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BACKGROUND: Mortality from congenital heart disease has decreased considerably in the last two decades due to improvements in overall health care. However, there are barriers to access to healthcare in Latin America for this population, which could be related to factors such as healthcare system, policies, resources, geographic, cultural, educational, and psychological factors. Understanding the barriers to access to care is of paramount importance for the design and implementation of policies and facilitate the provision of care. AIM: The aim of the study was to investigate the perception of barriers to access to health care on parents/guardians of children with congenital heart disease in selected Latin American countries. METHODS: A descriptive, cross-sectional study, in which parents/guardians or primary caregivers of children with congenital heart disease was recruited to participate and surveyed. Once the informed consent process had been completed, a set of paper-based scales was used to collect data, namely socioeconomic and demographic information, the Barriers to Care for Children with Special Health Care Needs Questionnaire, and the General Health Questionnaire. RESULTS: In total, 286 participants completed the surveys, with an average age of 34.81 years and 73.4% being female. Mean score of overall barriers was 54.45 (minimum score 39, maximum score 195, higher scores show greater perception of barriers). In Mexico, the parents/guardians of children perceived fewer barriers to access (46.69), while Peru is the country where the most barriers were perceived (69.91). Nonpoor participants showed higher overall barrier perception scores (57.34) than poor participants (52.58). The regression analysis demonstrated the overall perception of barriers was positively associated with individual and social factors, such as educational level, contract status, household monthly income, and psychological well-being and with the country of the participants. CONCLUSIONS: Multiple factors are associated with the perception of barriers to accessing health care for children with congenital heart disease, including socioeconomic status, expectations, psychological well-being, and structural factors.

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The assessment of nutrition status, sarcopenia, and frailty holds significant relevance in the context of adult transplantation, as these factors are associated with an unfavorable prognosis; thus, transplant candidates must undergo a full nutrition assessment. Screening tools may be used to prioritize patients, this can be done using the Nutrition Risk Screening 2002 or Royal Free Hospital-Nutritional Prioritizing Tool. Subsequently, a thorough nutrition-focused physical examination should be conducted to evaluate clinical signs of nutrition deficiencies, fat and muscle loss, and fluid overload; dietary history and current intake must also be assessed. Apart from physical examination, specific testing for sarcopenia and frailty are recommended. For sarcopenia assessment, specifically for muscle quantification, the gold standard is the cross-sectional measurement of the muscle at L3 obtained from a computed tomography scan or magnetic resonance imaging; dual-energy x-ray absorptiometry is also a good tool especially when appendicular skeletal muscle index is calculated. Other more readily available options include phase angle from bioelectrical impedance or bioimpedance spectroscopy. In the sarcopenia assessment, muscle function evaluation is required, handgrip strength stands as the primary test for this purpose; this test is also part of the subjective global assessment and is included in some frailty scores. Finally, for frailty assessment, the Short Physical Performance Battery is useful for evaluating physical frailty, and for a multidimensional evaluation, the Fried frailty phenotype can be used. Specifically for liver transplant candidates, the use of Liver Frailty Index is recommended.

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BACKGROUND: Acute lymphoblastic leukemia (ALL) is a malignant clonal bone marrow disorder with a high mortality rate during the initial therapy. This retrospective study aimed to describe and analyze the risk factors and causes of induction-related mortality (IRM) in an adolescent and adult ALL population treated in a low- and middle-income country. METHODS: From 2009 to 2016, a total of 167 patients were included, of which 50.9% were male with a median age of 28 years. B-immunophenotype represented 97.6%, and high-risk cytogenetics were present in 23.3%. During induction therapy, 91% had at least 1 complication, most of which were infectious, with an IRM of 12%. RESULTS: Factors associated with increased mortality rate were central nervous system (CNS) status [CNS-3: hazard ratio (HR) 3.029; 95% confidence interval (CI), 0.79‒11.49; P =0.103 and CNS-2: HR, 9.98; 95% CI, 2.65‒37.65; P =0.001] and dialysis requirement (HR, 9.15; 95% CI, 2.44‒34.34; P =0.001). CONCLUSION: Our study confirms that ALL patients treated in resource-constrained settings have high rates of IRM, mainly attributed to advanced disease and high tumor burden at diagnosis.

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Resumen Introducción: Ante la crisis epistemológica y sistémica que se encuentra en la civilización occidental, el yagé emerge como alternativa que invita a una reponderación axiológica profunda. Asimismo, el ritual del yagé evidencia los límites del conocimiento médico moderno, dando pauta al abordaje transdisciplinario. Por otro lado, se presentan consecuencias de inserción en el libre mercado, implicando problemas de lucro a costa de tradiciones originarias. En este contexto, se explora el concepto «trabajo espiritual¼ como práctica que busca descolocarse del colonialismo mercantil al tiempo que se aleja del modelo médico moderno. Objetivo: Reflexionar la incorporación del ritual de yagé en Occidente y sus posibilidades como alternativa epistemológica y médica. Materiales y métodos: Revisión de artículos de la base de datos especializados Web of Science, con la palabra clave: "ayahuasca". Resultados: Se estructuró la información teniendo en cuenta los aspectos relacionados con: (a) el contexto de incorporación del yagé al occidente, (b) los límites del conocimiento médico moderno y (c) los problemas de inserción al libre mercado. Conclusiones: Se apoya el diagnóstico de la ruptura epistemológica con occidente, pero reconociendo el estado inicial de las investigaciones y la falta de evidencias documentadas para entrar en una etapa más fructífera para el debate.

Abstract Introduction: In the face of epistemological and systemic crisis in Western civilization, yagé emerges as an alternative that invites a deep axiological reponderation. The yagé ritual demonstrates the limits of modern medical knowledge, giving guidance to a transdisciplinary approach. On the other hand, there are consequences of insertion into the free market, involving profit problems at the expense of original traditions. Thus, the concept of "spiritual work" is explored as a practice that seeks to dislodge itself from commercial colonialism while moving away from the modern medical model. Objective: To reflect on the incorporation of the yage ritual in the West and its possibilities as an epistemological and medical alternative. Materials and methods: Review of articles from the specialized Web of Science database, with the keyword: "ayahuasca". Results: The information was structured considering aspects related to: (a) the context of incorporation of yagé into the West, (b) the limits of modern medical knowledge and (c) the problems of insertion into the free market. Conclusions: The diagnosis of the epistemological rupture with the West is supported while recognizing the initial state of the investigations and the lack of documented evidence in order to enter into a more fruitful debate.

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Introduction  Breast sarcomas are tumors of a mesenchymal origin, with an incidence of less than 1% of the total breast tumors. The diagnosis of this disease is a challenge for pathologists, radiologists, and breast surgeons.  Aim To describe the diagnostic, therapeutic, and outcomes approach of patients with breast sarcoma treated at the National Cancer Institute (NCI) in Bogota, Colombia.  Materials and methods It is a descriptive and retrospective case series study of patients diagnosed with breast sarcoma treated at the NCI during the period between August 1, 2016 and March 30, 2019.  Results  We identified 14 patients diagnosed with breast sarcoma, 10 (71.4%) patients with primary breast sarcomas, and four (28.6%) with sarcomas associated with radiotherapy. The most frequent histological subtype in both, primary and secondary sarcomas, was angiosarcoma (n = 5, 35.7%). 100% (n = 14) of patients received surgical management as primary treatment. Eight (57.1%) patients presented recurrence (disease-free survival (DFS) follow-up of 5.95 months). A total of five deaths were recorded, representing 35.7% of patients (overall survival (OS) follow-up of 23.5 months). Conclusion Breast sarcomas are characterized by aggressive clinical behavior, which is why it is important to make a precise histological diagnosis and thus provide patients with radical surgical procedures that ensure local control of the disease and improve DFS.

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BACKGROUND: The majority of patients with breast cancer in Colombia are admitted into oncological centers at locally advanced stages of the disease (53.9%). The aim of this study was to describe the pathological response obtained with neoadjuvant chemotherapy (NACT) according to the molecular classification of breast cancer in patients with locally advanced tumors treated within the National Cancer Institute (NCI) Functional Breast Cancer Unit (FBCU) in Bogotá, Colombia. MATERIALS AND METHODS: This was an observational, descriptive, historical cohort study of patients with locally advanced breast cancer treated within the NCI FBCU. RESULTS: We included 414 patients who received NACT and surgical management. Most patients had luminal B HER2-negative tumors (n = 134, 32.4%). The overall rate of pathological complete response (pCR) ypT0/ypN0 was 15.2% (n = 63). Tumors that presented the highest rate of pCR were pure HER2, at 40.5% (n = 15; odds ratio [OR], 6.7); however, with a follow-up of 60 months, only the triple negative tumors presented a statistically significant difference for event-free survival (EFS; median recurrence time, 18 months; range, 1-46) and overall survival (OS; median follow-up, 31 months; range 10-57). The molecular subtype that most recurrences presented was luminal B HER2 negative, at 38.3% (n = 28). The majority of recurrences (93.2 %; n = 68; OR, 5.9) occurred in patients in whom no pathological response was obtained (Chevallier 3 and 4). CONCLUSION: Pathological response in locally advanced tumors is related to the molecular subtype of breast cancer, finding higher pCR rates in pure HER2 and triple-negative tumors. A direct relationship was found between disease recurrences and the pathological response, evidencing greater tumor recurrence in patients who did not respond to NACT (Chevallier 3 and 4). EFS and OS were greater in patients with pCR, with statistical significance only in triple-negative tumors. IMPLICATIONS FOR PRACTICE: This research article is of scientific interest, because it describes the clinical and pathological features and analyzes the correlation between pathological response to neoadjuvant chemotherapy and the molecular classification of locally advanced breast cancer in patients treated in the National Cancer Institute in Bogotá, Colombia. It was found that pathological response is related to the molecular subtype of breast cancer. In addition, there is a direct relationship between disease recurrences and pathological response. The survival results were greater in patients with pathological complete response.

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Resumen La neuropatía vasculítica no sistémica es una condición poco común, caracterizada por el compromiso aislado del sistema nervioso periférico a causa de la infiltración celular en el lecho vascular encargado de su irrigación. Es un término acuñado hace poco más de tres décadas y se considera una enfermedad poco descrita y subdiagnósticada. Se presenta el caso clínico de un paciente masculino de mediana edad que debuta con síntomas progresivos de predominio motor en miembros inferiores, quien es sometido a una serie de estudios que permiten concluir el diagnóstico. Es tratado con corticoides sistémicos, agentes citotóxicos y, por último, agentes biológicos con los que se estabilizaron los síntomas.

Summary Non-systemic vasculitic neuropathy is a rare condition characterized by the isolated involvement of the peripheral nervous system caused by cellular infiltration in the vascular bed responsible for its irrigation. It is a term which was coined a little over three decades ago and is considered a poorly described and underdiagnosed disease. Below, we present the clinical case of a middle-aged male patient who began experiencing progressive symptoms of motor predominance in the lower limbs, and who underwent a series of studies in order to conclude a diagnosis. The patient was treated with systemic corticosteroids, cytotoxic agents and, finally, biological agents which stabilized the symptoms.

Resumo A neuropatia vasculítica não sistêmica é uma condição pouco comum, caracterizada pelo compromisso isolado do sistema nervoso periférico a causa da infiltração celular no leito vascular encarregado de sua irrigação. É um termo cunhado há pouco mais de três décadas e se considera uma doença pouco descrita e subdiagnosticada. A seguir, se apresenta o caso clínico de um paciente masculino de meia idade que debuta com sintomas progressivos de predomínio motor em membros inferiores, que é submetido a uma série de estudos que permitem concluir o diagnóstico. É tratado com corticoides sistêmicos, agentes citotóxicos e, por último, agentes biológicos com o que se estabilizaram os sintomas.

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La palabra anquilosis deriva del término griego que significa articulación rígida, asociada a la imposibilidad para la apertura bucal progresiva, consecuencia de la una unión fibrosa, ósea o mixta entre el cóndilo mandibular y la fosa glenoidea. Se presenta como secuela de traumatismos maxilofaciales, infecciones y como manifestación de enfermedades clínicas que cursan con poliartropatías. Esta limitación de la apertura bucal conlleva a: mala higiene oral, caries dental, deformidades dentofaciales y apnea obstructiva del sueño, siendo imperativo el tratamiento quirúrgico, en que la literatura describe múltiples procedimientos a realizar. Nuestro objetivo fue presentar la experiencia quirúrgica de 05 casos seleccionados, que fueron manejados en la institución basándonos en la revisión de protocolos contemporáneos.

The word 'ankylosis' is derived from ancient Greek, meaning 'a rigid joint', in this case associated to an impediment for progressive mouth opening, as a consequence of a fibrous, bony, or mixed tissue junction between the mandibular condyle and the mandibular fossa. This condition may occur as a sequel of mandible and face trauma, infectious diseases, or as a manifestation of chronic diseases leading to joint damage. This limitation in mouth opening may lead to poor oral hygiene, dental cavities, dental and facial deformities, and obstructive sleep apnea. Surgical therapy is mandatory in such cases, and there are many procedures described in the literature. Our objective is to show our surgical experience in 5 selected patients who were operated in our institution on the basis of the current surgical protocols.

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Introducción: La frecuencia de malignidad en presencia de un reporte mamográfico BI-RADS 4A no es conocida en el medio colombiano. Objetivo: Describir la frecuencia de patología maligna en las pacientes que acudieron a la consulta de seno con mamografía BI-RADS 4A en el Hospital de San José, en el periodo 2008-2010. Métodos: Estudio descriptivo de serie de casos. Ingresaron todas las pacientes con reporte de mamografía BI-RADS 4A tomada con intención diagnóstica o de tamizaje de oportunidad que fueron valoradas por los servicios de cirugía general y ginecología. Todas las pacientes fueron llevadas a biopsia. Los casos positivos siguieron el protocolo del manejo del servicio. Resultados: Se identificaron 51 casos con mamografía BI-RADS 4A, de las cuales completaron el estudio para diagnóstico 49 pacientes. La edad media fue 54,2 años (DE: 9,2). Se indicaron para tamizaje 22 mamografías (44,9) y hubo 27 con intención diagnóstica (55,1). Seis pacientes presentaron patología maligna (12,2): tres casos con carcinoma ductal infiltrante, dos con carcinoma ductal in situ y una con carcinoma tubular. En la población con hallazgos benignos, cuatro presentaron hiperplasia sin atipias. Conclusiones: Ante el hallazgo mamográfico BI-RADS 4A, se deben continuar esfuerzos en la búsqueda de malignidad.

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Estudio descriptivo de corte transversal para determinar la prevalencia de patología maligna en mujeres mayores de 14 años que consultaron por masa sólida palpable en mama al servicio de cirugía general del Hospital de San José, de Bogotá D.C. durante el período marzo 2009 a febrero de 2010. Esta prevalencia fue de 18,1%. El promedio de edad fue 60.1 años, el de la menopausia 50 años, la edad del primer parto 25.8 años y el promedio de hijos 1.7. El tiempo de lactancia materna fue 10.5 meses, no había antecedentes personales de cáncer de mama y sólo 13,3% presentaron antecedente familiar de esta malignidad. El 78,3% (65) de las masas sólidas palpables fueron detectadas por autoexamen de seno. El tiempo de aparición fue en promedio de 14.1 meses (DE: 17 meses) y como manifestación clínica asociada se reportó dolor en la mayoría. La clasificación de BIRADS predominante para ecografía y mamografía en mujeres con patología maligna fue el tipo 4. Entre los diagnósticos por biopsia predominó el carcinoma ductal infiltrante (80%) y en patología benigna el fibroadenoma (56%). El tratamiento más frecuente fue quirúrgico.

This is a descriptive cross sectional study conducted to determine the prevalence of breast malignant pathology in women more than 14 years old who consulted for a palpable solid mass in the breast to the General Surgery Department at Hospital de San José, Bogotá DC. between March 2009 and February 2010. The prevalence rate was 18.1%. Mean age was 60.1 years. Average age at onset of menopause was 50 years, age at first birth 25.8 years and number of children 1.7. Average period of time they breast fed their children was 10.5 months. There were no personal antecedents of breast cancer, and family history of this malignancy was found in 13.3% only. Sixty-five (78.3%) of the palpable solid masses were detected by self-exam. The mean time of appearance was 14.1 months (SD: 17 months) and the majority of patients reported pain as associated clinical manifestation. The predominant BIRADS classification for ultrasound and mammography in women with malignancy was type 4. The predominant result in biopsies was, infiltrating ductal carcinoma (80%), and fibroadenoma (56%), a benign condition. Surgery was the most frequently used therapeutic intervention.

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