Assuntos
Antígenos/análise , Fibrose Cística/complicações , Hepatopatias/diagnóstico , Protrombina/análise , Deficiência de Vitamina K/diagnóstico , Adolescente , Adulto , Coagulação Sanguínea , Criança , Pré-Escolar , Feminino , Humanos , Hepatopatias/complicações , Masculino , Deficiência de Vitamina K/complicaçõesRESUMO
Hypoprothrombinemia occurs in newborn infants, but it is unclear whether this is the result of reduced production of Factor II precursor or a vitamin K deficient state. In this study, 76 cord blood specimens were analyzed for functional factor coagulant activity and levels of Factor II antigen as determined by electroimmunoassay. In 40 normal term infants, CA = 30% +/- 1.6 (mean +/- SEM) and Ag = 44% +/- 2.3; in 17 normal preterm infants CA = 30% +/- 1.0 and Ag = 31% +/- 4.2; and in 50 normal adults CA = 83 +/- 3 and Ag = 91 +/- 4. In the term infants the average ratio of CA:Ag was 0.90 and in the preterm infants 0.96, both values being similar to those in adults and suggesting underproduction of the precursor form. In 19 term infants who experienced complications of pregnancy and/or delivery, the ratio was 0.76; seven of these ratios were less than 0.70 (range 0.40 to 0.69). These data show that hypoprothrombinemia is common in infant cord blood and is most marked in preterm infants. In the normal infants the CA:Ag ratios were normal, suggesting that the hypoprothrombinemia is the result of reduced production of the protein and not of vitamin K deficiency. However, term infants with complications of labor and delivery had reduced CA:Ag ratios that were suggestive of vitamin K deficiency.
Assuntos
Sangue Fetal/análise , Recém-Nascido , Protrombina/análise , Adulto , Antígenos/análise , Feminino , Humanos , Imunoeletroforese , Recém-Nascido Prematuro , Protrombina/imunologia , Vitamina K/uso terapêutico , Deficiência de Vitamina K/sangue , Sangramento por Deficiência de Vitamina K/prevenção & controleRESUMO
Serial eosinophil counts were determined in 38 hospitalized, appropriately grown premature infants whose gestational ages ranged from 27 to 35 weeks. Absolute eosinophilia (greater than 700/mm3) was documented in 76% (29/38). Eosinophilia was mild (700 to 999/mm3) in 9, moderate (1,000 to 2,999/mm3) in 17, and marked (greater than or equal to 3,000/mm3) in 3 patients. The average time of onset was day 19. Peak eosinophilia was usually seen within one week of onset and lasted an average of 16 days. A consistent relationship (r = 0.86) was found between the day of peak eosinophilia (mean = day 27) and the day on which birthweight was regained (mean = day 22). No association was apparent between the occurrence or degree of eosinophilia and gestational age, birth stress, presence of umbilical catheter, parenteral alimentation solution, and time of beginning or type or oral feeds. The data suggest that eosinophilia is strongly associated with the establishment of an anabolic state.
Assuntos
Peso Corporal , Eosinofilia/epidemiologia , Doenças do Prematuro/epidemiologia , Estudos de Avaliação como Assunto , Humanos , Recém-Nascido , Metabolismo , Fatores de TempoAssuntos
Pneumonia por Pneumocystis/tratamento farmacológico , Sulfametoxazol/uso terapêutico , Trimetoprima/uso terapêutico , Adolescente , Pré-Escolar , Combinação de Medicamentos , Feminino , Humanos , Lactente , Masculino , Sulfametoxazol/administração & dosagem , Trimetoprima/administração & dosagemAssuntos
Coagulação Intravascular Disseminada/tratamento farmacológico , Heparina/uso terapêutico , Sepse/complicações , Infecções Bacterianas/fisiopatologia , Coagulação Intravascular Disseminada/diagnóstico , Coagulação Intravascular Disseminada/etiologia , Hemostasia , Humanos , Hipotensão/complicações , Lactente , Masculino , Sepse/fisiopatologiaRESUMO
Four infants are described with kwashiorkor that was unassociated with poverty or infection as predisposing factors of their disease. The condition followed various dietary regimens deficient in protein of five weeks to seven months in duration. Features of this "sugar-bady" form of kwashiorkor included a low level of physician awareness of malnutrition as a diagnostic consideration, growth retardation, edema, muscle wasting, mental changes, and mild lymphocytosis. Initially, recovery was associated with rapid loss of weight and anemia and subsequently with weight gain and return to good health.