RESUMO
Fermented whey dairy beverages are dairy products obtained by fermentation from a mixture of milk and whey. These beverages have important health benefits, which could be improved with the addition of probiotic cultures. This study assessed the protective effect of the cosupplementation of a probiotic culture (Lactobacillus casei 01) with a fermented whey dairy beverage against infection by Salmonella enterica ssp. enterica serovar Typhimurium in a murine model. Two fermented whey dairy beverages were prepared: conventional (FWB; starter culture) and probiotic (PFWB; starter and probiotic cultures). In the first set of experiments, Balb/C female mice were treated with FWB or PFWB, challenged with Salmonella Typhimurium, and analyzed for clinical signs, weight loss, and mortality for 20 d postinfection. In the second set of experiments, mice were treated with FWB or PFWB, challenged with Salmonella Typhimurium, and killed on d 10 postinfection. The liver, colon, and ileum were used for myeloperoxidase, eosinophil peroxidase, and histological analysis and translocation to the liver. The contents from the small intestine were used for secretory IgA determination. The FWB treatment showed a better effect on animal survival (70%), translocation of the pathogen to the liver (2 out of 10), histopathology (fewer lesions), and inflammation than PFWB, which presented 50% animal survival, translocation in 5 out of 10 animals, and higher lesions. The control group presented 40% animal survival, translocation in 6 out of 10 animals, and severe lesions. Therefore, FWB was deemed to have a greater protective effect against Salmonella Typhimurium infection in the murine model compared with PFWB.
Assuntos
Produtos Fermentados do Leite , Salmonelose Animal/prevenção & controle , Salmonella typhimurium , Soro do Leite , Animais , Bebidas , Feminino , Promoção da Saúde , Imunoglobulina A Secretora/análise , Inflamação/prevenção & controle , Intestino Delgado/imunologia , Intestino Delgado/patologia , Lacticaseibacillus casei/fisiologia , Fígado/microbiologia , Fígado/patologia , Camundongos , Camundongos Endogâmicos BALB C , Probióticos , Salmonelose Animal/imunologia , Salmonelose Animal/patologia , Proteínas do Soro do LeiteRESUMO
The aim of the present study was to determine the effect of a regional basic diet (RBD) on the prevalence of caries in the molar teeth of rats of both sexes aged 23 days. The animals were divided into six groups of 10 rats each receiving the following diets for 30 and 60 days after weaning: RBD, a cariogenic diet, and a commercial diet. The prevalence and penetration of caries in the molar teeth of the rats was then analyzed. The RBD produced caries in 37.5% of the teeth of animals fed 30 days, and in 83.4% of animals fed 60 days, while the cariogenic diet produced caries in 72.5% and 77.5% of the teeth of animals fed 30 and 60 days, respectively. Rats fed the RBD for 30 days had caries in the enamel in 38% of their teeth, 48% had superficial dentin caries, and 7.5% moderate dentin caries. The effect of the RBD did not differ significantly from that of the cariogenic diet in terms of the presence of caries in rats fed 60 days. The penetration depth of the caries produced by the RBD was the same as that produced by the cariogenic diet. Our results show that the RBD has the same cariogenic potential as the cariogenic diet. Since the RBD is the only option for the low-income population, there should be a study of how to compensate for the cariogenicity of this diet.
Assuntos
Cariogênicos/efeitos adversos , Cárie Dentária/etiologia , Dieta Cariogênica , Animais , Brasil , Cárie Dentária/prevenção & controle , Testes de Atividade de Cárie Dentária , Feminino , Masculino , Prevalência , Ratos , Ratos WistarRESUMO
The aim of the present study was to determine the effect of a regional basic diet (RBD) on the prevalence of caries in the molar teeth of rats of both sexes aged 23 days. The animals were divided into six groups of 10 rats each receiving the following diets for 30 and 60 days after weaning: RBD, a cariogenic diet, and a commercial diet. The prevalence and penetration of caries in the molar teeth of the rats was then analyzed. The RBD produced caries in 37.5 percent of the teeth of animals fed 30 days, and in 83.4 percent of animals fed 60 days, while the cariogenic diet produced caries in 72.5 percent and 77.5 percent of the teeth of animals fed 30 and 60 days, respectively. Rats fed the RBD for 30 days had caries in the enamel in 38 percent of their teeth, 48 percent had superficial dentin caries, and 7.5 percent moderate dentin caries. The effect of the RBD did not differ significantly from that of the cariogenic diet in terms of the presence of caries in rats fed 60 days. The penetration depth of the caries produced by the RBD was the same as that produced by the cariogenic diet. Our results show that the RBD has the same cariogenic potential as the cariogenic diet. Since the RBD is the only option for the low-income population, there should be a study of how to compensate for the cariogenicity of this diet
Assuntos
Animais , Masculino , Feminino , Ratos , Cariogênicos , Cárie Dentária , Dieta , Brasil , Cárie Dentária , Testes de Atividade de Cárie Dentária , Dieta Cariogênica , Dente Molar , Prevalência , Ratos WistarRESUMO
A partir de uma tentativa de interpretacao do conto de Thomas Mann - A morte em Veneza - o autor tenta questionar alguns aspectos clinicos e teoricos sobre o tema: Regressao Narcisica e Suicidio. Mostra no texto a personalidade narcisica previa do personagem e a crise que se sucede a partir de determinados fatos.Assinala na teoria algumas dificuldades em superpor os trabalhos sobre narcisismo, principalmente no Para Introduzir o Narcisismo, de Freud, 1914, com a continuidade teorica posterior, especialmente no Alem do Principio do Prazer, de 1920. Para resolver determinados impasses, cita Rosenfeld e outros, que tentam associar a teoria instintivista (instinto de vida, instinto de morte), com o narcisismo, assinalando neste uma vertente agressiva, invejosa, derivada diretamente do Instinto de Morte. Uma das tentativas do A. e questionar se os acontecimentos que levariam ao suicidio realmente seriam em funcao primordial da vida ou a procura magica de vida, do renascimento. A proposicao basica de trabalho e apontar as duvidas do proprio A.quanto ao tema e que seriam objeto, no seu entender, de um amplo campo de trabalho e investigacao na pratica clinica