RESUMO
BACKGROUND: Benign essential blepharospasm (BEB) is the most common adult-onset focal facial dystonia and its treatment of choice is periodic application of botulinum toxin (BtA). It has a higher incidence in middle and late adulthood, especially in women between 40 and 60 years of age. OBJECTIVE: To carry out the translation and cross-cultural adaptation of the CDQ24 questionnaire in its Spanish version in patients diagnosed with BEB who have been treated with BtA in an ophthalmologic center in Bogotá - Colombia. MATERIALS AND METHODS: Pilot test of validation study and adaptation of a scale assembled in a prospective cohort of the CDQ24 instrument to Spanish in adult patients with primary blepharospasm treated with botulinum toxin in Bogota, Colombia. RESULTS: We obtained a sample of 26 patients to whom the instrument was applied after translation and retranslation of the original document, composed of 19 (73%) women with a median age of 64.5 years; the average time to answer the survey was 4.93â¯min. The internal consistency of the scale evaluated by Cronbach's Alpha had a total score of 0.78. Criterion validity between the CDQ24 scale and the WHOQOL-BREF quality of life scale was determined by determining correlation between the Emotional Well-Being and Phsychological domains of both scales. CONCLUSIONS: The translation and cross-cultural adaptation of the CDQ-24 scale into Spanish allowed the applicability of the instrument to the Spanish-speaking population during the pilot test, which allows us to continue the relevant studies in the study population.
Assuntos
Blefarospasmo , Comparação Transcultural , Traduções , Humanos , Blefarospasmo/tratamento farmacológico , Feminino , Pessoa de Meia-Idade , Projetos Piloto , Masculino , Idoso , Adulto , Estudos Prospectivos , Colômbia , Qualidade de Vida , Inquéritos e Questionários , Toxinas Botulínicas/uso terapêutico , Fármacos Neuromusculares/uso terapêutico , Reprodutibilidade dos Testes , Toxinas Botulínicas Tipo A/uso terapêuticoRESUMO
Silver nanoparticles (AgNPs) have aroused great interest for applications as fungicides in agriculture. This study reports the synthesis of AgNPs by green chemistry using silver nitrate (AgNO3) as the precursor agent and a coriander leaf extract as the reducing agent and surfactant. The evaluation of their antifungal properties was carried out when placed in contact with Fusarium solani and Rhizopus stolonifer phytopathogens. The extract and AgNP characterizations were performed using UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), dynamic light scattering (DLS) and scanning electron microscopy (SEM). The evaluation of antifungal properties was carried out by exposing the phytopathogens to different concentrations of AgNPs in PDA (Potato Dextrose Agar). It was found that it was possible to identify the presence of flavones and flavonoids in the extract, compounds that were also involved in the synthesis process of AgNPs. In addition, the UV-Vis analysis of the obtained AgNPs by green chemistry showed resonance peaks at around 428 nm. Furthermore, a high distribution of AgNP sizes, with high concentrations of below 100 nm, was identified, according to DLS measurements. Using SEM images, the information provided by DLS was confirmed, and a crystallite size of 29.24 nm was determined with the help of XRD measurements. Finally, when exposing the phytopathogens to the action of AgNPs, it was concluded that, at a concentration of 1 mg/mL AgNPs, their growth was totally inhibited.
Assuntos
Psoríase , Colômbia/epidemiologia , Humanos , Prevalência , Psoríase/epidemiologia , Sistema de RegistrosRESUMO
Unilateral Transtibial Amputees (UTA) usually present deficiencies in the mechanisms underlying their gait likely because of the absence of the resected segment, thus having an impact on the ability to actively adjust the lower limb prosthesis. Five participants with UTA were evaluated considering the ground reaction forces during gait by using an integrated BTS GAITLAB system. The first and the second vertical peak forces tended to be greater in the Healthy Lower Limb (HLL) than in the Lower Limb prosthesis (LLP). Both the deceleration and propulsion forces were lower in this limb prosthesis, in addition, a variability of the mediolateral force was observed. Maintaining active control of the center of gravity during gait from the HLL was probably due to mechanical restrictions to actively control the ankle and the limitations for force absorption and generation that allow controlling postural stability during gait from the LLP.
Assuntos
Amputados , Membros Artificiais , Amputação Cirúrgica , Fenômenos Biomecânicos , Marcha , HumanosRESUMO
Stable isotope ratios of C and N in the bone tissue of three different skeletal elements (angular, cleithrum and vertebra) of three fish species from different evolutionary lineages (Clupeiformes, Atheriniformes and Notothenioidei) were determined before (δ13 Cbulk and δ15 Nbulk ) and after demineralization and delipidation (δ13 Cdml and δ15 Ndml ). One of the species had cellular bone and the other two had acellular bone. Results revealed that δ15 N and δ13 C values from different skeletal elements were interchangeable in species with acellular bone, but caution was needed in species with cellular bone, as δ15 N values varied among skeletal elements. Furthermore, δ15 Nbulk values were significantly lower than δ15 Ndml values in the three species, thus suggesting that they are not comparable. This difference is probably because δ15 Nbulk refers to total bone protein and δ15 Ndml to collagen only.
Assuntos
Osso e Ossos/química , Peixes , Animais , Técnica de Desmineralização Óssea , Isótopos de Carbono/análise , Lipídeos/isolamento & purificação , Isótopos de Nitrogênio/análise , Perciformes , Alimentos MarinhosRESUMO
OBJETIVO: determinar la frecuencia, características clínicas e histopatológicas y hallazgos radiológicos asociados a alto grado de malignidad, en los tumores óseos diagnosticados en el Departamento de Patología del Hospital Escuela de Tegucigalpa. MATERIALES Y METODOS: estudio prospectivo, descriptivo, desde junio del 2002 hasta junio del 2005. Se evaluaron 143 casos de biopsias con sospecha de neoplasia ósea. Cada biopsia se examinó con el respectivo estudio radiológico. RESULTADOS: 37% (n=53)fueron tumores malignos primarios, 54.5% (n=78),tumores benignos; 8.3%(n=12) tumores metastásicos. El tumor maligno más frecuente fue el osteosarcoma convencional (45.2%), localizado en la región de la rodilla(80%), predominando entre los 16 y los 30 años de edad. De los tumores benignos, 37 (47.4 %) fueron osteocondromas. De los tumores metastáticos el 58.3% fueron carcinomas (adenocarcinoma y carcinoma de sitio no especificado). Los hallazgos radiológicos más relevantes en los tumores malignos fueron: el patrón apolillado, infiltrativo y geográfico de márgenes indefinidos, con zona de transición corta, y afección apartes blandas. Se encontró una buena concordancia clínica- radiológica. CONCLUSIONES: La frecuencia y características clínicas e histopatológicas de los tumores óseos evaluados en el Departamento de Patología del Hospital Escuela no difieren significativamente de los reportados en la literatura mundial. La presencia radiológica de patrón apolillado, infiltrativo, o geográfico de bordes indefinidos, reacción perióstica, con una zona de transición amplia y afectación de partes blandas debe hacer sospechar la presencia de un tumor óseo maligno...(AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Ósseas/diagnóstico , Osteossarcoma/diagnóstico , Osteossarcoma/patologia , Diagnóstico Clínico/diagnóstico , Radiologia/métodos , Biópsia/métodos , Carcinoma/diagnóstico , PatologiaRESUMO
OBJETIVO: determinar la frecuencia, características clínicas e histopatológicas y hallazgos radiológicos asociados a alto grado de malignidad, en los tumores óseos diagnosticados en el Departamento de Patología del Hospital Escuela de Tegucigalpa. MATERIALES Y METODOS: estudio prospectivo, descriptivo, desde junio del 2002 hasta junio del 2005. Se evaluaron 143 casos de biopsias con sospecha de neoplasia ósea. Cada biopsia se examinó con el respectivo estudio radiológico. RESULTADOS: 37% (n=53)fueron tumores malignos primarios, 54.5% (n=78),tumores benignos; 8.3%(n=12) tumores metastásicos. El tumor maligno más frecuente fue el osteosarcoma convencional (45.2%), localizado en la región de la rodilla(80%), predominando entre los 16 y los 30 años de edad. De los tumores benignos, 37 (47.4 %) fueron osteocondromas. De los tumores metastáticos el 58.3% fueron carcinomas (adenocarcinoma y carcinoma de sitio no especificado). Los hallazgos radiológicos más relevantes en los tumores malignos fueron: el patrón apolillado, infiltrativo y geográfico de márgenes indefinidos, con zona de transición corta, y afección apartes blandas. Se encontró una buena concordancia clínica- radiológica. CONCLUSIONES: La frecuencia y características clínicas e histopatológicas de los tumores óseos evaluados en el Departamento de Patología del Hospital Escuela no difieren significativamente de los reportados en la literatura mundial. La presencia radiológica de patrón apolillado, infiltrativo, o geográfico de bordes indefinidos, reacción perióstica, con una zona de transición amplia y afectación de partes blandas debe hacer sospechar la presencia de un tumor óseo maligno...
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Osteossarcoma , Diagnóstico Clínico/diagnóstico , Neoplasias Ósseas/diagnóstico , Biópsia/métodos , Carcinoma/diagnóstico , Patologia , Radiologia/métodosRESUMO
The investigation of an Argentine collection of Enydra anagallis afforded sesquiterpene lactones of the melampolide type two of which were previously known. Their structures were elucidated by spectroscopic methods.