RESUMO
Se resumen los niveles séricos de Cobre (Cu) y Ceruloplasmina (Cp) en medicina general y particularmente en diversos procesos malignos y benignos. Se menciona la hipótesis que vincula las metástasis, el crecicmiento tumoral y la angiogénesis concomitante con la elevación del Cu sérico. Se mensionan los resultados obtenidos en 20 pacientes con melanoma maligno concluyendo que para el Estadio I una elevación brusca de Cu sérico obliga a pensar en una sistematización del proceso oncológico
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Ceruloplasmina/metabolismo , Cobre/metabolismo , Melanoma/metabolismo , Biomarcadores Tumorais , Neoplasias Cutâneas/metabolismo , Ceruloplasmina/fisiologia , Cobre/sangue , Cobre/deficiência , PrognósticoRESUMO
Se resumen los niveles séricos de Cobre (Cu) y Ceruloplasmina (Cp) en medicina general y particularmente en diversos procesos malignos y benignos. Se menciona la hipótesis que vincula las metástasis, el crecicmiento tumoral y la angiogénesis concomitante con la elevación del Cu sérico. Se mensionan los resultados obtenidos en 20 pacientes con melanoma maligno concluyendo que para el Estadio I una elevación brusca de Cu sérico obliga a pensar en una sistematización del proceso oncológico (AU)
Assuntos
Adulto , Pessoa de Meia-Idade , Idoso , Humanos , Masculino , Feminino , Biomarcadores Tumorais , Cobre/metabolismo , Ceruloplasmina/metabolismo , Melanoma/metabolismo , Neoplasias Cutâneas/metabolismo , Cobre/deficiência , Cobre/sangue , Ceruloplasmina/fisiologia , PrognósticoRESUMO
In order to avoid gentamicin toxicity trough serum concentrations when drug monitoring is not available, a correction factor for serum creatinine was calculated and evaluated. In a first group of 35 patients under aminoglycoside treatment with variable serum creatinine (SCr) values, the regression plot of SCr concentrations versus half-life (T1/2) values was established: log T1/2 = log 2.28 + 1.45 log SCr, r = 0.90, p less than 0.01. A second group of 18 patients was treated with doses of 1.0 mg/kg of gentamicin. Dose intervals equivalent to 3 T1/2 were daily adjusted. The T1/2 was calculated from SCr according to the relationship established for the patients of the first group. All the patients studied maintained trough levels within the therapeutic range.
Assuntos
Infecções Bacterianas/tratamento farmacológico , Creatinina/sangue , Gentamicinas/administração & dosagem , Adulto , Idoso , Infecções Bacterianas/sangue , Relação Dose-Resposta a Droga , Esquema de Medicação , Gentamicinas/farmacocinética , Taxa de Filtração Glomerular , Meia-Vida , Humanos , Pessoa de Meia-IdadeRESUMO
The presence of organochlorinated pesticides in water samples drawn in the Argentine Antarctic Sector and Atlantic coastline has been proved. In general, these samples showed quantities that varied between a few hundredths of a ppmm to slightly more than 1 ppmm, although in some cases and for certain pesticides, depending on the locations, the levels found were definitely higher. With the exception of Dieldrin, which appeared in only one sample/in what would seem to be its course few hundredths of a ppm, to slightly more than 1 ppmm, although in some cases and for certain pesticides found were the same as those reported in previous investigations. The isolated cases of high pesticide contents in water samples drawn at wharves and of snow in the vicinity of Almirante Brown Base show up clearly the influence of human activity on the contamination of the environment.