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The aim of this study was to investigate the association between maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder (ASD). We conducted a case-control study with children and adolescents diagnosed with ASD and neurotypical individuals. The data were collected using a semi-structured questionnaire administered during interviews with the children's mothers or guardians. The following variables were analyzed: child sex and age; maternal and parental age; use of medicines before and during pregnancy; classes of medicines used during pregnancy; maternal and paternal smoking; maternal and paternal drinking; maternal and paternal illicit drug use. The data were analyzed using logistic regression and crude and adjusted odds ratios (OR). After adjustment, the results showed an association between maternal use of antipyretics/pain killers during pregnancy (OR = 2.26; 95%CI 1.29-3.95; p < 0.040) and ASD. No association was found between maternal and paternal smoking, drinking and illicit drug use before and during pregnancy and ASD. The findings suggest that the development of ASD is influenced by environmental factors.
O presente estudo objetivou investigar a associação entre o TEA e o uso materno e paterno de medicamentos, tabaco, álcool e drogas ilícitas. Trata-se de um estudo caso-controle realizado com crianças e adolescentes diagnosticados com TEA e indivíduos neurotípicos. Os dados foram colhidos por meio de entrevista com as mães ou responsáveis. Foram analisadas as variáveis sexo e idade das crianças/adolescentes; idade dos pais; uso de medicamentos antes e durante a gestação; classes de medicamentos usados na gestação; tabagismo materno e paterno; etilismo materno e paterno; uso de drogas ilícitas pelos pais. Para a análise das informações, utilizou-se o modelo de regressão logística, além da razão de chances (OR) bruta e ajustada. Os resultados mostraram que, após os ajustes, foi encontrada associação entre o uso materno na gestação de antitérmicos/analgésicos (OR = 2,26; IC95% 1,29-3,95; p < 0,040) com o TEA. Já o uso de tabaco, álcool e drogas ilícitas materno e paterno, antes e durante a gestação, não apontou relação com o TEA. Os dados encontrados sugerem que existe influência de fatores ambientais no desenvolvimento do TEA.
Assuntos
Transtorno do Espectro Autista , Drogas Ilícitas , Humanos , Gravidez , Criança , Feminino , Adolescente , Fatores de Risco , Estudos de Casos e Controles , Transtorno do Espectro Autista/epidemiologia , Transtorno do Espectro Autista/etiologia , Fumar/epidemiologiaRESUMO
INTRODUCTION: Retinoblastoma is a malignant tumor with a high cure potential when proper therapy is used. The purpose of this paper is to report the clinical features and outcomes of patients with retinoblastoma who were treated with a combination of local and systemic chemotherapy-based protocols. METHOD: We retrospectively studied patients treated with systemic chemotherapy plus local treatment between 2003 and 2015 with a follow-up ≥2 years. We correlated clinical and pathological characteristics with decimal visual acuity (VA) and death. RESULTS: Among 119 patients, 60% had unilateral disease (UNI), and 52% were male. The median presentation age was 19.5 months, 10% had a positive family history, and the most frequent sign was leukocoria (68.8%). Advanced disease was more frequent in eyes with UNI (98.4%) than in eyes with bilateral retinoblastoma (BIL: 55.3%). Enucleation was performed in 97% of UNI eyes and in 55.8% of BIL eyes. The overall globe salvage was 26.6%, 44.25% of BIL eyes. Bilateral enucleation was required in 5%. High-risk pathologic features occurred in 50% and 37% of eyes enucleated without and with neoadjuvant chemotherapy, respectively. High-risk features were related to the presence of goniosynechiae in the pathologic specimen and were more frequent in children younger than 10 months or older than 40 months. Extraocular disease was present in 5% of patients, and the death rate related to metastasis of the tumor was 8%. The final VA was ≥ 0.7 in 72.8% and ≥0.1 in 91% of BIL patients. CONCLUSIONS: Treatment of retinoblastoma with conservative systemic-based chemotherapy was associated with an excellent survival rate (92%). Albeit the low overall globe salvage rate, in BIL patients, approximately half the eyes were conserved, and a satisfactory functional visual result was achieved The evaluated protocol is an important treatment option, especially in developing countries.
Assuntos
Neoplasias da Retina , Retinoblastoma , Criança , Humanos , Masculino , Lactente , Feminino , Retinoblastoma/diagnóstico , Retinoblastoma/epidemiologia , Retinoblastoma/terapia , Brasil/epidemiologia , Estudos Retrospectivos , Terapia Neoadjuvante , Neoplasias da Retina/diagnóstico , Neoplasias da Retina/epidemiologia , Neoplasias da Retina/terapiaRESUMO
Resumo O presente estudo objetivou investigar a associação entre o TEA e o uso materno e paterno de medicamentos, tabaco, álcool e drogas ilícitas. Trata-se de um estudo caso-controle realizado com crianças e adolescentes diagnosticados com TEA e indivíduos neurotípicos. Os dados foram colhidos por meio de entrevista com as mães ou responsáveis. Foram analisadas as variáveis sexo e idade das crianças/adolescentes; idade dos pais; uso de medicamentos antes e durante a gestação; classes de medicamentos usados na gestação; tabagismo materno e paterno; etilismo materno e paterno; uso de drogas ilícitas pelos pais. Para a análise das informações, utilizou-se o modelo de regressão logística, além da razão de chances (OR) bruta e ajustada. Os resultados mostraram que, após os ajustes, foi encontrada associação entre o uso materno na gestação de antitérmicos/analgésicos (OR = 2,26; IC95% 1,29-3,95; p < 0,040) com o TEA. Já o uso de tabaco, álcool e drogas ilícitas materno e paterno, antes e durante a gestação, não apontou relação com o TEA. Os dados encontrados sugerem que existe influência de fatores ambientais no desenvolvimento do TEA.
Abstract The aim of this study was to investigate the association between maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder (ASD). We conducted a case-control study with children and adolescents diagnosed with ASD and neurotypical individuals. The data were collected using a semi-structured questionnaire administered during interviews with the children's mothers or guardians. The following variables were analyzed: child sex and age; maternal and parental age; use of medicines before and during pregnancy; classes of medicines used during pregnancy; maternal and paternal smoking; maternal and paternal drinking; maternal and paternal illicit drug use. The data were analyzed using logistic regression and crude and adjusted odds ratios (OR). After adjustment, the results showed an association between maternal use of antipyretics/pain killers during pregnancy (OR = 2.26; 95%CI 1.29-3.95; p < 0.040) and ASD. No association was found between maternal and paternal smoking, drinking and illicit drug use before and during pregnancy and ASD. The findings suggest that the development of ASD is influenced by environmental factors.
RESUMO
ABSTRACT Introduction: Acute promyelocytic leukemia currently presents an excellent chance of cure with protocols based on all-trans-retinoic acid (ATRA) and anthracycline or only differentiation agents. However, high early mortality rates continue to be reported Methods: Between 2000 and 2018, patients were enrolled and retrospectively analyzed by medical records. A modified AIDA protocol, with a 1-year shortening of the treatment duration, reduction in the number of drugs and a strategy to reduce early mortality by the postponement of the initiation of anthracyclines were employed. Overall and event-free survival rates and toxicity were analyzed Results: Thirty-two patients were enrolled, of whom 56% were female, with a median age of 12 years and 34% belonged to the high-risk group. Two patients had the hypogranular variant and three had another cytogenetic alteration, in addition to the t(15;17). The median start of the first anthracycline dose was 7 days. There were two early deaths (6%) due to central nervous system (CNS) bleeding. All patients achieved molecular remission after the consolidation phase. Two children relapsed and were rescued by arsenic trioxide and hematopoietic stem cell transplantation. The presence of disseminated intravascular coagulation (DIC) at diagnosis (p = 0.03) was the only factor with survival impact. The five-year event-free survival (EFS) was 84% and 5-year overall survival (OS) was 90% Conclusion: The survival results were comparable to those found in the AIDA protocol, with a low rate of early mortality in relation to the Brazilian reality.
RESUMO
INTRODUCTION: Acute promyelocytic leukemia currently presents an excellent chance of cure with protocols based on all-trans-retinoic acid (ATRA) and anthracycline or only differentiation agents. However, high early mortality rates continue to be reported METHODS: Between 2000 and 2018, patients were enrolled and retrospectively analyzed by medical records. A modified AIDA protocol, with a 1-year shortening of the treatment duration, reduction in the number of drugs and a strategy to reduce early mortality by the postponement of the initiation of anthracyclines were employed. Overall and event-free survival rates and toxicity were analyzed RESULTS: Thirty-two patients were enrolled, of whom 56% were female, with a median age of 12 years and 34% belonged to the high-risk group. Two patients had the hypogranular variant and three had another cytogenetic alteration, in addition to the t(15;17). The median start of the first anthracycline dose was 7 days. There were two early deaths (6%) due to central nervous system (CNS) bleeding. All patients achieved molecular remission after the consolidation phase. Two children relapsed and were rescued by arsenic trioxide and hematopoietic stem cell transplantation. The presence of disseminated intravascular coagulation (DIC) at diagnosis (pâ¯=â¯0.03) was the only factor with survival impact. The five-year event-free survival (EFS) was 84% and 5-year overall survival (OS) was 90% CONCLUSION: The survival results were comparable to those found in the AIDA protocol, with a low rate of early mortality in relation to the Brazilian reality.
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Resumo: Introdução: Os universitários de Ciências da Saúde se tornaram especialmente afetados pela pandemia do vírus Sars-CoV-2. As angústias intrinsicamente relacionadas à Covid-19 foram somadas aos impactos referentes às mudanças acontecidas nas instituições acadêmicas, particularmente a mudança para o ensino on-line, uma metodologia que pode gerar desconforto aos estudantes, além de vários obstáculos relacionados ao ensino e à aprendizagem, o que pode ter repercussões traumáticas importantes na saúde mental dessa população. Objetivo: Este estudo teve como objetivo verificar a carga mental provocada pela pandemia da Covid-19, como um evento traumático ao ponto de desencadear transtornos psiquiátricos, como o transtorno do estresse pós-traumático (Tept), em universitários. Método: Trata-se de um estudo transversal e quantitativo, com orientação analítico-descritiva, mediante preenchimento de formulário digital anônimo, iniciado após prévia aprovação do Comitê de Ética em Pesquisa. Os sujeitos foram estudantes de Ciências Biológicas e da Saúde de uma universidade estadual localizada na Região Sudeste do Brasil. A amostra foi constituída por 618 estudantes. Resultado: Foram respondidos 618 formulários pelos estudantes que pertenciam aos cursos de Educação Física (28,8%), Medicina (25,4%), Odontologia (18,1%), Ciências Biológicas (15,2%) e Enfermagem (12,5%). A presença de sintomas de estresse pós-traumático verificados pela Escala de Impacto do Evento-Revisada (IES-R) obteve prevalência de 32,7% (n = 202) entre os estudantes universitários das Ciências Biológicas e da Saúde. Conclusão: Houve impacto significativo na saúde mental dos universitários com presença de sintomas depressivos, ansiedade e estresse acima dos encontrados na literatura científica, e, consequentemente, constatou-se alta na prevalência do Tept.
Abstract: Introduction: Health Sciences university students were especially affected by the Sars-CoV-2 virus pandemic. The anxieties intrinsically related to Covid-19 were added to the impacts related to the changes that have taken place in academic institutions, particularly the change to online teaching, a methodology that can generate discomfort for students, in addition to several obstacles related to teaching and learning, which can have important traumatic effects on the mental health of this population. Objective: To assess the mental health burden caused by the COVID-19 pandemic, as a traumatic event capable of triggering psychiatric disorders, such as Post-Traumatic Stress Disorder (PTSD), in university students. Methods: This is a cross-sectional and quantitative study, of analytical-descriptive nature, carried out by filling out an anonymous digital form, initiated after prior approval by the Research Ethics Committee. The subjects were students of Biological and Health Sciences at a State University located in the southeastern region of Brazil. The sample consisted of 618 students. Results: 618 forms were answered by students attending the courses of Physical Education (28.8%), Medicine (25.4%), Dentistry (18.1%), Biological Sciences (15.2%) and Nursing (12.5%). The presence of post-traumatic stress symptoms assessed by the Impact of Event Scale - Revised (IES-R) obtained a prevalence of 32.7% (n = 202) among university students from Biological and Health Sciences courses. Conclusions: There was a significant impact on the mental health of university students, with the presence of depressive symptoms, anxiety and stress above those found in the scientific literature and, consequently, a high prevalence of PTSD.
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Esta revisão integrativa analisa o papel do agente comunitário de saúde (ACS) e os fatores associados ao trabalho desenvolvido na Estratégia Saúde da Família (ESF). A busca de estudos foi realizada no portal da Biblioteca Virtual em Saúde (BVS), incluindo as bases de dados Medical Literature Analysis and Retrieval System Online (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Base de Dados em Enfermagem (Bdenf). Incluíram-se estudos primários publicados entre 2016 e 2021, com textos completos, nos idiomas português, inglês e espanhol. Excluíram-se protocolos, normas técnicas e outras revisões. Os estudos elegíveis foram avaliados na íntegra para a sumarização de dados e classificação dos níveis de evidências A busca inicial obteve 578 estudos. Destes, excluíram-se 44 duplicados, restando 534 para leitura de títulos e resumos. Foram selecionados 29 para leitura na íntegra, excluindo-se dez por não responderem à questão de pesquisa. A amostra foi constituída por 19 estudos. O trabalho do ACS baseia-se principalmente em ações de visita domiciliar, cadastramento e acompanhamento da população adstrita em seu território de atuação. Tal profissional contribui de forma significativa para a melhoria das condições de saúde da população, pois serve de elo entre a equipe de saúde e a comunidade, possibilitando maior acesso da população aos serviços ofertados pelo Sistema Único de Saúde (SUS).
This integrative review analyzes the role of community health agents (CHA) and factors associated with the work developed by the Family Health Strategy (FHS). Bibliographic search was conducted on the Virtual Health Library (VHL), including the Medical Literature Analysis and Retrieval System Online (MEDLINE), Latin American and Caribbean Health Sciences Literature (LILACS) and Base de Dados em Enfermagem (BDENF) databases. Primary studies published in Portuguese, English and Spanish between 2016 and 2021, and available in full were included. Protocols, technical standards, and other reviews were excluded. Eligible studies were assessed in full for data summarization and classification of the levels of evidence Initial search identified 578 studies, of which 44 duplicates were excluded. A total of 534 papers had their title and abstract read. Of these 29 were selected for full reading and 10 were excluded for not answering the research question, resulting in a final sample with 19 studies. CHA work consists mainly in home visits, registration, and monitoring of the population in their territory, contributing significantly to improve people's health conditions, since they serve as a link between the health team and the community, providing greater user access to Unified Health System (SUS) services.
Esta revisión integradora analiza el papel del agente comunitario de salud (ACS) y los factores asociados al trabajo desarrollado en la Estrategia de Salud Familiar (ESF). La búsqueda de estudios se realizó en el portal de Biblioteca Virtual en Salud (BVS), incluyendo las bases de datos Medical Literature Analysis and Retrieval System Online (MEDLINE), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) y Base de Datos en Enfermería (BDENF). Se incluyeron estudios primarios publicados entre 2016 y 2021, con textos completos en los idiomas portugués, inglés y español. Se excluyeron los protocolos, las normas técnicas y otras revisiones. Los estudios elegibles se evaluaron en su totalidad para sintetizar los datos y clasificar los niveles de evidencia La búsqueda inicial obtuvo 578 estudios. De estos, se excluyeron 44 duplicados, quedando 534 para la lectura de títulos y resúmenes. Se seleccionaron 29 para su lectura íntegra, excluyendo diez por no responder a la pregunta de investigación. La muestra estaba formada por 19 estudios. El trabajo de las ACS se basa principalmente en acciones de visita domiciliaria, registro y seguimiento de la población en su territorio de actuación. Ese profesional contribuye significativamente para la mejoría de las condiciones de salud de la población, pues sirve de enlace entre el equipo de salud y la comunidad, posibilitando un mayor acceso de la población a los servicios de salud ofrecidos por el Sistema Único de Salud (SUS).
Assuntos
Saúde da Família , Papel ProfissionalRESUMO
O objetivo deste estudo foi avaliar as propriedades psicométricas do Modified Checklist for Autism in Toddlers (M-Chat) em crianças de 24 a 36 meses de idade com (Grupo 1/n = 88) e sem (Grupo 2/n = 1116) o transtorno do espectro do autismo (TEA). Avaliou-se a consistência interna e estimou-se a sensibilidade, especificidade, valor preditivo positivo (VPP), valor preditivo negativo (VPN). Além disso, construiu-se a curva Receiver Operating Characteristic (ROC). Para avaliar a validade discriminante, comparou-se a proporção de falhas entre as crianças com e sem o TEA, utilizando o teste qui-quadrado ou teste Exato de Fisher. Comparou-se ainda o número de falhas segundo sexo, faixa etária e grupo do participante por meio do teste de Mann-Whitney. O M-Chat apresentou consistência interna elevada (0,78 e 0,86), reprodutibilidade satisfatória (Kappa de 0,6 a 0,79 e CCI = 0,87 e 0,89), alta sensibilidade (0,807 e 0,932), especificidade (0,927 e 0,706) e VPN (0,984 e 0,992), porém as estimativas do VPP (0,467 e 0,250) não foram satisfatórias. Quanto à validade discriminante, observou-se que a proporção de falhas foi significativamente maior no grupo de crianças com TEA. Observou-se também que o número de falhas foi maior entre as crianças do sexo masculino, com faixa etária de 25-36 meses e no grupo com TEA. A versão brasileira do M-Chat tem propriedades psicométricas adequadas no que se refere à confiabilidade, sensibilidade, especificidade, VPN e validade discriminante, o que torna recomendável sua aplicação para rastrear crianças com sinais do TEA.(AU)
This study aims to assess the psychometric properties of the instrument Modified Checklist for Autism in Toddlers (M-CHAT) in children from 24 to 36 months old with (Group 1/n = 88) and without (Group 2/n = 1116) Autism Spectrum Disorder (ASD). Internal consistency was evaluated and sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were estimated. Also, the Receiver Operating Characteristic (ROC) curve was generated. To evaluate the discriminant validity, the proportion of flaws among children with and without ASD was assessed by applying the Chi-square test or by the Exact Fisher test. The number of flaws based on sex, age group, and participant's group was also compared with the Mann-Whitney Test. The M-CHAT showed high internal consistency (0.78 and 0.86), satisfactory reproductivity (Kappa 0.60 and 0.79 and ICC = 0.87 and 0.89), high sensibility (0.807 and 0.932), specificity (0.927 and 0.706), and NPV (0.984 and 0.992); however, PPV estimates (0.467 and 0.250) were not satisfactory. Regarding the discriminant validity, the proportion of flaws was significantly higher in the group of children with ASD. Moreover, the number of flaws was larger among boys, in the age group 25-36 months, and in the group with ASD. The Brazilian version of M-CHAT has adequate psychometric properties concerning reliability, sensitivity, specificity, NPV and discriminant validity, which makes its application recommendable to track children with ASD signs.(AU)
Ese estudio tuvo como objetivo evaluar las propiedades psicométricas del Modified Checklist for Autism in Toddlers (M-CHAT) en niños de 24 a los 36 meses de edad con (grupo 1/n=88) y sin (grupo 2/n=1116) el trastorno del espectro autista (TEA). Fueron evaluadas la consistencia interna y estimadas la sensibilidad, especificidad, valor predictivo positivo (VPP), valor predictivo negativo (VPN). Además, se construyó la curva Receiver Operating Characteristic (ROC). Para evaluar la validad discriminante se comparó la proporción de los fracasos entre los niños con y sin TEA, utilizando el examen chi-cuadrado o la prueba exacta de Fisher. Se compararon también el número de fracasos según el sexo, edad y grupo de participantes por medio del teste Mann-Whitney. El M-CHAT presentó consistencia interna elevada (0,78 y 0,86), reproductividad satisfactoria (Kappa de 0,60 a 0,79 e CCI = 0,87 e 0,89), alta sensibilidad (0,807 e 0,932), especificidad (0,927 e 0,706) y VPN (0,984 e 0,992), pero las estimativas del VPP (0,467 e 0,250) no fueron satisfactorias. Acerca de la validad discriminante, se observó que la proporción de fallas fue significativamente mayor en el grupo de niños con TEA. El número de fracasos fue mayor entre los niños varones, de 25 a 36 meses de edad y no en el grupo con TEA. La versión brasileña del M-CHAT tiene propiedades psicométricas adecuadas en lo que concierne a la confiabilidad, sensibilidad, especificidad, VPN y validad discriminante, lo que hace que su aplicación sea recomendada para rastrear los niños con señales de TEA.(AU)
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Transtorno Autístico , Triagem , Sensibilidade e Especificidade , Estudo de Validação , Atenção Primária à Saúde , Psicologia , Política Pública , Sinais e Sintomas , Fala , Família , Criança , Desenvolvimento Infantil , Valor Preditivo dos Testes , Cognição , Comunicação , Fotofobia , Síndrome de Asperger , Agressão , Diagnóstico Precoce , Ecolalia , Educação Inclusiva , Emoções , Medicalização , Autocontrole , Análise do Comportamento Aplicada , Angústia Psicológica , Intervenção Psicossocial , Inclusão Social , Interação Social , Sistema Vestibular , Aprendizagem , NeurologiaRESUMO
The association between alcohol consumption by students with family conflicts, parental supervision and quality of relationships was investigated. A cross-sectional study was conducted with 1,265 adolescents from 21 schools. The Brazilian version of the Drug Use Screening Inventory/DUSI was used, and absolute and relative prevalence for categorical variables was estimated, while bivariate analyses and Pearson's Chi Square test were conducted. For the magnitude of the association between the dependent and independent variables, prevalence ratios were estimated using Poisson multivariate regression. There was an association between alcohol consumption and drug use by family members, frequent discussions and parental lack of awareness about adolescents' activities. Family supervision, a good relationship with parents/guardians, establishing an affective family bond and parents' knowledge about teenagers' whereabouts, were protective factors for alcohol use. The conclusion was that the high rate of schoolchildren who consume alcohol is worrying, liable to health complications in general, and a harmonized family relationship is fundamental. The implementation of measures of intervention between school and the Family Health Strategy, can contribute to the establishment of a protective bond.
Investigou-se a associação entre o consumo de álcool pelos escolares com os conflitos familiares, supervisão dos pais e qualidade dos relacionamentos. Estudo transversal realizado com 1.265 adolescentes de 21 escolas. Foi utilizada a versão brasileira do Inventário de Triagem do Uso de Drogas/DUSI e estimadas prevalências absolutas e relativas para variáveis categóricas, e conduzidas análises bivariadas: teste Qui Quadrado de Pearson. Para magnitude da associação entre a variável dependente e independentes foram estimadas razões de prevalências por meio deregressão multivariável de Poisson. Houve associação do consumo de álcool com uso de drogas por familiares, discussões frequentes e desconhecimento dos pais sobre o que os adolescentes fazem. Supervisão familiar, bom relacionamento com pais/responsáveis, estabelecimento de vínculo familiar afetivo e ciência dos pais acerca do que os adolescentes fazem e onde estão, foram fatores de proteção para uso de álcool. Concluiu-se que a alta taxa de escolares que consomem álcool é preocupante, passível de complicações da saúde na sua integralidade, sendo fundamental relação familiar harmonizada. A implementação de práticas interventivas entre escola e Estratégia de Saúde da Família, podem contribuir no estabelecimento de vínculo protetivo.
Assuntos
Conflito Familiar , Estudantes , Adolescente , Consumo de Bebidas Alcoólicas/epidemiologia , Criança , Estudos Transversais , Humanos , Pais , Instituições AcadêmicasRESUMO
Resumo Investigou-se a associação entre o consumo de álcool pelos escolares com os conflitos familiares, supervisão dos pais e qualidade dos relacionamentos. Estudo transversal realizado com 1.265 adolescentes de 21 escolas. Foi utilizada a versão brasileira do Inventário de Triagem do Uso de Drogas/DUSI e estimadas prevalências absolutas e relativas para variáveis categóricas, e conduzidas análises bivariadas: teste Qui Quadrado de Pearson. Para magnitude da associação entre a variável dependente e independentes foram estimadas razões de prevalências por meio deregressão multivariável de Poisson. Houve associação do consumo de álcool com uso de drogas por familiares, discussões frequentes e desconhecimento dos pais sobre o que os adolescentes fazem. Supervisão familiar, bom relacionamento com pais/responsáveis, estabelecimento de vínculo familiar afetivo e ciência dos pais acerca do que os adolescentes fazem e onde estão, foram fatores de proteção para uso de álcool. Concluiu-se que a alta taxa de escolares que consomem álcool é preocupante, passível de complicações da saúde na sua integralidade, sendo fundamental relação familiar harmonizada. A implementação de práticas interventivas entre escola e Estratégia de Saúde da Família, podem contribuir no estabelecimento de vínculo protetivo.
Abstract The association between alcohol consumption by students with family conflicts, parental supervision and quality of relationships was investigated. A cross-sectional study was conducted with 1,265 adolescents from 21 schools. The Brazilian version of the Drug Use Screening Inventory/DUSI was used, and absolute and relative prevalence for categorical variables was estimated, while bivariate analyses and Pearson's Chi Square test were conducted. For the magnitude of the association between the dependent and independent variables, prevalence ratios were estimated using Poisson multivariate regression. There was an association between alcohol consumption and drug use by family members, frequent discussions and parental lack of awareness about adolescents' activities. Family supervision, a good relationship with parents/guardians, establishing an affective family bond and parents' knowledge about teenagers' whereabouts, were protective factors for alcohol use. The conclusion was that the high rate of schoolchildren who consume alcohol is worrying, liable to health complications in general, and a harmonized family relationship is fundamental. The implementation of measures of intervention between school and the Family Health Strategy, can contribute to the establishment of a protective bond.