RESUMO
PURPOSE: Radiotherapy (RT) causes an inflammatory reaction of the tissue which leads to fibrosis and reduced functioning of the pelvic organs. Few studies have shown significant relationships between side effects and RT in uterine tumors. Here, the urological, lymphedema, pelvic pain and gastrointestinal (GI) symptoms were studied before and after RT in patients with primary uterine tumors using the EORTC QLQ-EN24, specifically designed for uterine cancer patients. METHODS: This prospective cohort study comprised patients with primary uterine tumors who received pelvic radiotherapy (RT). A total of 43 patients were included from May 2014 to February 2019. Patients completed the questionnaires for global health status and functioning before the start of RT and at 3 and 12 months after RT. RESULTS: We found a significant worsening of the urological symptoms 3 months after RT which persisted up to 12 months after RT compared to baseline values prior to start of RT (p = 0.007). An exacerbation of the urinary symptoms was seen in patients with vaginal brachytherapy/boost compared to patients with pelvic RT at 12 months after RT (p = 0.053). The severity of lymphedema symptoms increased from RT start to 12 months after RT (p = 0.019) and the pelvic pain were higher at 3 months after RT compared to before RT (p = 0.004). Also, the level of GI symptoms was significantly higher 12 months after RT compared to the RT start (p < 0.001). CONCLUSIONS: The urologic, lymphedema, pelvic pain and GI symptoms all increase after RT.
Assuntos
Diarreia/etiologia , Linfedema/etiologia , Dor Pélvica/etiologia , Transtornos Urinários/etiologia , Neoplasias Uterinas/radioterapia , Adulto , Idoso , Braquiterapia/efeitos adversos , Braquiterapia/métodos , Fracionamento da Dose de Radiação , Feminino , Inquéritos Epidemiológicos , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , Estudos Prospectivos , Qualidade de Vida , Radioterapia/efeitos adversos , Reirradiação/efeitos adversos , Suécia , Avaliação de Sintomas , Neoplasias Uterinas/complicações , Neoplasias Uterinas/patologiaRESUMO
School children are regularly tested in Sweden at age 7, 10 and 13. We report the audiometric results of 2264 school children tested at these three ages. Audiometry was performed as hearing screening at 0.5, 1, 2, 4, 6, 8 kHz with a screening level of 20 dBHL. Unilateral hearing losses with one test frequency affected were most common and bilateral hearing losses were least common. The hearing loss was more common in boys than in girls at all ages. Hearing loss at 2 kHz in boys at age 7 were uncharged in most cases (13/17 boys still failing screening at age 13). High frequency losses were most common, particularly at age 10 and 13 and more prevalent in boys than in girls, suggesting early noise induced hearing loss as an etiology.