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BACKGROUND: Cerebral aneurysms, especially large and giant aneurysms, pose challenges in neurointerventional surgery. Treatment choices involve clinical presentation, aneurysm details, and global resource variations. Neurointerventional methods, while innovative, may be cost restrictive in certain regions. In public healthcare, cost is crucial, notably in countries like Brazil. This study examines the device specific cost estimation of flow diverters (FD) and traditional stent assisted coiling (SAC) for large and giant cerebral aneurysms, providing insights into optimizing neurosurgical interventions within the Brazilian public health system's unique challenges. METHODS: A comprehensive retrospective analysis was conducted at our medical center of cases of large and giant aneurysms treated between 2013 and 2023. Determination of the estimated number of coils for aneurysms previously treated with FDs at our center was made, with the cost of each case, and the difference between both treatments was calculated. RESULTS: We investigated the profiles of 77 patients: 40 had large aneurysms (51.9%) and 37 had giant aneurysms (48.1%). Large aneurysms had a mean cost difference of US$274 (standard deviation (SD) $2071), underscoring the device specific cost estimation of FDs over SAC in their treatment. For giant aneurysms, the mean cost difference increased to $6396 (SD $2694), indicating FDs as the more economically sound choice. CONCLUSION: Our study indicated that, for the treatment of giant aneurysms and some large aneurysms, the FD intervention was more economical than SAC.

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This study aimed to evaluate the response of Toona ciliata seedlings to sublethal doses of glyphosate. The increasing use of glyphosate in agriculture concerns the scientific community, as the drift of this pollutant into aquatic systems or atmospheric currents can affect non-target species. Therefore, we need to understand how non-target species respond to small doses of this herbicide. T. ciliata seedlings (clone BV-1110) were exposed to sublethal doses of glyphosate (0, 9.6, 19.2, 38.4, 76.8 g ae ha-1). Anatomical, physiological, and photochemical analyses were performed 60 days after herbicide application, and growth assessments were carried out after 160 days of cultivation. We found that sublethal doses of glyphosate above 19.2 g ae ha-1 induced toxicity symptoms in Toona ciliata leaves. These symptoms were mild in some cases, such as chlorosis, but severe in other cases, such as tissue necrosis. We observed a positive relationship between increased plant height and photochemical yield with plant exposure to sub-doses 9.6 and 19.2 g ae ha-1. A sublethal dose of 38.4 g ae ha-1 improved the photosynthetic rate and carboxylation efficiency. Thus, we confirmed the hypothesis of a hormetic effect when T. ciliata was exposed to sub-doses of glyphosate equal to or lower than 38.4 g ae ha-1. However, the sublethal dose of 76.8 g ae ha-1 must be considered toxic, impacting photosynthetic activity and, consequently, the height of T. ciliata. The stem diameter of T. ciliata responded positively to increasing glyphosate doses. This occurs to compensate for the negative effect of glyphosate on water absorption. Further research will provide valuable information for harnessing the potential benefits of hormesis to improve the productivity of T. ciliata.

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O objetivo do estudo é avaliar o perfil sociodemográfico, a prevalência e os fatores de risco a lesões em corredores amadores do Rio Grande do Sul. O método de coleta utilizado foi um questionário disponibilizado online. Como critérios de inclusão da pesquisa, foi estabelecido que os sujeitos devessem ser moradores do Estado do Rio Grande do Sul, estar praticando corrida de rua nos últimos 12 meses, ser maior de 18 anos e ter aceitado participar do estudo após leitura dos termos. O estudo foi aprovado pelo comitê de ética da instituição. No total participaram da pesquisa 288 corredores, sendo que 53,5% eram homens, com idade média de 38,6±10,4 anos. Dos 288, 80,5% possuíam curso superior, 66% buscavam qualidade de vida, 54,9% relataram treinar de três a quatro vezes na semana, 28,8% percorreram um volume de treino semanal de 10 a 20 km, sendo 52,1% orientados por um profissional de Educação Física. Quanto a prevalência de lesões a amostra do estudo trouxe um número bastante expressivo, onde 46,5% dos corredores tiveram algum tipo lesão. Dessas lesões, a sua maioria afetou membros inferiores, dentre as mais prevalentes 28,1% foram musculares (panturrilha 30,9% e tibial anterior/canela 23,5%) e 35,8% articulares (joelhos 53,4% e tornozelos/pés 36,9%). Os fatores de risco significativamente associados a ocorrência de lesões (p<0,05) foram ser do sexo masculino, ter uma estatura maior, não possuir doença crônica, maior tempo de prática de corrida, maior quantidade de dias de treino, um maior volume semanal, maior velocidade média, seguir planilha pronta da internet e sentir dor ou desconforto pós treino. Concluiu- se que, por meio da identificação do perfil destes corredores e um controle desses dados, pode ser possível um melhor direcionamento de ações de planejamento para prevenir a ocorrência dessas lesões na modalidade.

The objective of the study is to evaluate the sociodemographic profile, prevalence and risk factors for injuries in amateur runners in Rio Grande do Sul. The collection method used was a questionnaire available online. As research inclusion criteria, it was established that the subjects should be residents of the State of Rio Grande do Sul, be practicing street running in the last 12 months, be over 18 years old and have accepted to participate in the study after reading the terms. The study was approved by the institution's ethics committee. In total, 288 runners participated in the research, 53.5% of which were men, with a mean age of 38.6±10.4 years. Of the 288, 80.5% had a college degree, 66% were looking for quality of life, 54.9% reported training three to four times a week, 28.8% covered a weekly training volume of 10 to 20 km, with 52 .1% guided by a Physical Education professional. As for the prevalence of injuries, the study sample brought a very expressive number, where 46.5% of the runners had some type of injury. Of these injuries, most affected lower limbs, among the most prevalent, 28.1% were muscular (calf 30.9% and tibialis anterior/shin 23.5%) and 35.8% were articular (knees 53.4% and ankles/feet 36.9%). The risk factors significantly associated with the occurrence of injuries (p<0.05) were being male, having a higher stature, not having chronic disease, longer running practice, more training days, a greater volume of week, higher average speed, following a ready-made worksheet from the internet and feeling pain or discomfort after training. It was concluded that, through the identification of the profile of these runners and a control of this data, it may be possible to better target planning actions to prevent the occurrence of these injuries in the modality.

El objetivo del estudio es evaluar el perfil sociodemográfico, la prevalencia y los factores de riesgo de lesiones en corredores aficionados de Rio Grande do Sul. El método de recogida utilizado fue un cuestionario disponible en línea. Como criterios de inclusión de la investigación, se estableció que los sujetos debían ser residentes del Estado de Rio Grande do Sul, estar practicando carreras de calle en los últimos 12 meses, tener más de 18 años y haber aceptado participar en el estudio después de leer los términos. El estudio fue aprobado por el comité de ética de la institución. En total, 288 corredores participaron en la investigación, siendo el 53,5% hombres, con una edad media de 38,6±10,4 años. De los 288, el 80,5% tenía titulación universitaria, el 66% buscaba calidad de vida, el 54,9% decía entrenar de tres a cuatro veces por semana, el 28,8% realizaba un volumen de entrenamiento semanal de 10 a 20 km, siendo el 52,1% guiado por un profesional de la Educación Física. En cuanto a la prevalencia de las lesiones, la muestra del estudio arrojó una cifra muy expresiva, ya que el 46,5% de los corredores tuvo algún tipo de lesión. De estas lesiones, la mayoría afectó a los miembros inferiores, entre las más prevalentes el 28,1% fueron musculares (pantorrilla 30,9% y tibia anterior/espinilla 23,5%) y el 35,8% articulares (rodillas 53,4% y tobillos/pies 36,9%). Los factores de riesgo asociados significativamente a la aparición de lesiones (p<0,05) fueron ser varón, ser más alto, no tener una enfermedad crónica, llevar más tiempo corriendo, más días de entrenamiento, mayor volumen semanal, mayor velocidad media, seguir una hoja de entrenamiento preparada en Internet y sentir dolor o molestias después del entrenamiento. Se concluye que, por medio de la identificación del perfil de estos corredores y un control de estos datos, puede ser posible una mejor dirección de las acciones de planificación para prevenir la aparición de estas lesiones en la modalidad.

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Alzheimer's disease (AD) is characterized by the deposition of aggregated species of amyloid beta (Aß) in the brain, which leads to progressive cognitive deficits and dementia. Aß is generated by the successive cleavage of the amyloid precursor protein (APP), first by ß-site APP cleaving enzyme 1 (BACE1) and subsequently by the γ-secretase complex. Those conditions which enhace or reduce its clearance predispose to Aß aggregation and the development of AD. In vitro studies have demonstrated that Aß assemblies spark a feed-forward loop heightening Aß production. However, the underlying mechanism remains unknown. Here, we show that oligomers and fibrils of Aß enhance colocalization and physical interaction of APP and BACE1 in recycling endosomes of human neurons derived from induced pluripotent stem cells and other cell types, which leads to exacerbated amyloidogenic processing of APP and intracellular accumulation of Aß42. In cells that are overexpressing the mutant forms of APP which are unable to bind Aß or to activate Go protein, we have found that treatment with aggregated Aß fails to increase colocalization of APP with BACE1 indicating that Aß-APP/Go signaling is involved in this process. Moreover, inhibition of Gßγ subunit signaling with ßARKct or gallein prevents Aß-dependent interaction of APP and BACE1 in endosomes, ß-processing of APP, and intracellular accumulation of Aß42. Collectively, our findings uncover a signaling mechanism leading to a feed-forward loop of amyloidogenesis that might contribute to Aß pathology in the early stages of AD and suggest that gallein could have therapeutic potential.

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The objective was to evaluate the effect of the glyphosate on Hymenaea courbaril L. A randomized block design with five replications was implemented. Each experimental unit was composed of one plant in a 5 L container. The treatments were 0 "control"; 96; 240; 480; and 960 g ha-1 "corresponding to 10, 25, 50, and 100% of the commercial dose of glyphosate recommended for Caryocar brasiliense crop, respectively". The evaluations were performed at 24 h and 60 days after application. Visual and anatomical evaluations did not change regardless of the dose, while the histochemical evaluation showed an accumulation of starch grains in leaf tissues. There was an increase in the photosynthetic rate, in the electron transport rate, and in the effective quantum yield of photosystem II at 24 h after application. At 60 days after the application of the treatments, the photosynthetic rate showed a slight decrease and the transpiratory rate showed quadratic behavior. An increase in plant height was observed up to the dose of 480 g ha-1, a linear increase in stem diameter and a decrease in the number of leaves with increasing glyphosate doses. These results show that the cuticle protected the plant, and that the little absorbed glyphosate increased photosynthesis and transpiration to favor the plants. We can conclude that the H. courbaril species is able to survive after contact with glyphosate during the evaluated time, with no visual and/or anatomical damage, showing increases in growth and physiological characteristics for the tested doses.

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Objective: The aim of this study was to compare the effects of training using loads from a repetition maximum value (%1RM) and rating of perceived exertion (RPE) in elderly women. Methods: Twenty-five elderly women (60-75 years old) were randomly assigned to a group that trained using loads determined by 1RM test (G%; n = 12) or to a group that trained using loads determined by RPE (GPE; n = 13). Elderly women trained for 12 weeks using five exercises performed with 2-3 sets of 8-15 repetitions. Loads progressed from 45% to 75% of 1RM (G%) and from 13 to 18 from Rating Perceived Exertion of Borg Scale (GPE). The outcome measures, 1RM and maximum repetitions (RMs with 70% 1RM), were assessed before, between and after training programs. Results: Increased 1RM value and RMs were observed in both groups (20-42%, p < 0.001 and 56-76%, p < 0.001, respectively, for %G; and 17-56%, p < 0.001 and 47-106%, p < 0.001, respectively, for GPE), without differences between them. Conclusions: Prescribing loads using the RPE and 1RM might be similarly effective for training elderly women in order to promote strength gains. As a practical application, RPE could be an additional method to determine training loads. In spite of the promising results of the present study, it is not possible to state that the use of RPE is effective in monitoring loads during sub maximal strength training in elderly and more research must be carried out to confirm it.

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A prática de exercícios físicos é um importante componente na prevenção e tratamento de doenças crônicas não transmissíveis, além disso, parece ser um importante componente na diminuição das sensações de fadiga. O objetivo do presente estudo foi comparar e correlacionar níveis de sensação de fadiga de mulheres com distintos níveis de aptidão física. Procedimentos metodológicos: a amostra foi constituída de 45 mulheres saudáveis, sendo 15 Insuficientemente ativas (GIAT), 15 mulheres treinadas aerobicamente (GAER) e 15 mulheres treinadas em força (GFOR). A fadiga foi avaliada por meio do Questionário de Fadiga de Chalder, sendo a força máxima de membros superiores e inferiores avaliada por meio do teste de uma repetição máxima estimada (1RM), e a capacidade cardiorrespiratória por meio do teste de milha. Resultados: Os grupos treinados apresentaram valores superiores na aptidão física e valores significativamente inferiores (p<0,05) quanto aos níveis de fadiga quando comparados ao GIAT (13[6] vs 6[6] GFOR, e 5[9] pts GAER). Quando analisados os dados em grupo único (n=45), constatou-se uma moderada correlação negativa entre a variável força de membro superior (r =-0,470; p<0,001) e inferior (r=-0,416; p = 0,004) com os escores de fadiga. Pode-se concluir que mulheres treinadas tendem a ter melhores níveis de força e capacidade cardiorrespiratória, apresentando menores níveis de fadiga comparada à mulheres com prática insuficiente de atividade física.

Physical exercise is an important component in the prevention and treatment of chronic non-communicable diseases. Additionally, it seems to be an important component in decreasing feelings of fatigue. The aim of this study was to compare and correlate feelings of fatigue in women with different levels of physical fitness. Methodological procedures: The sample consisted of 45 healthy women, with 15 of them being considered insufficiently active (GIAT); 15 aerobically trained women (GAER); and 15 strength trained women (GFOR). Fatigue was evaluated using the Chalder Fatigue Questionnaire, with the maximal strength of the upper and lower limbs being assessed by the one-repetition maximum (1RM), with cardiorespiratory capacity measured by the mile test. Results: The trained groups presented higher values in physical fitness and significantly lower values (p <0.05) regarding fatigue levels when compared to GIAT (13[6] vs 6[6] GFOR; and 5[9] pts GAER). When analyzing data as a single group (n = 45), a moderate negative correlation was found between the upper limb strength (r = -0.470; p <0.001) and lower limb strength (r = -0.416; p = 0.004) values with fatigue scores. It can be concluded that trained women tend to have better levels of strength and cardiorespiratory capacity, presenting lower levels of fatigue when compared with those with insufficient practice of physical activity.

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