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INTRODUCTION: Coffee is a complex brew that contains several bioactive compounds and some of them can influence blood pressure (BP) and endothelial function (EF), such as caffeine and chlorogenic acids (CGAs). AIM: This study aimed to evaluate the acute effects of coffee on BP and EF in individuals with hypertension on drug treatment who were habitual coffee consumers. METHODS: This randomized crossover trial assigned 16 adults with hypertension to receive three test beverages one week apart: caffeinated coffee (CC; 135 mg caffeine, 61 mg CGAs), decaffeinated coffee (DC; 5 mg caffeine, 68 mg CGAs), and water. BP was continuously evaluated from 15 min before to 90 min after test beverages by digital photoplethysmography. Reactive hyperemia index (RHI) assessed by peripheral arterial tonometry evaluated EF before and at 90 min after test beverages. At the same time points, microvascular reactivity was assessed by laser speckle contrast imaging. Repeated-measures-ANOVA evaluated the effect of time, the effect of beverage, and the interaction between time and beverage (treatment effect). RESULTS: Although the intake of CC produced a significant increase in BP and a significant decrease in RHI, these changes were also observed after the intake of DC and were not significantly different from the modifications observed after the consumption of DC and water. Microvascular reactivity did not present significant changes after the 3 beverages. CONCLUSION: CC in comparison with DC and water neither promoted an acute increase in BP nor produced an improvement or deleterious effect on EF in individuals with hypertension on drug treatment who were coffee consumers.

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Objetivo: identificar estudos na literatura nacional e internacional acerca do brincar no hospital na perspectiva do familiar da criança. Método: revisão Integrativa realizada no período de março a maio de 2022, nas fontes de informações: Scielo; LILACS e BDENF via BVS; MEDLINE via PUBMED; Scopus e o Google Scholar como estratégia adicional. Foram incluídos artigos originais, nos idiomas inglês, português e espanhol; sem recorte temporal; e que tivessem como participantes familiares e/ou acompanhantes de crianças hospitalizadas. Resultados: as famílias reconhecem o brincar como promotor na redução da ansiedade das crianças frente aos procedimentos invasivos, além de auxiliar no enfrentamento da hospitalização e na melhora do humor e comportamento delas. Também destacaram a brinquedoteca hospitalar como um importante espaço que promove distração e continuidade do desenvolvimento. Conclusão: a partir da perspectiva dos familiares acerca do brincar, a equipe de enfermagem deve incentiva-las serem coparticipante dessa atividade durante a hospitalização da criança.

Objective: to identify studies in the national and international literature about playing in the hospital from the perspective of the child's family. Method: integrative review carried out from March to May 2022, in the information sources: Scielo; LILACS and BDENF via VHL; MEDLINE via PUBMED; Scopus and Google Scholar as an additional strategy. Original articles in English, Portuguese and Spanish were included; no temporal clipping; and that had family members and/or companions of hospitalized children as participants. Results: families recognize playing as a promoter in reducing children's anxiety in the face of invasive procedures, as well as helping to cope with hospitalization and improving their mood and behavior. They also highlighted the hospital toy library as an important space that promotes distraction and continuity of development. Conclusion: from the perspective of family members about playing, the nursing team should encourage them to be a co-participant in this activity during the child's hospitalization.

Objetivos:identificar estudios en la literatura nacional e internacional sobre el juego en el hospital desde la perspectiva de la familia del niño. Método: revisión integradora realizada de marzo a mayo de 2022, en las fuentes de información: Scielo; LILACS y BDENF vía BVS; MEDLINE vía PUBMED; Scopus y Google Scholar como estrategia adicional. Se incluyeron artículos originales en inglés, portugués y español; sin recorte temporal; y que tuvo como participantes a familiares y/o acompañantes de niños hospitalizados. Resultados: las familias reconocen jugar como un promotor en la reducción de la ansiedad de los niños frente a los procedimientos invasivos, además de ayudar a sobrellevar la hospitalización y mejorar su estado de ánimo y comportamiento. También destacaron la ludoteca del hospital como un espacio importante que promueve la distracción y la continuidad del desarrollo. Conclusión: desde la perspectiva de los familiares sobre el juego, el equipo de enfermería debe incentivarlos a ser copartícipes de esa actividad durante la hospitalización del niño.

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Breast cancer is the most commonly diagnosed type of cancer among the female population worldwide. It is a disease with a high incidence and geographic distribution that negatively impacts global public health and deleteriously affect the quality of life of cancer patients. Among the new approaches, cancer immunotherapy is the most promising trend in oncology by stimulating the host's own immune system to efficiently destroy cancer cells. Recent evidence has indicated that iron oxide nanoparticles can promote the reprograming of M2 into M1 macrophages with anti-tumor effects in the tumor microenvironment. Thus, the aim of the present work was to evaluate the ability of polyaniline-coated maghemite (Pani/γ-Fe2O3) nanoparticles to modulate human macrophages in 2D monolayers and 3D multicellular breast cancer models. It was observed that Pani/γ-Fe2O3 NPs re-educated IL-10-stimulated macrophages towards a pro-inflammatory profile, decreasing the proportion of CD163+ and increasing the CD86+ proportion in 2D models. NPs were successfully taken-up by macrophages presented in the 3D model and were also able to induce an increasing in their CD86+ proportion in triple MCTs model. Overall, our findings open new perspectives on the use of Pani/γ-Fe2O3 NPs as an immunomodulatory therapy for macrophage reprogramming towards an anti-tumor M1 phenotype, providing a new tool for breast cancer immunotherapies.

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A formulação psicodinâmica é uma narrativa descritiva sobre a natureza e a etiologia dos problemas psíquicos do paciente que serve para orientar o tratamento e nortear a avaliação da mudança. Neste artigo, apresenta-se Core Conflictual Relationship Theme (Tema Central de Conflitos nos Relacionamentos; CCRT) CCRT e ilustra-se a sua aplicabilidade para sistematizar a formulação psicodinâmica de caso. Para isso, foram analisadas as três sessões iniciais de uma psicoterapia de uma paciente com transtorno de personalidade borderline. Discute-se as vantagens da aplicação do CCRT para sistematizar a formulação diagnóstica no contexto do ensino, da pesquisa e da prática clínica. Este estudo integra um projeto maior "A personalidade borderline e seu impacto nos processos de vinculação e mudança em psicoterapia psicanalítica", aprovado pelo Comitê de Ética em Pesquisa (CEP 14/184).(AU)

The psychodynamic formulation is a descriptive narrative about the nature and etiology of the patient's psychological problems that serves to guide the treatment and guide the assessment of change. In this article, Core Conflictual Relationship Theme is presented (CCRT) CCRT and its applicability to systematize the psychodynamic formulation of the case is illustrated. For this, the initial three sessions of psychotherapy of a patient with borderline personality disorder were analyzed. The advantages of applying the CCRT to systematize the diagnostic formulation in the context of teaching, research and clinical practice are discussed. This study is part of a larger project "The borderline personality and its impact on the processes of attachment and change in psychoanalytic psychotherapy", approved by the Research Ethics Committee (CEP 14/184).(AU)

La formulación psicodinámica es una narración descriptiva sobre la naturaleza y etiología de los problemas psicológicos del paciente que sirve para guiar el tratamiento y guiar la evaluación del cambio. En este artículo, se presenta el tema de relación de conflicto central (CCRT) CCRT y se ilustra su aplicabilidad para sistematizar la formulación psicodinámica del caso. Para esto, se analizaron las tres sesiones iniciales de psicoterapia de un paciente con trastorno límite de la personalidad. Se discuten las ventajas de aplicar el CCRT para sistematizar la formulación diagnóstica en el contexto de la enseñanza, la investigación y la práctica clínica. Este estudio es parte de un proyecto más amplio "La personalidad límite y su impacto en los procesos de apego y cambio en la psicoterapia psicoanalítica", aprobado por el Comité de Ética de Investigación (CEP 14/184).(AU)

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Obesity is associated with increased risk of cardiovascular disease (CVD). Body mass index (BMI) is the most used parameter for obesity screening. However, the evaluation of CVD risk in overweight individuals should include the assessment of body fat distribution and body composition. Renal transplant recipients (RTR) have a high CVD risk and frequently present weight gain and loss of lean mass. The aim of this study was to evaluate body fat distribution and body composition in overweight RTR. This cross-sectional study was conducted with 86 RTR and 86 hypertensive individuals (comparison group, CG) presenting BMI 25-35 Kg/m2 and 45-70 years. Anthropometric evaluation included BMI, waist circumference, waist-to-height ratio, and a body shape index. Body composition was evaluated with bioelectrical impedance analysis (BIA). Glomerular filtration rate was estimated (eGFR) by CKD-EPI equation. RTR group (RTRG) and CG presented similar age and BMI. RTRG when compared to CG presented lower percentage of women and eGFR; higher central adiposity; and lower values of reactance, intracellular water, body cell mass and phase angle, more consistently observed in women. This study suggests that overweight RTR present higher abdominal adiposity and impairment in BIA parameters that are sensitive indicators of impaired membrane integrity, water distribution, and body cell mass.

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Resumen Empleando un prototipo de reactor, se sintetizaron nanopartículas (NPs) de CuO a través del método de precipitación a partir de CuSO25H2O y de Cu(CH3COO)2H2O. Las NPs obtenidas fueron caracterizadas mediante XRD, FT-IR, TEM y SEM. La actividad antimicrobiana de las NPs se determinó mediante el método de difusión en placa, colocando 20 mg de NPs de CuO sobre cuatro cepas intrahospitalarias o nosocomiales aisladas de la Unidad de Cuidados Intensivos de un hospital nacional de Lima norte (Staphylococcus epidermidis, Aerococcus viridans, Ochrobactrum anthropi y Micrococcus lylae). La caracterización de las NPs de CuO demostró que las sintetizadas a partir de acetato (CuO-Acet) presentaron una fase pura de CuO, mientras que las sintetizadas a partir de sulfato (CuO-Sulf) presentaron dos fases, donde la de CuO representó más del 84%. Los dominios cristalinos del CuO-Acet y CuO-Sulf fueron 15 y 19 nm, respectivamente. Los halos de inhibición de las cepas estudiadas fueron mayores para las NPs de CuO-Sulf que para las NPs de CuO-Acet; solo para la cepa Ochrobactrum anthropi se presentaron halos similares para ambos tipos de NPs.

Abstract Using a prototype reactor, CuO nanoparticles (NPs) were synthetized through the precipitation method, starting from CuSO2 5H2O and Cu(CH3COO)2H2O. The obtained NPs were characterized by XDR, FT-IR, SEM, and TEM. The antimicrobial activity of the NPs was determined by the plate diffusion method, placing 20 mg of NPs onto four nosocomial strains obtained from north Lima national hospital Intensive-Care Unit (Staphylococcus epidermidis, Aerococcus viridans, Ochrobactrum anthropic, and Micrococcus lylae). NPs characterization revealed that those synthetized from acetate (CuO-Acet) shown pure CuO phase, while those synthetized from sulphate CuO-Sulf shown two phases where CuO was the predominant one, having more than 84%. The crystal domains for CuO-Acet and CuO-Sulf were 15 and 19 nm, respectively. The inhibition halos for the studied strains were larger for CuO-Sulf NPs than CuO-Acet NPs, only Ochrobactrum anthropi displayed similar inhibition halos for both types of NPs.

Resumo Usando um protótipo de reator, sintetizaram-se nanopartículas (NPs) de CuO pelo método de precipitação a partir de CuSO25H2O e de Cu(CH3COO)2H2O. As NPs obtidas foram caracterizadas por meio das seguintes técnicas: XRD, FT-IR, TEM e SEM. A atividade antimicrobiana das NPs foi determinada pelo método de difusão em placa, colocando 20 mg de NPs de CuO sobre quatro cepas nosocomiais isoladas de uma Unidade de Terapia Intensiva no hospital nacional de Lima norte (Staphylococcus epidermidis, Aerococcus viridans, Ochrobactrum anthropic e Micrococcus lylae). A caracterização das NPs de CuO mostrou que as nanopartículas sintetizadas a partir do acetato (CuO-Acet) apresentavam uma fase pura de CuO, enquanto que as sintetizadas a partir do sulfato (CuO-Sulf), apresentaram duas fases sendo a fase maior de CuO, com mais de 84%. Os domínios cristalinos de CuO-Acet y CuO-Sulf foram 15 e 19 nm, respectivamente. Os halos de inibição das cepas estudadas foram maiores para as NPs de CuO-Sulf do que as NPs de CuO-Acet somente para a cepa Ochrobactrum anthropi, apresentaram-se halos de inibição parecidos.

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Objetivo: compreender os sentimentos vivenciados pelos familiares ao cuidar da criança com bexiga neurogênica dependente do cateterismo. Método: pesquisa qualitativa desenvolvida em um ambulatório de pediatria de um hospital universitário, com 12 familiares. Para análise dos resultados utilizou-se a análise de conteúdo na modalidade temática. Resultados: emergiram três categorias analíticas: os medos no processo de cuidar da criança dependente do cateterismo; a negação da nova realidade; e a preocupação com a saúde futura da criança. Assim, a pesquisa aponta o quão complexo é o processo de cuidar dos familiares, pois não engloba apenas os aspectos técnicos, mas todo o envolvimento emocional dos mesmos diante da nova realidade de cuidar. Conclusão: é indispensável reconhecer e compreender os sentimentos dos familiares no processo de cuidar das crianças com bexiga neurogênica, aceitando suas fragilidades e dificuldades.

Objective: to understand the feelings experienced by family members caring for children with neurogenic bladder dependent on catheterization. Method: qualitative study of 12 family members at a university hospital pediatric clinic. Thematic content analysis was used. Results: three analytical categories emerged: fears in caring for children dependent on catheterization; denial of the new situation; and concern for the children's future health. The research thus shows how complex the process of caring for the family is, because it comprises not only technical aspects, but all their emotional involvement in the new care situation. conclusion: it is essential to recognize and understand the fears and difficulties of families caring for children with neurogenic bladder, and to accept their weaknesses and difficulties.

Objetivo: comprender los sentimientos experimentados por los miembros de la familia para cuidar del niño con vejiga neurogénica cateterismo dependientes. Método: investigación cualitativa realizada en una clínica pediátrica de un hospital universitario, con 12 miembros de la familia. Se utilizó el análisis de contenido en la modalidad temática. Resultados: surgieron tres categorías analíticas: temores en el cuidado de cateterismo hijo a cargo; la negación de la nueva realidad; y la preocupación por la salud futura del niño. Así, la investigación muestra lo complejo que es el proceso de cuidar a la familia, ya que no cubre sólo los aspectos técnicos, pero todos la implicación emocional de la misma en la nueva realidad de cuidar. Conclusión: es esencial reconocer y comprender los miedos y las dificultades de la familia en el cuidado de los niños con vejiga neurogénica, aceptar sus debilidades y dificultades.

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ABSTRACT Adding value to fruit residues is of great interest, since they can be presented as a viable solution in search of new drugs for the treatment of obesity and related diseases, due to bioactive substances, especially phenolic compounds. Thus, the objective of this study was to prepare the methanol extract of acerola bagasse flour, in order to evaluate its potential as a source of inhibitors of the enzymes α-amylase, α-glucosidase, lipase and trypsin, and determine the content of phenolic compounds by high performance liquid chromatography. Enzymatic inhibition assays were conducted in the presence or absence of simulated gastric fluid. In the methanol extract of acerola bagasse flour, the following phenolic compounds were identified: gallic acid, syringic and p-coumaric acid, catechin, epigallocatechin gallate, epicatechin and quercetin; epicatechin was the major compound. In the absence of gastric fluid, simulated enzymes had a variable inhibition of the acerola bagasse flour extract, except for lipase, which was not inhibited. In the presence of simulated gastric fluid, there was an inhibition of 170.08 IEU (Inhibited Enzyme Unit in µmol min−1 g−1) for α-amylase and 69.29 IEU for α-glucosidase, indicating that this extract shows potential as an adjuvant in the treatment of obesity and other dyslipidemia.

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As malformações congênitas resultam da formação deficiente de tecidos. E podem surgir em vários sistemas do organismo da criança, inclusive no sistema cardíaco. As crianças portadoras de cardiopatia congênita tendem a apresentar atraso no crescimento, diminuição do débito cardíaco, aumento da pressão pulmonar, recidivas de infecções respiratórias e comprometimento no quadro nutricional. Embora a correção dos defeitos cardíacos tenha evoluído de modo considerável, ainda hoje não é possível a reparação por completo de algumas anomalias. Nesse contexto, a enfermagem deve criar, com a criança e sua família, estratégias de cuidados individualizados e de acordo com suas necessidades. Ao compreender que é no contexto domiciliar que o familiar encontra os maiores desafios para dar continuidade ao cuidado de sua criança, traçaram-se, como objeto de estudo, as práticas de cuidados de mães da criança portadora de cardiopatias congênitas no domicílio. Os objetivos do estudo são compreender os sentimentos das mães no processo de cuidar da criança portadora de cardiopatia congênita e descrever suas práticas de cuidado com a criança portadora de cardiopatia congênita no domicílio. Os alicerces teóricos deste estudo estão pautados nas concepções teórico-filosóficas de Collière sobre o cuidado e nas contribuições de Cabral sobre as demandas de cuidados com a criança com necessidades especiais de saúde. Metodologia: estudo de natureza do tipo qualitativa, cujos participantes foram 13 mães de crianças portadoras de cardiopatias congênitas. O cenário foi o ambulatório pediátrico de um hospital de ensino situado no estado do Rio de Janeiro. Os dados foram analisados com base na análise de conteúdo de Bardin. Emergiram as seguintes categorias analíticas: os diferentes medos que interferem no processo de cuidar da criança; os cuidados maternos ante a sintomatologia; o acompanhamento periódico nas consultas médicas e os cuidados com as atividades diárias da criança. Conclui-se que as mães apresentam diferentes medos em função de ter um filho com cardiopatia e estes acabam influenciando-as no modo de cuidar de seus filhos. Ante o aparecimento dos sinais e sintomas da doença na criança, ora elas desenvolvem um cuidado que vise à manutenção da vida, ora cuidam da criança com vistas a limitar sua doença e ou combater suas causas. No que tange às atividades diárias de recreação, optam por proporcionar brincadeiras passivas às crianças, ou seja, aquelas que não exigem esforços físicos, pois entendem que a brincadeira ativa pode trazer algum tipo de descompensação cardíaca em seus filhos. O estudo aponta a necessidade de os enfermeiros criarem espaços para as mães expressarem seus medos, dúvidas e dificuldades diante dos cuidados com seu filho, o que pode refletir numa maior segurança para cuidar de sua criança quando no domicílio.

Congenital malformations result from poor tissue formation that might arise in several systems of child's body or at specific locations, for example, the cardiac system. Children with congenital heart disease tend to have delayed growth, because it is related to poor tissue perfusion, reduction of the cardiac output, increase of the pulmonary pressure, recurrent respiratory infections and nutritional status difficulties. Although the correction of heart defects has evolved considerably, even today it is not possible to completely repair some complex anomalies. The prognosis for many children is uncertain, and the full recovery is not always possible. In this context, nursing must create with the child and the family individualized care strategies according to their needs. In this sense, understanding that at home context the family finds the greatest challenges to continue the care of your child, it was traced as the object of this study: mothers care practices to the child with congenital heart disease at home. The objectives of the study are: to understand the feelings of mothers in the care process of a child with congenital heart disease and describe their care practices to a child with congenital heart disease at home. The theoretical foundations of this study are based in theoretical-philosophical conceptions of Collière about care and in Cabral's contributions on the care demands to the child with special health care needs. Methodology: qualitative nature study, exploratory and descriptive. The survey participants were 13 mothers of children with congenital heart disease. The setting was the outpatient pediatric care in congenital heart diseases, located in a teaching hospital in the State of Rio de Janeiro. The collected data were analyzed according to Bardin's content analysis. The following analytical categories emerged: The different fears that interfere in the child's care process; The care facing the child's symptomatology; The periodic follow up in medical consultation and Care in child's daily activities. It was concluded that mothers have different fears as a result of having a child with heart disease, influencing them in the way to take care of their children. In front of the appearance of child signs and symptoms related to the disease, sometimes they develop a care aimed at maintaining life, sometimes they take care of the child in order to limit or combat the disease and its causes. Regarding the daily activities of recreation, they choose to provide passive play to children, meaning those that do not require physical efforts. They understand that an active type of playing can bring some sort of cardiac decompensation to their children. The study points out the need of the nurses professionals to favor spaces for mothers to express their fears, doubts and difficulties in the care for their child, which might reflect a greater security to look after child when at home.

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In this study, we evaluated acute toxicity of four different pharmaceutical compounds: 17 α-ethinylestradiol (EE2), fluoxetine,diclofenac and ibuprofen to Daphnia similis. The average values of EC50 were 1.63 mg/L to the 17α-ethinylestradiol(EE2), 4.41 mg/L to the fluoxetine, 46.0 mg/L to the diclofenac and 97.0 mg/L to the ibuprofen. The effects of these drugs,in particular those caused to aquatic biota, still unknown especially at low concentrations in a range from ng/L up to mg/L.

Este estudo avaliou a toxicidade aguda de quatro diferentes fármacos: 17 α-ethinylestradiol (EE2), fluoxetina, diclofenaco eibuprofeno à Daphnia similis. Os valores médios de CE50 foram de 1,63 mg/L para 17 α-ethinylestradiol (EE2), 4,41 mg/Lpara fluoxetina, 46,0 mg/L para diclofenaco e 97,0 mg/L para ibuprofeno. Os efeitos desses fármacos, sobretudo à biotaaquática, ainda são pouco conhecidos especialmente em baixas concentrações na ordem de ng/L a mg/L.

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