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1.
Toxicol Appl Pharmacol ; 459: 116340, 2023 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-36509231

RESUMO

Several crops of agronomic interest depend on bees' pollination, and Apis mellifera L (Hymanoptera: Apidae) is the most studied direct pollinator. Nevertheless, the use of pesticides in agricultural environments is common, including fungicides. Studies that seek to evaluate the effects of fungicides on the hypopharyngeal glands of bees, the site of royal jelly synthesis, are lacking. Thus, this work aimed to evaluate the effect of field doses of fungicides (Captan SC® and Zignal®), alone or in mixture, on the hypopharyngeal glands and their subsequent effect on the strength of hives. The evaluations were carried out under field conditions in three hives per treatment. For a period of one month, bee hives received feed containing sugar syrup, pollen and 1.2 mL of Zignal® and 3 mL of Captan SC® in the isolated treatments and 4.2 mL in the mixture. The action of fungicides on the hypopharyngeal glands was determined by transmission electron microscopy analysis in bees 7 and 15 days old, collected in the hives one month after exposure to fungicides. The strength of the hives was evaluated for six months based on the number of frames with adult bees, open and closed brood, and stored food. The results indicate that fungicides promote early degeneration of the rough endoplasmic reticulum and morphological and structural changes in mitochondria. In addition, a reduction in adult population, open and closed breeding and food stock was observed. More pronounced damage occurred when bees were exposed to the mixture of fungicides. Overall, it can be concluded that the presence of fungicides in bee diets promotes harm accentuated over time and compromises the survival of hives. It will be worth estimating the fungicide effects of the queen development and on the colony heath.


Assuntos
Fungicidas Industriais , Himenópteros , Praguicidas , Abelhas , Animais , Fungicidas Industriais/toxicidade , Captana , Agricultura
4.
J Bras Nefrol ; 36(4): 502-11, 2014.
Artigo em Inglês, Português | MEDLINE | ID: mdl-25517280

RESUMO

INTRODUCTION: There are few studies about costs of inputs used in hemodialysis and among these expenditures, the compounds that make up the dialysate are one of the values considered as representative of this therapy. However, there aren't costs studies that guiding solutions. OBJECTIVE: The objective of this article is discuss whether there is wasteful of alkaline solutions in ambulatory hemodialysis and hence the possibility of reduction in cost from the standardization process simulation of establishment of dialysate flow in periods between shifts in hemodialysis outpatients. METHODS: Starting from an observational analytic, a simulation was performed twenty case scenarios, which ten cases established by standardizing processes control on the dialysate flow in recession. The combination of data was performed using as a basis the prices of three suppliers of alkali liquid or powder. RESULTS: It was observed among the scenarios with standardized processes, ranging between 7.7% and 33.3% savings in the alkaline solution cost (powder or liquid), by reducing waste. CONCLUSION: It is possible to restrain the wasteful use of alkaline solutions, both powder and liquid. Consequently, its cost from the patterning on reducing the flow of dialysate during the intervals between shifts observed in the outpatient hemodialysis. However, these results are conditional upon the commitment of health professionals, mainly to supervision exercise and control of activities in quality function deployment.


Assuntos
Álcalis/economia , Custos e Análise de Custo , Soluções para Diálise/economia , Diálise Renal/economia , Humanos , Avaliação de Processos em Cuidados de Saúde
5.
J. bras. nefrol ; 36(4): 502-511, Oct-Dec/2014. tab, graf
Artigo em Português | LILACS | ID: lil-731153

RESUMO

Introdução: São escassos estudos dos custos dos insumos consumidos em hemodiálise e, dentre estes gastos, os compostos que compõem o dialisato estão entre os valores considerados como representativos nessa terapia. Contudo, não foram encontrados estudos que orientem sobre o comportamento de custos dessas soluções. Objetivo: O objetivo do artigo é avaliar se há desperdício no consumo de soluções alcalinas em hemodiálise ambulatorial e, consequentemente, a possibilidade de redução no custo a partir da simulação de padronização no processo de estabelecimento do fluxo do dialisato nos períodos entre turnos em sessões de hemodiálise ambulatorial. Métodos: Partindo de um estudo observacional analítico, foi realizada uma simulação de 20 cenários, sendo 10 estabelecidos pela padronização dos processos de controle no fluxo do dialisato nos intervalos das sessões. A combinação dos dados foi realizada tomando por base os preços de três fornecedores de soluções alcalinas líquidas ou em pó. Resultados: Observou-se, dentre os cenários com processos padronizados, uma variação entre 7,7% e 33,3% de economia no custo da solução alcalina (em pó ou líquida), pela redução do desperdício. Conclusão: É possível refrear o desperdício no uso de soluções alcalinas, tanto em pó quanto líquidas e, consequentemente, seus custos, a partir da padronização na redução do fluxo de dialisato durante os intervalos verificados entre os turnos na hemodiálise ambulatorial. Todavia, estes resultados estão condicionados ao comprometimento de profissionais de saúde, principalmente no que tange ao exercício da supervisão e controle das atividades ...


Introduction: There are few studies about costs of inputs used in hemodialysis and among these expenditures, the compounds that make up the dialysate are one of the values considered as representative of this therapy. However, there aren’t costs studies that guiding solutions. Objective: The objective of this article is discuss whether there is wasteful of alkaline solutions in ambulatory hemodialysis and hence the possibility of reduction in cost from the standardization process simulation of establishment of dialysate flow in periods between shifts in hemodialysis outpatients. Methods: Starting from an observational analytic, a simulation was performed twenty case scenarios, which ten cases established by standardizing processes control on the dialysate flow in recession. The combination of data was performed using as a basis the prices of three suppliers of alkali liquid or powder. Results: It was observed among the scenarios with standardized processes, ranging between 7.7% and 33.3% savings in the alkaline solution cost (powder or liquid), by reducing waste. Conclusion: It is possible to restrain the wasteful use of alkaline solutions, both powder and liquid. Consequently, its cost from the patterning on reducing the flow of dialysate during the intervals between shifts observed in the outpatient hemodialysis. However, these results are conditional upon the commitment of health professionals, mainly to supervision exercise and control of activities in quality function deployment. .


Assuntos
Fusarium/metabolismo , Ouro/metabolismo , Cloretos/metabolismo , Compostos de Ouro/metabolismo , Junções Intercelulares , Microesferas , Nanotecnologia
6.
Int. arch. otorhinolaryngol. (Impr.) ; 16(4): 482-491, out.-dez. 2012. tab
Artigo em Português | LILACS | ID: lil-655975

RESUMO

Introduction: Among people affected by cancer, the impairment of quality of life of people affected by cancer can cause have devastating effects. The self-image of patients after post-laryngectomyzed patients may be find themselves compromised, affecting the quality of life in this population. Objective: To characterize quality of life in related to communication in people who have undergone went total laryngectomy surgery. Methods: This is an observational study, with a cross-sectional and descriptive series. Design of series study. The sample were comprised 15 patients interviewed the period from January to February of 2011. We used the Quality Protocol for Life Communication in Post-laryngectomy adapted from Bertocello (2004); which this questionnaire contains 55 questions. The protocol was organized from the nature of using responses classified as positive and negative aspects, proposals in with respect to five 5 communication domains: family relationships, social relationships, personal analysis; morphofunctional aspect, and use of writing. To promote and guarantee the autonomy of the respondents, was examiners made use of used assistive technology with the Visual Response Scale. Results: The responses that total laryngectomy compromises the quality of life in communication amounted to 463 occurrences (65.7%), and that who responses suggesting good quality of life were represented with amounted to 242 occurrences (34.3%), from a total of 705 occurrencesresponses. From Among the five 5 Communication domains, four 4 had percentages of above 63% for occurrences of negative content for impact on communication. Appearance Morphofunctional appearance gave the had the highest percentage of negative content, amounting to 77.3% of cases. Conclusions: The results showed important limitations of a personal and social nature due to poor communication with their peers. Thus, there is a need for multidisciplinary interventions that aim to minimize the entrapment of...


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Doenças dos Trabalhadores Agrícolas , Protocolos Clínicos , Laringectomia , Qualidade de Vida , Transtornos da Comunicação/cirurgia
7.
Int Arch Otorhinolaryngol ; 16(4): 482-91, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25991977

RESUMO

INTRODUCTION: Among people affected by cancer, the impairment of quality of life of people affected by cancer can cause have devastating effects. The self-image of patients after post-laryngectomyzed patients may be find themselves compromised, affecting the quality of life in this population. OBJECTIVE: To characterize quality of life in related to communication in people who have undergone went total laryngectomy surgery. METHODS: This is an observational study, with a cross-sectional and descriptive series. Design of series study. The sample were comprised 15 patients interviewed the period from January to February of 2011. We used the Quality Protocol for Life Communication in Post-laryngectomy adapted from Bertocello (2004); which this questionnaire contains 55 questions. The protocol was organized from the nature of using responses classified as positive and negative aspects, proposals in with respect to five 5 communication domains: family relationships, social relationships, personal analysis; morphofunctional aspect, and use of writing. To promote and guarantee the autonomy of the respondents, was examiners made use of used assistive technology with the Visual Response Scale. RESULTS: The responses that total laryngectomy compromises the quality of life in communication amounted to 463 occurrences (65.7%), and that who responses suggesting good quality of life were represented with amounted to 242 occurrences (34.3%), from a total of 705 occurrencesresponses. From Among the five 5 Communication domains, four 4 had percentages of above 63% for occurrences of negative content for impact on communication. Appearance Morphofunctional appearance gave the had the highest percentage of negative content, amounting to 77.3% of cases. CONCLUSIONS: The results showed important limitations of a personal and social nature due to poor communication with their peers. Thus, there is a need for multidisciplinary interventions that aim to minimize the entrapment of negative impact on these people communication among these patients.

8.
Braz J Otorhinolaryngol ; 77(2): 214-20, 2011.
Artigo em Inglês, Português | MEDLINE | ID: mdl-21537623

RESUMO

UNLABELLED: To improve electrocochleography's diagnostic sensitivity in Meniére's disease - new assessment methods are being studied. AIM: To determine whether or not graphic angle measurement is sensitive and specific to Menière's disease laboratorial diagnosis and if there is an increase in the electrocochleography's sensitivity and specificity when graphic angle measurements are associated with Summating Potential-Action Potential ratio (SP/AP ratio). METHODS: Electrocochleography's was used to analyze 71 ears from 55 subjects: 41 patients with clinical diagnosis of Menière's disease (MD group), and 14 healthy individuals as control (Group C). Graphic results were analyzed initially to obtain the SP/AP ratio; afterwards, through another program graphic angle measurements were calculated. RESULTS: Sensitivity and specificity values of angle measures, SP/AP ratio, and the association between them varied according to the cutoff point, the highest equilibrium between sensitivity and specificity was observed with the values of 166.25 for angle measurement and 27% for SP/AP relation; 62.79% / 60.71% and 74.42% / 67.86%, respectively. The association between measurements showed a sensitivity increase due to the specificity decrease; 88.37% and 50%, respectively. CONCLUSION: Angle graphic measurement is not sensitive and specific enough for the laboratorial diagnosis of MD. Angle graphic measurement and SP/AP ratio association proved to be higher in sensitivity, in detriment of exam specificity.


Assuntos
Audiometria de Resposta Evocada/métodos , Doença de Meniere/diagnóstico , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Estudos de Coortes , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Sensibilidade e Especificidade
9.
Braz. j. otorhinolaryngol. (Impr.) ; 77(2): 214-220, Mar.-Apr. 2011. ilus, tab
Artigo em Inglês | LILACS | ID: lil-583834

RESUMO

To improve electrocochleography's diagnostic sensitivity in Meniére's disease - new assessment methods are being studied. AIM: To determine whether or not graphic angle measurement is sensitive and specific to Menière's disease laboratorial diagnosis and if there is an increase in the electrocochleography's sensitivity and specificity when graphic angle measurements are associated with Summating Potential-Action Potential ratio (SP/AP ratio). METHODS: Electrocochleography's was used to analyze 71 ears from 55 subjects: 41 patients with clinical diagnosis of Menière's disease (MD group), and 14 healthy individuals as control (Group C). Graphic results were analyzed initially to obtain the SP/AP ratio; afterwards, through another program graphic angle measurements were calculated. RESULTS: Sensitivity and specificity values of angle measures, SP/AP ratio, and the association between them varied according to the cutoff point, the highest equilibrium between sensitivity and specificity was observed with the values of 166.25 for angle measurement and 27 percent for SP/AP relation; 62.79 percent / 60.71 percent and 74.42 percent / 67.86 percent, respectively. The association between measurements showed a sensitivity increase due to the specificity decrease; 88.37 percent and 50 percent, respectively. CONCLUSION: Angle graphic measurement is not sensitive and specific enough for the laboratorial diagnosis of MD. Angle graphic measurement and SP/AP ratio association proved to be higher in sensitivity, in detriment of exam specificity.


Para melhorar a sensibilidade diagnóstica da eletrococleografia na doença de Ménière têm-se estudado novos métodos de mensuração. OBJETIVOS: Verificar se a técnica da medida angular gráfica é sensível e específica para o diagnóstico laboratorial da doença de Ménière e se existe incremento na sensibilidade e especificidade da eletrococleografia, quando da associação da medida angular gráfica com o valor da relação SP/AP. CASUÍSTICA E MÉTODO: Foram analisadas a eletrococleografia de 71 orelhas: 41 pacientes com diagnóstico clínico de doença de Ménière e 14 controles sadios. Os traçados foram analisados inicialmente para a obtenção do valor da relação SP/AP, posteriormente foi calculada a medida angular gráfica. RESULTADOS: O valor da sensibilidade e especificidade da medida angular, da relação SP/AP e da associação de ambas variou de acordo com o ponto de corte, os valores 166,25 para a medida angular e 27 por cento para SP/AP foram os que demonstraram maior equilíbrio entre sensibilidade e especificidade, 62,79 por cento / 60,71 por cento e 74,42 por cento / 67,86 por cento, respectivamente. A associação das medidas mostrou incremento da sensibilidade à custa da diminuição da especificidade, 88,37 por cento e 50 por cento, respectivamente. CONCLUSÕES: A medida angular gráfica não é sensível e específica suficiente para o diagnóstico laboratorial DM. A associação da relação SP/AP e medida angular gráfica apresentou melhora da sensibilidade em detrimento da especificidade do exame.


Assuntos
Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Audiometria de Resposta Evocada/métodos , Doença de Meniere/diagnóstico , Estudos de Casos e Controles , Estudos de Coortes , Estudos Transversais , Valores de Referência , Sensibilidade e Especificidade
10.
Rio de Janeiro; s.n; 2011. viii,64 p. ilus, tab.
Tese em Português | LILACS | ID: lil-727984

RESUMO

O presente estudo descreve a evolução clínica dos gatos com esporotricose diagnosticados no Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos (Lapclin-Dermzoo) do Instituto de Pesquisa Clínica Evandro Chagas (IPEC)/Fiocruz, no período de 1998 a 2005. Foram revisados 1822 prontuários médicos. Novecentos gatos abandonaram o acompanhamento após o diagnóstico ou durante o tratamento. Quatrocentos e vinte e nove evoluíram para o óbito. Do total da casuística foi possível o contato telefônico com 328 (18 porcento) proprietários. Compareceram para reavaliação 73 (22,4 porcento;n=328) animais. Em dez (28,5 porcento) gatos foi isolado S. schenckii através de swab de lesão, em sete (20 porcento) swab da cavidade nasal, dois (5,7 porcento) através de swab nasal, oral e de lesão, em dois (5,7 porcento) por meio de biópsia e em 14 (40 porcento) o diagnóstico foi clínico. Trinta e cinco (47,9 porcento) gatos apresentaram ao menos uma lesão ao exame clínico. A reativação das lesões foi mais freqüente em gatos com sinais e sintomas respiratórios no momento do diagnóstico de esporotricose. Três casos reavaliados apresentaram reativação das lesões de 6 a 7 anos após a cura inicial. Do total de gatos que tiveram o tratamento abandonado, foi possível o contato com os proprietários de 147 (20,9 porcento). Foi observado que o abandono ocorreu principalmente no momento da melhora clínica, motivado pela percepção equivocada de cura por parte do proprietário. A conclusão deste estudo permitiu conhecer o alto percentual de abandono e óbitos na esporotricose felina, dificultando o seguimento dos casos por longo prazo e enfatizando a importância de investimentos em tratamento e na adesão. Também foi verificada a reativação de lesões em animais considerados curados até um longo período após a alta clínica, sugerindo a possibilidade do fungo se manter latente em cicatrizes e alertando para a necessidade do investimento em protocolos pós-tratamento


The present study describes the clinical evolution of cats with sporotrichosis seen at the Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals (Lapclin-Dermzoo) of the Evandro Chagas Clinical Research Institute (IPEC)/Fiocruz in the period of 1998 and 2005. One thousand eight hundred and twenty-two medical records were reviewed. Nineteen cats abandoned the follow-up after diagnosis orduring the treatment. Four hundred and twenty-nine died. Of the total sample, the telephone contact was possible with 328 (18 percent) owners. Seventy – three(22.4 percent;n=328) animals were re-evaluated, of which 35 (47,9 percent) with signs and symptoms of sporotrichosis. In ten (28,5 percent) cats, S. schenckii was isolated in culturefrom lesion swab, in seven (20 percent) from nasal swab, in two (5,7 percent) from lesion andnasal swabs, in two (5.7 percent) through biopsy and in fourteen (40 percent) the diagnosis was clinical. The reactivation of the lesions was more common in cats with respiratory signs and symptoms at the moment of the diagnosis of sporotrichosis. Reactivation of the lesions was observed 6 to 7 years after the initial cure in three re-evaluated cases. Of the total number of cats that had abandoned the treatment, it was possible to consult the owners of 147 (20.9 percent). It was observed that the abandonment occurred mainly at the time of clinical improvement, motivated by the wrong perception of cure by the owner. The conclusion of this study allowed to identify a high rate of abandonment and deaths in feline sporotrichosis, making difficult the follow-up at long-term and emphasizing the importance of investments in treatment and adherence. It was also verified the reactivation of lesions in animals considered cured until a long time after clinical discharge, suggesting the possibility of the fungus remain latent in scars and pointing to the need of investment in post-treatment protocols.


Assuntos
Gatos , Gatos , Esporotricose/diagnóstico , Micoses , Recidiva
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