RESUMO
Exercise intolerance, a hallmark of patients with heart failure (HF), is associated with muscle weakness. However, its causative microcirculatory and muscle characteristics among those with preserved or reduced ejection fraction (HFpEF or HFrEF) phenotype is unclear. The musculoskeletal abnormalities that could result in impaired peripheral microcirculation are sarcopenia and muscle strength reduction in HF, implying lowered oxidative capacity and perfusion affect transport and oxygen utilization during exercise, an essential task from the microvascular muscle function. Besides that, skeletal muscle microcirculatory abnormalities have also been associated with exercise intolerance in HF patients who also present skeletal muscle myopathy. This cross-sectional study aimed to compare the muscle microcirculation dynamics via near-infrared spectroscopy (NIRS) response during an isokinetic muscle strength test and ultrasound-derived parameters (echo intensity was rectus femoris muscle, while the muscle thickness parameter was measured on rectus femoris and quadriceps femoris) in heart failure patients with HFpEF and HFrEF phenotypes and different functional severities (Weber Class A, B, and C). Twenty-eight aged-matched patients with HFpEF (n = 16) and HFrEF (n = 12) were assessed. We found phenotype differences among those with Weber C severity, with HFrEF patients reaching lower oxyhemoglobin (O2Hb, µM) (-10.9 ± 3.8 vs. -23.7 ± 5.7, p = 0.029) during exercise, while HFpEF reached lower O2Hb during the recovery period (-3.0 ± 3.4 vs. 5.9 ± 2.8, p = 0.007). HFpEF with Weber Class C also presented a higher echo intensity than HFrEF patients (29.7 ± 8.4 vs. 15.1 ± 6.8, p = 0.017) among the ultrasound-derived variables. Our preliminary study revealed more pronounced impairments in local microcirculatory dynamics in HFpEF vs. HFrEF patients during a muscle strength exercise, combined with muscle-skeletal abnormalities detected via ultrasound imaging, which may help explain the commonly observed exercise intolerance in HFpEF patients.
Assuntos
Insuficiência Cardíaca , Anormalidades Musculoesqueléticas , Idoso , Estudos Transversais , Humanos , Microcirculação , Músculo Esquelético , Fenótipo , Volume Sistólico/fisiologiaRESUMO
This work was developed to evaluate the impact of the addition of proteases on the performance characteristics, egg quality, relative weight of digestive organs, and intestinal morphometry of laying hens. 390 Hy Line W36® hens were allocated into five treatments and six replicates with 13 animals. The treatments were: 1) Control (standard formulation), 2) Negative control A - NCA (nutritional reduction according to protease A matrix), 3) Negative control B - NCB (nutritional reduction according to protease B matrix), 4) NCA+protease A (0.250 g/kg of feed) and 5) NCB+protease B (0.125 g/kg of feed). Hens fed the NCA, NCB, and NCA+protease A diets showed reductions in feed intake and egg mass. The addition of protease B provided better results for egg production in both percentage and per dozen as compared to the group fed with the NCA+protease A diets. The hens subjected to diets NCA and NCB showed eggs with a reduced eggshell and thickness percentage. However, supplementation with proteases A and B improved these parameters to values similar to the controls. There was no significant effect of the treatments on the relative weight of the liver, proventricle, gizzard, pancreas, and small intestine. However, the addition of protease A resulted in a decreased value for the relative weight of the large intestine. The jejunum and ileum crypt depths were, respectively, smaller in hens fed the control diet in relation to the NCB diet and the NCA and NCB diets. As it can be concluded, Protease B supplementation provided the best performance results.(AU)
Assuntos
Animais , Peptídeo Hidrolases/fisiologia , Galinhas/fisiologia , Ingestão de Alimentos/fisiologiaRESUMO
In English literature, there are only few reports of Warthin-like papillary thyroid carcinoma. We presented three cases and provided clinical, grossing, cytological, and histological correlation. In our point of view, the diagnosis of Warthin-like papillary thyroid carcinoma is feasible based on cytomorphological aspects. Usually those cases present moderately or highly cellular smears with many atypical Hürthle cells showing obvious papillary thyroid carcinoma nuclear features and without papillary structures, even if the inflammatory background is mild.
Assuntos
Adenolinfoma/patologia , Câncer Papilífero da Tireoide/patologia , Neoplasias da Glândula Tireoide/patologia , Biópsia por Agulha Fina , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
The objective of this study was to evaluate the inclusion of cell wall of Saccharomyces cerevisiae (CWSc) and piperine in broiler rations and their effects on performance, carcass traits, blood parameters, ileal microbiota and nutrient digestibility. A randomized block design with five treatments and six replicates of 10 birds was used, totaling 300 chickens. The treatments consisted of: control ration (CR); CR + avilamycin (10 mg / kg); CR + CWSc (2.0 g / kg); CR + piperine (60 mg / kg); and CR + CWSc (2.0 g / kg) + piperine (60 mg / kg). The use of isolated piperine resulted in greater weight gain from 9 to 40 days of age (2505g). The additives CWSc and piperine conjugates influenced the lower coliform count in the ceca (4.45 CFU / g) and caused significant alterations in the biochemical serum and hepatic renal profile. The treatments had no effect on the nutrient metabolizable coefficients or on the carcass traits. There was no positive synergistic effect of the combined use of CWSc and piperine on broiler performance. The cell wall of Saccharomyces cerevisiae and piperine are effective at guaranteeing productivity, intestinal microbiota dynamics and hematological parameters; and as zootechnical additives, especially in broiler feeds free of antimicrobial performance enhancers.
Assuntos
Animais , Galinhas/anatomia & histologia , Galinhas/classificação , Galinhas/sangue , Produtos Avícolas/análise , Produtos Avícolas/classificação , Saccharomyces cerevisiaeRESUMO
The objective of this study was to evaluate the inclusion of cell wall of Saccharomyces cerevisiae (CWSc) and piperine in broiler rations and their effects on performance, carcass traits, blood parameters, ileal microbiota and nutrient digestibility. A randomized block design with five treatments and six replicates of 10 birds was used, totaling 300 chickens. The treatments consisted of: control ration (CR); CR + avilamycin (10 mg / kg); CR + CWSc (2.0 g / kg); CR + piperine (60 mg / kg); and CR + CWSc (2.0 g / kg) + piperine (60 mg / kg). The use of isolated piperine resulted in greater weight gain from 9 to 40 days of age (2505g). The additives CWSc and piperine conjugates influenced the lower coliform count in the ceca (4.45 CFU / g) and caused significant alterations in the biochemical serum and hepatic renal profile. The treatments had no effect on the nutrient metabolizable coefficients or on the carcass traits. There was no positive synergistic effect of the combined use of CWSc and piperine on broiler performance. The cell wall of Saccharomyces cerevisiae and piperine are effective at guaranteeing productivity, intestinal microbiota dynamics and hematological parameters; and as zootechnical additives, especially in broiler feeds free of antimicrobial performance enhancers.(AU)
Assuntos
Animais , Galinhas/anatomia & histologia , Galinhas/sangue , Galinhas/classificação , Produtos Avícolas/análise , Produtos Avícolas/classificação , Saccharomyces cerevisiaeRESUMO
The aim of this study was to investigate the effect of odontoplasty on apparent digestibility of diet for horses, consumption time, and particle size of feces. Nine horses were used, aged 14.5±3.3 years and weightng 531±38.7kg. The diet consisted of 1.5% of live weight (LW) in Tifton 85 hay and 0.75% of LW in concentrate for both assays. The experiment consisted of two tests of apparent digestibility using the method of total collection, before and after the odontoplasty, where the consumption time of hay and concentrate was also evaluated and the particle size of the feces was analyzed. An effect (P<0.05) of odontoplasty on the apparent digestibility coefficients of dry matter, organic matter, crude protein, neutral detergent fiber and acid detergent fiber was observed. Effect of the consumption time for the concentrate (P<0.05) was observed, but not for the forage (P<0.05). There was more retention (P<0.05) of the fecal particles in the sieves of bigger granulometry. The odontoplasty increases the digestibility of dietary nutrients and feces particle size, without changing feces quality. Animals after the procedure have shorter concentrate consumption time.(AU)
O objetivo deste estudo foi investigar o efeito da odontoplastia sobre a digestibilidade aparente de dieta para equinos, o tempo de consumo e o tamanho de partícula das fezes. Foram utilizados nove equinos, com idade de 14,5±3,3 anos e peso de 531±38,7kg. A dieta consistiu do oferecimento de 1,5% do peso vivo (PV) em feno de Tifton 85 e 0,75% do PV em concentrado para ambos os ensaios. O experimento compôs-se de dois ensaios de digestibilidade aparente pelo método de coleta total, antes e após a odontoplastia, em que também foi avaliado o tempo de consumo do feno e do concentrado e analisado o tamanho de partícula das fezes. Foi observado efeito (P<0,05) da odontoplastia sobre os coeficientes de digestibilidade aparente da matéria seca, matéria orgânica, proteína bruta, fibra em detergente neutro e fibra em detergente ácido. Verificou-se efeito do tempo de consumo para o concentrado (P<0,05), porém não se observou para o volumoso (P<0,05). Houve maior retenção (P<0,05) das partículas das fezes nas peneiras de maior granulometria. A odontoplastia aumenta a digestibilidade dos nutrientes da dieta e o tamanho de partículas nas fezes, sem alterar a qualidade destas. Animais após o procedimento apresentam menor tempo de consumo de concentrado.(AU)
Assuntos
Animais , Cavalos/metabolismo , Odontologia/veterinária , Recomendações Nutricionais , Ração AnimalRESUMO
The aim of this study was to investigate the effect of odontoplasty on apparent digestibility of diet for horses, consumption time, and particle size of feces. Nine horses were used, aged 14.5±3.3 years and weightng 531±38.7kg. The diet consisted of 1.5% of live weight (LW) in Tifton 85 hay and 0.75% of LW in concentrate for both assays. The experiment consisted of two tests of apparent digestibility using the method of total collection, before and after the odontoplasty, where the consumption time of hay and concentrate was also evaluated and the particle size of the feces was analyzed. An effect (P<0.05) of odontoplasty on the apparent digestibility coefficients of dry matter, organic matter, crude protein, neutral detergent fiber and acid detergent fiber was observed. Effect of the consumption time for the concentrate (P<0.05) was observed, but not for the forage (P<0.05). There was more retention (P<0.05) of the fecal particles in the sieves of bigger granulometry. The odontoplasty increases the digestibility of dietary nutrients and feces particle size, without changing feces quality. Animals after the procedure have shorter concentrate consumption time.(AU)
O objetivo deste estudo foi investigar o efeito da odontoplastia sobre a digestibilidade aparente de dieta para equinos, o tempo de consumo e o tamanho de partícula das fezes. Foram utilizados nove equinos, com idade de 14,5±3,3 anos e peso de 531±38,7kg. A dieta consistiu do oferecimento de 1,5% do peso vivo (PV) em feno de Tifton 85 e 0,75% do PV em concentrado para ambos os ensaios. O experimento compôs-se de dois ensaios de digestibilidade aparente pelo método de coleta total, antes e após a odontoplastia, em que também foi avaliado o tempo de consumo do feno e do concentrado e analisado o tamanho de partícula das fezes. Foi observado efeito (P<0,05) da odontoplastia sobre os coeficientes de digestibilidade aparente da matéria seca, matéria orgânica, proteína bruta, fibra em detergente neutro e fibra em detergente ácido. Verificou-se efeito do tempo de consumo para o concentrado (P<0,05), porém não se observou para o volumoso (P<0,05). Houve maior retenção (P<0,05) das partículas das fezes nas peneiras de maior granulometria. A odontoplastia aumenta a digestibilidade dos nutrientes da dieta e o tamanho de partículas nas fezes, sem alterar a qualidade destas. Animais após o procedimento apresentam menor tempo de consumo de concentrado.(AU)
Assuntos
Animais , Odontologia/veterinária , Cavalos/metabolismo , Recomendações Nutricionais , Ração AnimalRESUMO
O objetivo deste estudo foi avaliar os efeitos de diferentes níveis de energia metabolizável (EM) nos parâmetros de desempenho e características de carcaça em frangos de corte de crescimento lento (experimento 1) e crescimento rápido (experimento 2) criados em sistemas de livre acesso ao piquete. Os frangos de corte tinham de 35 a 70 dias de idade no experimento 1 e 28 a 49 dias de idade no experimento 2. Um delineamento experimental inteiramente casualizado foi usado em ambos os experimentos, com cinco tratamentos e quatro repetições, totalizando 20 unidades experimentais com 15 frangos de corte cada. Os tratamentos consistiram em rações com níveis crescentes de energia metabolizável obtido pela adição de óleo de soja na dieta basal em substituição ao ingrediente inerte areia. Os níveis de energia metabolizável estudados no experimento 1 foram 2700, 2800, 2900, 3000 e 3100 kcal/kg e, no experimento 2, foram 2800, 2900, 3000, 3100 e 3200 kcal/kg. No experimento 1, houve uma redução linear (P<0,05) no consumo com o aumento do nível de energia metabolizável e observou-se um efeito quadrático (P<0,05) na conversão alimentar, que foi estimada em 3046 kcal /kg que resultou na melhor conversão alimentar de 2.648. No experimento 2, os níveis de energia metabolizável exerceram um efeito quadrático (P<0,05) no consumo de ração e no consumo de energia metabolizável, com um consumo máximo de ração (3361,27 g) estimado em 2842 kcal EM/kg, e a ingestão máxima de energia foi estimada em 10020 kcal. A conversão alimentar diminuiu linearmente (P<0,05) com o aumento dos níveis estudados. Para melhor conversão alimentar de frangos de corte criados em um sistema de livre acesso ao piquete, os níveis de energia recomendados são os seguintes: 3046 kcal/kg para frangos de crescimento lento de 35 a 70 dias de idade, e 3200 kcal/kg para frangos de corte de crescimento rápido de 28 a 49 dias de idade.(AU)
The objective of this study was to evaluate the effects of different levels of metabolizable energy (ME) on performance parameters and carcass characteristics in slow-growing (experiment 1) and fast-growing (experiment 2) broilers in a free-range system. Were evaluated broilers from 35 to 70 days old in experiment 1 and 28 to 49 days old in experiment 2. A completely randomized experimental design was employed in both experiments, with five treatments and four replicates totaling 20 experimental units containing 15 broilers each. The treatments consisted of rations that had increasing metabolizable energy levels obtained by the substitution of soybean oil in the basal diet for the inert sand ingredient. The metabolizable energy levels studied in experiment 1 were 2700, 2800, 2900, 3000 and 3100 kcal/kg, and in experiment 2, they were 2800, 2900, 3000, 3100 and 3200 kcal/kg. In experiment 1, there was a linear (P<0,05) reduction in consumption with the increase in the metabolizable energy level, and a quadratic effect (P<0,05) on the feed conversion was observed, which was estimated as 3046 kcal/kg the level that resulted in a better feed conversion of 2.648. In experiment 2, the metabolizable energy level exerted a significant quadratic effect (P<0,05) on the feed intake and metabolizable energy consumption, with a maximum feed intake (3361.27 g) estimated for 2842 kcal/kg, and the maximum energy intake was estimated at 10020 kcal. The feed conversion decreased linearly (P<0,05) with there was an increase in the studied levels. For broilers reared in a free-range system, for better feed conversion, the recommended metabolizable energy levels are as follows: for slow-growing broilers from 35 to 70 days of age, 3046 kcal/kg, and 3200 kcal/kg is recommended for fast-growing broilers from 28 to 49 days of age.(AU)
Assuntos
Animais , Galinhas/crescimento & desenvolvimento , Galinhas/metabolismo , Ingestão de Energia , Necessidade Energética , Óleo de Soja/administração & dosagem , Ração AnimalRESUMO
O objetivo deste estudo foi avaliar os efeitos de diferentes níveis de energia metabolizável (EM) nos parâmetros de desempenho e características de carcaça em frangos de corte de crescimento lento (experimento 1) e crescimento rápido (experimento 2) criados em sistemas de livre acesso ao piquete. Os frangos de corte tinham de 35 a 70 dias de idade no experimento 1 e 28 a 49 dias de idade no experimento 2. Um delineamento experimental inteiramente casualizado foi usado em ambos os experimentos, com cinco tratamentos e quatro repetições, totalizando 20 unidades experimentais com 15 frangos de corte cada. Os tratamentos consistiram em rações com níveis crescentes de energia metabolizável obtido pela adição de óleo de soja na dieta basal em substituição ao ingrediente inerte areia. Os níveis de energia metabolizável estudados no experimento 1 foram 2700, 2800, 2900, 3000 e 3100 kcal/kg e, no experimento 2, foram 2800, 2900, 3000, 3100 e 3200 kcal/kg. No experimento 1, houve uma redução linear (P<0,05) no consumo com o aumento do nível de energia metabolizável e observou-se um efeito quadrático (P<0,05) na conversão alimentar, que foi estimada em 3046 kcal /kg que resultou na melhor conversão alimentar de 2.648. No experimento 2, os níveis de energia metabolizável exerceram um efeito quadrático (P<0,05) no consumo de ração e no consumo de energia metabolizável, com um consumo máximo de ração (3361,27 g) estimado em 2842 kcal EM/kg, e a ingestão máxima de energia foi estimada em 10020 kcal. A conversão alimentar diminuiu linearmente (P<0,05) com o aumento dos níveis estudados. Para melhor conversão alimentar de frangos de corte criados em um sistema de livre acesso ao piquete, os níveis de energia recomendados são os seguintes: 3046 kcal/kg para frangos de crescimento lento de 35 a 70 dias de idade, e 3200 kcal/kg para frangos de corte de crescimento rápido de 28 a 49 dias de idade.
The objective of this study was to evaluate the effects of different levels of metabolizable energy (ME) on performance parameters and carcass characteristics in slow-growing (experiment 1) and fast-growing (experiment 2) broilers in a free-range system. Were evaluated broilers from 35 to 70 days old in experiment 1 and 28 to 49 days old in experiment 2. A completely randomized experimental design was employed in both experiments, with five treatments and four replicates totaling 20 experimental units containing 15 broilers each. The treatments consisted of rations that had increasing metabolizable energy levels obtained by the substitution of soybean oil in the basal diet for the inert sand ingredient. The metabolizable energy levels studied in experiment 1 were 2700, 2800, 2900, 3000 and 3100 kcal/kg, and in experiment 2, they were 2800, 2900, 3000, 3100 and 3200 kcal/kg. In experiment 1, there was a linear (P<0,05) reduction in consumption with the increase in the metabolizable energy level, and a quadratic effect (P<0,05) on the feed conversion was observed, which was estimated as 3046 kcal/kg the level that resulted in a better feed conversion of 2.648. In experiment 2, the metabolizable energy level exerted a significant quadratic effect (P<0,05) on the feed intake and metabolizable energy consumption, with a maximum feed intake (3361.27 g) estimated for 2842 kcal/kg, and the maximum energy intake was estimated at 10020 kcal. The feed conversion decreased linearly (P<0,05) with there was an increase in the studied levels. For broilers reared in a free-range system, for better feed conversion, the recommended metabolizable energy levels are as follows: for slow-growing broilers from 35 to 70 days of age, 3046 kcal/kg, and 3200 kcal/kg is recommended for fast-growing broilers from 28 to 49 days of age.
Assuntos
Animais , Galinhas/crescimento & desenvolvimento , Galinhas/metabolismo , Ingestão de Energia , Necessidade Energética , Óleo de Soja/administração & dosagem , Ração AnimalRESUMO
A systematic review was conducted to evaluate the success rate of dental implants placed in the incisive canal region and the complications related to this procedure. An electronic search was performed in the PubMed, Scopus, and Web of Science databases. Articles reporting the incisive canal deflation technique or neurovascular bundle lateralization technique, with or without concomitant dental implant installation and grafting procedures, were evaluated. Ten articles met the inclusion criteria; only one retrospective study and one longitudinal clinical trial were found. A total of 91 implants were installed in this region, and implant success ranged from 84.6% to 100%. With regard to complications, three articles reported temporary sensory loss. Permanent sensory loss in the palatal mucosa region was reported in one study applying neurovascular bundle lateralization. Five studies were assessed in the quality analysis: four were of moderate quality and one was of low quality. Although a high success rate was described in the selected studies, caution is recommended when dental implants are installed in the incisive canal region due to the low level of evidence available. Regarding complications, there are no parameters for predicting the occurrence of sensory disturbances or the extent of damage with the use of incisive canal deflation or neurovascular bundle lateralization.