RESUMO
Two new molecular structures, namely 1,3-bis(trimethylsilyl)-1H-benzimidazole-2(3H)-thione, C13H22N2SSi2, (2), and 1-trimethylsilyl-1H-benzimidazole-2(3H)-thione, C10H14N2SSi, (3), are reported. Both systems were derived from 1H-benzimidazole-2(3H)-thione. Noncovalent C-H···π interactions between the centroid of the benzmidazole system and the SiMe3 groups form helicoidal arrangements in (2). Dimerization of (3) results in the formation of R2(2)(8) rings via N-H···S interactions, along with parallel π-π interactions between imidazole and benzene rings.
Assuntos
Benzimidazóis/química , Silanos/química , Tionas/química , Cristalografia por Raios X , Ligação de Hidrogênio , Estrutura MolecularRESUMO
Coordination compounds with cobalt(II), nickel(II), copper(II) and zinc(II) and the ligand 2,6-bis(2,6-diethylphenyliminomethyl)pyridine (L) were synthesized and fully characterized by IR and UV-Vis-NIR spectroscopy, elemental analysis, magnetic susceptibility and X-ray diffraction for two representative cases. These novel compounds were designed to study their activity as anti-proliferative drugs against different human cancer cell lines. The tridentate ligand forms heptacoordinated compounds from nitrate metallic salts, where the nitrate acts in a chelating form to complete the seven coordination positions. In vitro cell growth inhibition was measured for Co(II), Cu(II) and Zn(II) complexes, as well as for the free ligand. Upon coordination, the IC50 value of the transition-metal compounds is improved compared to the free ligand. The copper(II) and zinc(II) compounds are the most promising candidates for further in vitro and in vivo studies. The activity against colon and prostate cell lines merits further research, in views of the limited therapeutic options for such cancer types.
Assuntos
Antineoplásicos/química , Complexos de Coordenação/química , Complexos de Coordenação/toxicidade , Piridinas/química , Antineoplásicos/síntese química , Antineoplásicos/toxicidade , Linhagem Celular Tumoral , Cobalto/química , Complexos de Coordenação/síntese química , Cobre/química , Cristalografia por Raios X , Humanos , Ligantes , Espectroscopia de Ressonância Magnética , Modelos Moleculares , Níquel/química , Espectroscopia de Luz Próxima ao Infravermelho , Difração de Raios X , Zinco/químicaRESUMO
A new sulfate acid polymorph of 1,3-dihydrobenzotriazole, viz. 1,3-dihydrobenzotriazolium hydrogensulfate, C(6)H(6)N(3)+.HSO4-, differs from an existing polymorph in that the polymeric interaction between the HSO4- anions, together with different classical (D-H...A) and nonclassical (C-H...A) interactions, changes the space group.