RESUMO

Several small molecules have the capacity to cleave DNA promptly at high yields, even under mild conditions. Usually, this activity has no constraints, occurring without external or user control. Here, we demonstrate that UV-light exposure can greatly enhance the DNA cleavage activity promoted by four ternary copper(ii) complexes. A remarkable photocontrolled activity was achieved, which may be interesting for chemical and biochemical applications.

Assuntos

Cobre/farmacologia , Compostos Heterocíclicos/farmacologia , Compostos Organometálicos/farmacologia , Cobre/química , Clivagem do DNA , Relação Dose-Resposta a Droga , Compostos Heterocíclicos/química , Humanos , Estrutura Molecular , Compostos Organometálicos/química , Raios Ultravioleta