudo retrospectivo comparativo.

RESUMEN Objetivo: Analizar los parámetros espino-pélvicos y el equilibrio sagital de pacientes con escoliosis idiopática del adolescente (EIA) en el pre y postoperatorio divididos en 3 grupos (grupo 1 - artrodesis torácica, grupo 2 - toracolumbar y grupo 3 - artrodesis lumbar), observando las diferencias en estos dos momentos y si los parámetros se mantienen o no durante un periodo de hasta 2 años en el postoperatorio. Métodos: Se evaluaron las radiografías de 99 pacientes de una base de datos de un solo centro, a quienes se les realizó artrodesis por vía posterior. Se midieron los valores de incidencia pélvica, versión pélvica, inclinación sacra, lordosis lumbar, cifosis torácica y eje vertical sagital en las radiografías pre y postoperatorias de cada paciente. Resultados: Los parámetros de incidencia pélvica, versión pélvica, inclinación sacra y eje vertical sagital no presentaron diferencias estadísticamente significativas en los 3 grupos. La lordosis lumbar presentó una diferencia entre los 3 grupos en el preoperatorio (p = 0,049). La cifosis torácica presentó diferencias tanto en el pre (p = 0,015) como en el postoperatorio (p = 0,042), además de presentar una relación de dependencia entre los valores del pre y postoperatorios en el análisis estadístico final. Conclusiones: La evaluación de los parámetros analizados muestra que los grupos estudiados presentan valores de equilibrio individual similares, con excepción de la cifosis torácica y la lordosis lumbar, que se miden en función de la técnica quirúrgica y de los mecanismos compensatorios, pero manteniéndose dentro del rango normal. Estos factores permiten al cirujano estar atento a la hora de planificar la corrección tanto en el plano coronal como en el sagital, para lograr, además de corregir la deformidad, el equilibrio del tronco. Nivel de evidencia IIIA; Estudio retrospectivo comparativo.

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BACKGROUND: This study compared the quality of marginal sealing in the gingival wall of class II preparations of two low-shirinkage resins of the bulk fill type with a conventional resin isolated or associated with a glass ionomer cement (GIC). MATERIAL AND METHODS: 40 human molars were divided into 4 groups and 80 occlusal-mesial and occlusal-distal restorations were performed with the following materials: SureFil SDR flow, Filtek Bulk Fill Posterior, Z250 resins and Riva Light Cure GIC. 40 restorations were evaluated in Scanning Electron Microscopy (SEM) with Elemental Microanalysis Spectrometry (EDS) initially and the remainder after a period of 6 months of aging in a 37 ± 5°C oven. An average of the silver penetration at each restoration was obtained in the two evaluations and the results were statistically analyzed in a descriptive and inferential way, through the paired t-Student and one-way ANOVA F-test. RESULTS: There were no significant statistical differences between the materials with respect to silver nanoinfiltration, except for the Bulk Fill Posterior/3M ESPE resin compared to the GIC and conventional resin in the final evaluation. CONCLUSIONS: The low shrinkage resins showed a similar behavior in relation to the marginal sealing quality observed in the GIC or composite resin with the incremental technique, also presenting the advantage of simplicity in the technique of confection of the restorations and reduction of the time of work. Key words:Resin composites, Bulk fill, dental restorations, marginal quality, adhesion.

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Resumen Introducción. La plaquetopenia severa representa un reconocido signo de alarma del dengue. Objetivo. Determinar la relación entre el recuento de plaquetas y severidad del dengue en niños. Metodología. Niños menores de 15 años hospitalizados con el diagnóstico de dengue entre los años 2007-2018 fueron evaluados en el recuento de plaquetas y severidad de la enfermedad. Los pacientes fueron divididos en 2 grupos, según que el recuento de plaquetas fuera mayor o menor de 100.000/mm3. Resultados. Ochocientos ochenta y dos pacientes hospitalizados con dengue fueron incluidos en el estudio, con una edad media 9,7 ± 4,6 años, e igual distribución de sexo: 437 (49,5%) del sexo femenino y 445 (50,5%) del sexo masculino. El 62,4% (550 pts) presentaron plaquetas ≤100.000/mm3. No hubo diferencias en la frecuencia de fiebre (99% vs 98%), cefalea (54% vs 62%), exantema (38% vs 34%) y mialgias (42% vs 47%) entre aquellos pacientes con plaquetas 100.000/mm3. Sin embargo, la frecuencia de sangrados (28% vs 26%, p3 veces lo normal) (10% vs 2%; p<0,0001; OR=7,41; 95% IC 2,93-18,70), la presencia de extravasación (49% vs 4%; p<0,0001; OR 27,7; 95% IC 14,86-51,57), e ingreso a UTI (11% vs 0,4%, p<0,0001; OR 41,29; 95% IC 5,69-299,33) fue mayor en los pacientes con plaquetas <100.000/mm3. Conclusiones. El presente estudio muestra que la severidad del dengue es mayor en pacientes con dengue con plaquetas <100.000/mm3 y que las complicaciones están influenciadas por la misma.

Abstract Introduction. Severe platelet disease is a recognized warning sign of dengue. Objective. To determine the relationship between platelet count and dengue severity in children. Methodology. Children younger than 15 years hospitalized with the diagnosis of dengue between 2007-2018 were evaluated for the platelet`s count and severity of the disease. The patients were divided into 2 groups, according to whether the count o platelets was greater or less than 100,000 / mm3. Results. Eight hundred eighty two hospitalized patients with dengue were included in the study, with a mean age of 9.7 ± 4.6 years, and the same sex distribution: (437 (49.5%) female and 445 (50.5%) male. Sixty-two % (550 pts) presented platelets ≤100,000 / mm3. There were no differences in the frequency of fever (99% vs. 98%), headache (54% vs. 62%), rash (38% vs. 34%) and myalgia (42% vs. 47%) among those patients with platelets 100,000 / mm3. However, the frequency of bleeding (28% vs 26%, p 3 times normal) (10% vs 2%; p <0.0001; OR = 7.41, 95% CI 2.93-18.70), the presence of extravasations (49% vs. 4%; p <0.0001; OR 27.7, 95% CI 14.86-51.57), and admission to ICU (11% vs. 0.4%, p <0.0001; OR 41.29, 95 % CI 5.69-299.33) it was higher in patients with platelets <100,000 / mm3. Conclusions. The present study shows that dengue severity is higher in dengue patients with platelets <100,000 / mm3 and those complications are influenced by it.

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