RESUMO
BACKGROUND: Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor. AIM: To search for VEFG in prostatic tissue. MATERIAL AND METHODS: This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients. RESULTS: PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC. CONCLUSIONS: These results would rule out VEGF as a prognostic factor in this series of patients.
Assuntos
Biomarcadores Tumorais/análise , Recidiva Local de Neoplasia/química , Próstata/química , Hiperplasia Prostática/metabolismo , Neoplasias da Próstata/química , Fator A de Crescimento do Endotélio Vascular/análise , Idoso , Biópsia , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Próstata/patologia , Prostatectomia , Hiperplasia Prostática/patologia , Hiperplasia Prostática/cirurgia , Neoplasias da Próstata/patologia , Neoplasias da Próstata/cirurgiaRESUMO
Background: Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor. Aim: To search for VEFG in prostatic tissue. Material and Methods: This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients. Results: PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC. Conclusions: These results would rule out VEGF as a prognostic factor in this series of patients.
Assuntos
Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/química , Próstata/química , Hiperplasia Prostática/metabolismo , Neoplasias da Próstata/química , Biomarcadores Tumorais/análise , Fator A de Crescimento do Endotélio Vascular/análise , Biópsia , Imuno-Histoquímica , Valor Preditivo dos Testes , Próstata/patologia , Prostatectomia , Hiperplasia Prostática/patologia , Hiperplasia Prostática/cirurgia , Neoplasias da Próstata/patologia , Neoplasias da Próstata/cirurgiaRESUMO
Un análisis de 898 biopsias por congelación se presenta para mostrar su eficacia en diversos sistemas u órganos. La eficacia del método fue de 93,5 por ciento. Para órganos específicos varió entre 97,3 por ciento para la mama y 91,8 por ciento para el tracto gastrointestinal. Las indicaciones y limitaciones del procedimiento se delimitan y se discuten las responsabilidades mutuas del cirujano y el patólogo
Assuntos
Humanos , Biópsia , Secções Congeladas , Chile , Técnicas de Diagnóstico por Cirurgia , Neoplasias/diagnósticoRESUMO
Se presenta la historia clínica de un paciente con un pólipo amiloideo del estómago. Se hace un breve comentario respecto a la amiloidosis y su clasificación clínica. Se señala la necesidad de considerar esta patologia localizada al estómago, en el diagnóstico diferencial con el cáncer gástrico, en casos calificados. Se destaca también la poca frecuencia de estos casos y la escasa bibliografía al respecto