RESUMO
Synoviorthesis is already widely used in the treatment of chronic haemophilic synovitis. The aim of this study was evaluate the effectiveness of oxytetracicline synoviorthesis on the frequency of haemarthrosis in haemophilic children with chronic synovitis and its impact on joint function. Between January 2001 and October 2006, we performed 34 synoviorthesis in 28 paediatric patients (6-16 years old) with diagnosis of haemophilic arthropathy stage I-II. At each joint were administered five doses of oxytetracycline for five consecutive weeks at doses of 100 mg in elbow and ankle and 250 mg in the knee. The frequency of haemarthrosis and range of joint mobility were evaluated before and after of treatment. The results were analysed with Student t-test and descriptive statistics. Thirty-four joints were treated, including 20 knees (58.8%), eight elbows (23.5%) and six ankles (17.6%). Median follow-up was 46.3 months (range 12-71 months). The frequency of haemarthrosis was recorded before treatment 47.3 year(-1) (range 12-96, P < 0.0001) and decreased to 3.5 year(-1) (range 0-15, P = 0.0119) after treatment. The range of joint motion in flexion-extension before treatment was 84.9°, while after this was 97.5° (P = 0.0119). The synoviorthesis with oxytetracycline has shown a favourable effect in the treatment of chronic haemophilic synovitis in reducing the frequency of haemarthrosis and improvement was observed consistently in the range of motion.
Assuntos
Antibacterianos/uso terapêutico , Hemartrose/tratamento farmacológico , Hemofilia A/complicações , Oxitetraciclina/uso terapêutico , Sinovite/tratamento farmacológico , Adolescente , Adulto , Articulação do Tornozelo , Criança , Doença Crônica , Articulação do Cotovelo , Seguimentos , Hemartrose/etiologia , Humanos , Injeções Intra-Articulares , Articulação do Joelho , Amplitude de Movimento Articular/efeitos dos fármacos , Sinovite/etiologia , Adulto JovemRESUMO
Peripheral pancytopenia is a syndrome which allows for an early diagnosis, and although is may cover a large number of pathological entities, it can be clearly defined into three groups of illnesses which evolve with this syndromal manifestations. The first group includes non-neoplastic illnesses which include aplastic anemia, hemophagocytic syndrome associated to infection, immunological diseases and the deficiency of folates or vitamin B12. The second group includes neoplastic diseases as acute leukemia, non-Hodgkin lymphoma, and Hodgkin's lymphoma with myelofibrosis, malignant histiocytosis and non-hematological neoplasms, like the neuroblastoma and the embryonal rhabdomyosarcoma. The third group is formed by illnesses which have some similarity with neoplasms.
Assuntos
Pancitopenia/etiologia , Anemia Aplástica/complicações , Deficiência de Ácido Fólico/complicações , Histiocitose/complicações , Humanos , Neoplasias/complicações , Defeitos do Tubo Neural/complicações , Pancitopenia/diagnóstico , Pancitopenia/imunologia , Deficiência de Vitamina B 12/complicaçõesRESUMO
Se informa del hallazgo en una familia mexicana de tres hermanos dobles heterocigotos para la hemoglobina E y la talasemia beta que padecen anemia hemolitica. Son originarios del centro del pais y no tienen ancestros asiaticos, africanos ni mediterraneos. Se estudiaron tres generaciones de la familia identificando varios heterocigotos para la hemoglobina E y la talasemia beta. La hemoglobina E no habia sido encontrada antes en Mexico y asociada a talasemia beta no tiene antecedentes en America Latina