RESUMO
Resumen El lentigo maligno (LM) es una variante de melanoma in situ que se desarrolla principalmente en áreas de exposición solar crónica en pacientes de etnia blanca, de edad media-avanzada. Sin tratamiento, del 5% hasta el35% de los LM pueden progresar a un melanoma lentigo maligno (LMM). Aunque el tratamiento de elección es quirúrgico, el imiquimod aparece como una opción no invasiva viable. Suele indicarseen pacientes con tumores de gran tamaño, personas de edad avanzada o con patología de base, o que simplemente rechazan la extirpación quirúrgica de la lesión, especialmente por ser desfigurante. Se presenta una paciente con LM tratada satisfactoriamente con imiquimod tópico.
Abstract Malignant lentigo (LM) is a variant of in situ melanoma that develops mainly in areas of chronic sun exposure in middle-aged patients. Without treatment, 5% to 50% of the LM can progress to a lentigo maligna melanoma (LMM). Although the treatment of choice is surgical, imiquimod seems to be a viable and non-invasive option in patients with large tumors, elderly or people with underlying disease, or who simply reject the surgical removal of the lesion. We present a case of LM satisfactorily treated with topical imiquimod.
RESUMO
El complejo de la Esclerosis tuberosa es una afección hereditaria, que se transmite en forma autosómica dominante. Se caracteriza por convulsiones, retraso mental y manifestaciones en diversos órganos. Los signos cutáneos suelen ser determinantes para el diagnóstico de la enfermedad. Entre éstos se destaca la placa fibrosa, la que se localiza más frecuentemente en la frente, pero puede observarse en cualquier área del cuero cabelludo. Cuando está presente, suele ser el signo cutáneo inicial de la enfermedad, como ocurrió en nuestro paciente, subdiagnosticado. Su importancia radica entonces en reconocerlo como un marcador precoz y patognomónico de la enfermedad.
The complex of tuberous sclerosis is an hereditary disease that passes in the autosomal dominant way. It is characterized by convulsions, mental retardation and manifestations in different organs. The cutaneous signs are used to be determinant for the diagnosis of the illness. Among these, it is important the fibrous plaque, which is usually localized in the forehead, but it can also be observed in any area of the scalp.When it is presented, it is used to be the first cutaneous sign of the illness, and like it happened in our patient, underdiagnosed. So, the importance of the fibrous plaque lies in recognizing it as an early cutaneous marker and pathognomonic of the disease.
RESUMO
Se comunica un caso de lupus profundo en una mujer de 45 años, localizado en el tronco que inicialmente fue diagnosticado ecográfica y clínicamente como un lipoma. Efectuamos una actualización de esta infrecuente paniculitis.
A case of lupus profundus located in the trunk of a 40 years old woman, which was initially clinically and by ultrasound diagnosed as lipoma is reported. A clinical and histopathological review of this infrequent panniculitis is made.
RESUMO
Nuclear grade is considered a valuable prognostic factor in mammary carcinomas. Since the histological diagnosis of most of these tumors is made by "non expert" pathologists, it was considered interesting to find out the reproducibility of general pathologists to define the nuclear grade. In order to do this, a series of 15 mammary carcinomas, 10 of them randomly selected and 5 because they were considered difficult to classify for nuclear grade, were examined separately by 10 general pathologists. In a first round of observation, each one of them graded the cases according to their own criteria as used routinely, and for a second round they followed a written guide. An analysis of variance was applied to the data and no significant differences were found between observers, neither in the randomly selected cases nor in the total series. The written guide, surprisingly, instead of lowering the differences, increased them. Analysis of the individual performance of observers showed two of them having a great variation between both rounds of observation, and this was considered to influence the results of the whole group. Interobserver performance to discriminate high grade tumors (G3) from the rest, showed a good correlation in all the participants. These results allow us to conclude that in this series, examined by general pathologists, an acceptable reproducibility was observed, specially when high risk tumors were being identified.
Assuntos
Neoplasias da Mama/patologia , Núcleo Celular/patologia , Análise de Variância , Feminino , Humanos , Variações Dependentes do Observador , Reprodutibilidade dos TestesRESUMO
We report a 1-year-old boy with an extensive cutaneous vascular malformation, oculocutaneous pigmentation, and severe neurologic abnormalities from birth, as well as a selective IgA deficiency. Ultrastructural study demonstrated prominent endothelial cells in the luminal of the blood vessels. The diagnosis of phacomatosis pigmentovascularis type IIb seemed appropriate for this patient.
Assuntos
Vasos Sanguíneos/anormalidades , Deficiência de IgA/patologia , Transtornos da Pigmentação/patologia , Pele/irrigação sanguínea , Angiomatose/patologia , Encefalopatias/patologia , Endotélio Vascular/patologia , Oftalmopatias/patologia , Humanos , Lactente , Deficiência Intelectual/patologia , Masculino , Nevo Pigmentado/patologia , Neoplasias Cutâneas/patologiaAssuntos
Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 2/complicações , Dermatoses da Mão/etiologia , Argentina/epidemiologia , Diabetes Mellitus Tipo 1/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Dermatoses da Mão/epidemiologia , Humanos , Incidência , Masculino , Fatores SexuaisRESUMO
Se presenta un caso de neurotecoma (mixoma de vaina nerviosa) localizado en región escrotoperineal en un niño de 10 años. Se trata de un tumor benigno originado en vainas nerviosas, con carácter mixomatoso. Es una lesión infrecuente con ocasionales aspectos citológicos anormales que pueden conducir a un diagnóstico erróneo de malignidad
Assuntos
Criança , Humanos , Masculino , Mixoma/patologia , Neoplasias Cutâneas/patologiaRESUMO
Se presenta un caso de neurotecoma (mixoma de vaina nerviosa) localizado en región escrotoperineal en un niño de 10 años. Se trata de un tumor benigno originado en vainas nerviosas, con carácter mixomatoso. Es una lesión infrecuente con ocasionales aspectos citológicos anormales que pueden conducir a un diagnóstico erróneo de malignidad (AU)