RESUMO

We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.

Assuntos

Fentanila/uso terapêutico , Morfina/uso terapêutico , Pancurônio/uso terapêutico , Estresse Fisiológico/tratamento farmacológico , beta-Endorfina/sangue , Feminino , Fentanila/farmacologia , Humanos , Recém-Nascido , Masculino , Morfina/farmacologia , Relaxamento Muscular/efeitos dos fármacos , Pancurônio/farmacologia , Estudos Prospectivos , Respiração Artificial/efeitos adversos , Doenças Respiratórias/terapia , Estresse Fisiológico/sangue , Estresse Fisiológico/etiologia