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Abstract Preeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coagulation cascade activation. Recently, the role of the complement system has been considered. This syndrome is one of the main causes of maternal and fetal mortality and morbidity. This article discusses the hypothesis of preeclampsia being triggered by the occurrence of inadequate implantation of the syncytiotrophoblast, associated with bleeding during the first stage of pregnancy and with augmented thrombin generation. Thrombin activates platelets, increasing the release of antiangiogenic factors and activating the complement system, inducing the membrane attack complex (C5b9). Immature platelet fraction and thrombin generation may be possible blood biomarkers to help the early diagnosis of preeclampsia.

Resumo A pré-eclâmpsia, uma síndrome da gestação humana, é caracterizada por elevação da pressão arterial e proteinúria patológica após a 20ª semana de gestação. Sua etiologia permanece desconhecida, e seus mecanismos fisiopatológicos estão relacionados à hipoperfusão placentária, disfunção endotelial, inflamação, e ativação da cascata de coagulação. Recentemente, o papel do sistema do complemento foi considerado. Essa síndrome é uma das principais causas de morbidade e mortalidade materna e fetal. Este artigo discute a hipótese de a pré-eclâmpsia ser desencadeada pela ocorrência da implantação inadequada do sinciciotrofoblasto, associada ao sangramento durante o primeiro trimestre da gravidez com aumento da geração de trombina. A trombina ativa plaquetas, aumentando a liberação de fatores antiangiogênicos na circulação e ativando o sistema do complemento, especialmente o complexo de ataque de membrana (C5b9). Portanto, a fração de plaquetas imaturas e a geração de trombina podem ser possíveis biomarcadores sanguíneos para auxílio no diagnóstico precoce da pré-eclâmpsia.

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Preeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coagulation cascade activation. Recently, the role of the complement system has been considered. This syndrome is one of the main causes of maternal and fetal mortality and morbidity. This article discusses the hypothesis of preeclampsia being triggered by the occurrence of inadequate implantation of the syncytiotrophoblast, associated with bleeding during the first stage of pregnancy and with augmented thrombin generation. Thrombin activates platelets, increasing the release of antiangiogenic factors and activating the complement system, inducing the membrane attack complex (C5b9). Immature platelet fraction and thrombin generation may be possible blood biomarkers to help the early diagnosis of preeclampsia.

A pré-eclâmpsia, uma síndrome da gestação humana, é caracterizada por elevação da pressão arterial e proteinúria patológica após a 20ª semana de gestação. Sua etiologia permanece desconhecida, e seus mecanismos fisiopatológicos estão relacionados à hipoperfusão placentária, disfunção endotelial, inflamação, e ativação da cascata de coagulação. Recentemente, o papel do sistema do complemento foi considerado. Essa síndrome é uma das principais causas de morbidade e mortalidade materna e fetal. Este artigo discute a hipótese de a pré-eclâmpsia ser desencadeada pela ocorrência da implantação inadequada do sinciciotrofoblasto, associada ao sangramento durante o primeiro trimestre da gravidez com aumento da geração de trombina. A trombina ativa plaquetas, aumentando a liberação de fatores antiangiogênicos na circulação e ativando o sistema do complemento, especialmente o complexo de ataque de membrana (C5b9). Portanto, a fração de plaquetas imaturas e a geração de trombina podem ser possíveis biomarcadores sanguíneos para auxílio no diagnóstico precoce da pré-eclâmpsia.

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BACKGROUND: Pressure injuries (PIs), especially in the sacral region are frequent, costly, and increase morbidity and mortality of patients in an intensive care unit (ICU). These injuries can occur as a result of prolonged pressure and/or shear forces. Neuromuscular electrical stimulation (NMES) can increase muscle mass and improve local circulation, potentially reducing the incidence of PI. METHODS: We performed a randomized controlled trial to assess the efficacy and safety of NMES in preventing PI in critically ill patients. We included patients with a period of less than 48 h in the ICU, aged ≥ 18 years. Participants were randomly selected (1:1 ratio) to receive NMES and usual care (NMES group) or only usual care (control group-CG) until discharge, death, or onset of a PI. To assess the effectiveness of NMES, we calculated the relative risk (RR) and number needed to treat (NNT). We assessed the muscle thickness of the gluteus maximus by ultrasonography. To assess safety, we analyzed the effects of NMES on vital signs and checked for the presence of skin burns in the stimulated areas. Clinical outcomes were assessed by time on mechanical ventilation, ICU mortality rate, and length of stay in the ICU. RESULTS: We enrolled 149 participants, 76 in the NMES group. PIs were present in 26 (35.6%) patients in the CG and 4 (5.3%) in the NMES group (p ˂ 0.001). The NMES group had an RR = 0.15 (95% CI 0.05-0.40) to develop a PI, NNT = 3.3 (95% CI 2.3-5.9). Moreover, the NMES group presented a shorter length of stay in the ICU: Δ = - 1.8 ± 1.2 days, p = 0.04. There was no significant difference in gluteus maximus thickness between groups (CG: Δ = - 0.37 ± 1.2 cm vs. NMES group: Δ = 0 ± 0.98 cm, p = 0.33). NMES did not promote deleterious changes in vital signs and we did not detect skin burns. CONCLUSIONS: NMES is an effective and safe therapy for the prevention of PI in critically ill patients and may reduce length of stay in the ICU. Trial registration RBR-8nt9m4. Registered prospectively on July 20th, 2018, https://ensaiosclinicos.gov.br/rg/RBR-8nt9m4.

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BACKGROUND: The increasing global use of smartphones has contributed to the growing use of apps for various health conditions, showing promising results. Through mobile apps, it is possible to perform chronological and iconographic follow-up of wounds, such as pressure ulcers, using a simple and practical tool. However, numerous surveys have pointed out issues related to the functionality, design, safety, and veracity of app information. OBJECTIVE: The objective of this study was to perform a systematic review of published studies regarding mobile apps and a systematic survey in app stores looking for apps developed to identify, evaluate, treat, and/or prevent pressure ulcers in adults, and to evaluate those apps based on software quality characteristics. METHODS: This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The main bibliographic databases were searched between January 1, 2007 and October 15, 2018, and an app survey was performed in app stores. The selected studies were evaluated according to software quality characteristics by the International Organization for Standardization/International Electrotechnical Commission (ie, ISO/IEC 25010:2011) that involve functionality, efficiency, compatibility, usability, reliability, safety, maintenance, and portability. RESULTS: The search in databases and web-based app stores returned a total of 2075 studies. After removal of duplicates and screening of titles and abstracts, 48 complete articles were evaluated for eligibility, and among these, six were included for qualitative synthesis. CONCLUSIONS: In this review, it was observed that all studies involved the initial phase of app development or improvement, and therefore, the apps still need to be evaluated using different software quality characteristics, so that in the future, a gold standard can be approached. Therefore, the prescription of an app for the identification, evaluation, treatment, and/or prevention of pressure ulcers in adults is currently limited. However, the evaluated studies provided important insights for future research. It is of utmost importance that future surveys develop apps jointly with users, using collaborative and cocreative processes and assess patients in real-world situations across different service settings, and they should consider different ethnicities, so that apps are useful to end users, such as patients, family members, health professionals, and students, in the health area. In addition, it is necessary for studies to describe the methodological course of app development in a clear and objective way in order to ensure reproducibility of the study and to offer inputs to allow future research to approach the development of ideal apps that are geared to positively impact the health of end users. TRIAL REGISTRATION: PROSPERO CRD42018114137; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=114137.

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A incontinência urinária é definida como qualquer perda urinária involuntária e constitui um problema social e higiênico. O objetivo do estudo foi analisar a eficácia de tratamento fisioterapêutico na reeducação da musculatura do assoalho pélvico de mulheres com incontinência urinária por meio da cinesioterapia versus eletroestimulação. Trata-se de estudo quase experimental realizado na clínica FisioUNISC entre outubro de 2007 e maio de 2008. O estudo avaliou a força de contração da musculatura perineal em 36 mulheres por intermédio do perineômetro digital, do teste do absorvente e do questionário de qualidade de vida - King's Health Questionnaire (KHQ). A terapêutica foi constituída de dois grupos distintos: o primeiro realizava a cinesioterapia; o segundo, a eletroestimulação. Cada grupo concretizou 20 sessões de tratamento, realizado três vezes por semana. Mediante o teste do absorvente, constatou-se a redução na perda de urina e o consecutivo progresso da força de contração vaginal nos dois grupos investigados, com a cinesioterapia exprimindo melhor resultado. O KHQ evidenciou resultados similares, com melhora na pontuação para os dois grupos, destacando maior pontuação no grupo da cinesioterapia. Os resultados mostraram melhora do quadro de incontinência urinária com os dois tratamentos, contudo a cinesioterapia se mostrou a opção mais efetiva. [AU]

Urinary incontinence is defined as any involuntary urinary loss and is a social and hygienic problem. The objective of this study was to analyze the effectiveness of physiotherapeutic treatment in reeducating the pelvic floor musculature of women with urinary incontinence through kinesiotherapy versus electrostimulation. It is a quasi-experimental study conducted at the FisioUNISC clinic between October 2007 and May 2008. The study assessed the strength of perineal musculature contraction in 36 women, using digital perineometer, pad test and the King's Health Questionnaire (KHQ). Therapy was applied to two distinct groups: the first one was subjected to kinesiotherapy while the second one to electrostimulation. Each group completed 20 treatment sessions three times a week. Reduced urine loss and subsequent progression of vaginal contraction strength in the two investigated groups were observed by means of the pad test, with kinesiotherapy expressing better results. The KHQ showed similar results, with improved scores for both groups and higher scores in the kinesiotherapy group. The results showed improvement in urinary incontinence with both treatments; however, kinesiotherapy was the most effective option. [AU]

La incontinencia urinaria es definida como cualquier pérdida urinaria involuntaria y constituye un problema social e higiénico. El objetivo del estudio fue analizar la eficacia del tratamiento fisioterapéutico en la reeducación de la musculatura del suelo pélvico de mujeres con incontinencia urinaria por medio de la cinesiterapia versus electroestimulación. Se trata de un estudio casi experimental realizado en la clínica FisioUNISC entre octubre de 2007 y mayo de 2008. El estudio evaluó la fuerza de contracción de la musculatura perineal en 36 mujeres por intermedio del perineómetro digital, del test de la compresa y del cuestionario de calidad de vida - King's Health Questionnaire (KHQ). La terapéutica fue constituida por dos grupos distintos: el primero realizaba la cinesiterapia; el segundo, la electroestimulación. Cada grupo llevó a cabo 20 sesiones de tratamiento, realizado tres veces por semana. Mediante el test de la compresa, se constató la reducción en la pérdida de orina y el consecutivo progreso de la fuerza de contracción vaginal en los dos grupos investigados, manifestando con la cinesiterapia mejor resultado. El KHQ evidenció resultados semejantes, con la mejora en la puntuación para los dos grupos, destacando mayor puntuación en el grupo de la cinesiterapia. Los resultados mostraron mejora del cuadro de incontinencia urinaria con los dos tratamientos, no obstante la cinesiterapia se mostró la opción más efectiva. [AU]

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Introdução: As úlceras por pressão são áreas localizadas de morte celular que se desenvolvem quando o tecido mole é comprimido entre uma proeminência óssea e uma superfície dura por um período de tempo prolongado. As úlceras são de difícil cicatrização, sendo responsáveis por um alto índice de orbidade. A laserterapia de baixa intensidade vem sendo empregada como um recurso fisioterápico capaz de apresentar resposta efetiva na cicatrização de tecidos. Objetivos: Comparar a ação dos lasers Hélio-Neônio e Arseneto de Gálio no processo cicatricial de úlceras por pressão e desenvolver um trabalho com medidas de prevenção como tratamento. Métodos: Foram tratados um usuário com o laser Hélio-Neônio e dois com o laser Arseneto de Gálio, selecionados aleatoriamente, além de ter sido realizado um trabalho preventivo com esses sujeitos. Resultados: Os dois tipos de laser demonstraram resultados eficazes na cicatrização dos processos ulcerativos. Conclusão: Usuários que, juntamente com a laserterapia, seguiram corretamente as medidas preventivas obtiveram melhores resultados do que aqueles que não seguiram corretamente as orientações. (AU)

Introduction: The pressure ulcers are located areas of cellular tissue death, that develop themselves when the soft tissue is compressed, between a bone proeminence and a hard surface, for a long period of time. The ulcers are of hard scarring and, responsible by a high index of morbidity, generating a difficult handling situation and high economic costs for the health agencies. In this context appears the low intensity laser therapy that is being used as afhysiotherapic resource capable to present effective reply in the tissue scarring. Objectives: To compare the action of HeNe and AsGa laser in the scarring process of pressure ulcers, as well as evaluating the effect of prevention measures in the treatment. Methods: There had been treated four users on the HeNe laser and two users on the AsGa laser, aleatory chosen, and also had been done a prevention work with the users. Results: Both types of laser had demonstrated positive results in the healing of these ulcerative processes. Conclusion: The users who, with the laser therapy, had also followed prevention measures correctly, they had gotten better results than those who had not followed the orientations correctly. (AU)

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Objective: to compare the scores of knowledge in teams participating or not participating in educational interventions about pressure ulcers. Method: a quantitative study with experimental design. Data were collected through a validated questionnaire. The study included 71 individuals, including nurses and nursing technicians from three intensive care units, divided into intervention group and control group. Data analysis considered the scores of the groups in the moment before and after intervention. To check the average rate of correct answers, we calculated the mean and standard deviation. We carried out the Mann-Whitney test for analysis of two independent samples, and the Wilcoxon test for related samples. Results: The mean percentage of correct answers, at the baseline was 74.1% (SD = 26.4) in the intervention group and 76.0% (SD = 22.9) in the control group and post time -intervention, was 87.8% (SD = 18.8) in the group receiving educational intervention, considering that in the control group it was 79.1% (SD = 22.2). The group that participated in educational interventions did not reach the proper average of 90% correct answers for the test. Conclusion: educational interventions on staging, evaluation and prevention of pressure ulcers contributed significantly to the increase of correct responses score in the knowledge test of the intervention group and improved their knowledge on the subject.

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ABSTRACT Objective: to compare the scores of knowledge in teams participating or not participating in educational interventions about pressure ulcers. Method: a quantitative study with experimental design. Data were collected through a validated questionnaire. The study included 71 individuals, including nurses and nursing technicians from three intensive care units, divided into intervention group and control group. Data analysis considered the scores of the groups in the moment before and after intervention. To check the average rate of correct answers, we calculated the mean and standard deviation. We carried out the Mann-Whitney test for analysis of two independent samples, and the Wilcoxon test for related samples. Results: The mean percentage of correct answers, at the baseline was 74.1% (SD = 26.4) in the intervention group and 76.0% (SD = 22.9) in the control group and post time -intervention, was 87.8% (SD = 18.8) in the group receiving educational intervention, considering that in the control group it was 79.1% (SD = 22.2). The group that participated in educational interventions did not reach the proper average of 90% correct answers for the test. Conclusion: educational interventions on staging, evaluation and prevention of pressure ulcers contributed significantly to the increase of correct responses score in the knowledge test of the intervention group and improved their knowledge on the subject.

resumo Objetivo: comparar os escores de conhecimento sobre úlcera por pressão das equipes que participaram ou não de intervenções educativas. Método: estudo quantitativo com delineamento experimental. Os dados foram coletados por meio de questionário validado. Participaram deste estudo 71 pessoas, dentre enfermeiros e técnicos de Enfermagem de três unidades de terapia intensiva, divididos em grupo-intervenção e grupo-controle. A análise dos dados considerou os escores dos grupos no momento pré e pós-intervenção. Para verificar o escore médio de acertos, foram calculados a média e o desvio-padrão. Foi realizado o Teste de Mann-Whitney, para análise de duas amostras independentes, e o Teste de Wilcoxon, para amostras relacionadas. Resultados: a porcentagem média de acertos, no momento inicial, foi de 74,1% (dp=26,4) no grupo-intervenção e 76,0% (dp=22,9) no grupo-controle e, no momento pós-intervenção, foi de 87,8% (dp=18,8) no grupo que recebeu intervenção educativa, considerando-se que no grupo-controle foi de 79,1% (dp=22,2). O grupo que participou de intervenções educativas não atingiu a média adequada de 90% de acertos para o teste. Conclusão: as intervenções educativas sobre estadiamento, avaliação e prevenção da úlcera por pressão contribuíram significativamente para o aumento do escore de acertos no teste de conhecimento do grupo-intervenção e melhoraram o conhecimento sobre o tema.

RESUMEN Objetivo: comparar las puntuaciones de los conocimientos acerca de las úlceras por presión de los equipos que han participado o no de intervenciones educativas. Método: estudio cuantitativo con diseño experimental. Los datos fueron recolectados a través de cuestionario validado. En el estudio participaron 71 personas, incluyendo enfermeras y técnicos de enfermeria de tres unidades de cuidados intensivos, divididos en grupo de intervención y grupo control. El análisis de los datos consideró las puntuaciones de los grupos antes y después de la intervención. Para comprobar la tasa media de respuestas correctas, se calculó la media y el desvio estándar (DE). La prueba de Mann-Whitney fue realizada para el análisis de dos muestras independientes y la prueba de Wilcoxon para muestras relacionadas. Resultados: la media del porcentaje de respuestas correctas, al inicio del estudio fue de 74,1% (DE = 26,4) en el grupo de intervención y 76,0% (DE = 22,9) en el grupo de control y en el tiempo post-intervención, fue del 87,8% (DE = 18,8) en el grupo que recibió la intervención educativa, teniendo en cuenta que en el grupo control fue de 79,1% (DE = 22,2). El grupo que participó en las intervenciones educativas no llegó a la media apropiada de 90% de respuestas correctas de la prueba. Conclusión: las intervenciones educativas en la estadificación, evaluación y prevención de las úlceras por presión contribuyeron significativamente al aumento de puntuación de aciertos en la prueba de conocimiento en el grupo de intervención y mejoraron su conocimiento sobre el tema.

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