RESUMO

Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.

Assuntos

Neuropilinas/metabolismo , Semaforinas/metabolismo , Timo/citologia , Timo/metabolismo , Animais , Movimento Celular , Humanos , Sistema Nervoso/metabolismo , Linfócitos T/citologia , Linfócitos T/metabolismo , Timo/patologia