RESUMO

Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.

Assuntos

Alcaloides/química , Alcaloides/farmacologia , Bignoniaceae/química , Hipoglicemiantes/química , Hipoglicemiantes/farmacologia , Plantas Medicinais/química , Terpenos/química , Terpenos/farmacologia , Animais , Cristalografia por Raios X , Espectroscopia de Ressonância Magnética , Masculino , México , Modelos Moleculares , Conformação Molecular , Ratos , Ratos Sprague-Dawley , Receptores Nicotínicos/efeitos dos fármacos , Receptores Opioides/efeitos dos fármacos

RESUMO

Two biflavonoids were isolated from the EtOH extract from leaves of Ouratea spectabilis. Their structures were established to be the novel 6,6"-bigenkwanin and 7,7"-dimethoxyagathisflavone on the basis of spectroscopic data. The inhibition of bovine lens aldose reductase exerted by these biflavones has been studied.

Assuntos

Aldeído Redutase/antagonistas & inibidores , Flavonoides/farmacologia , Cristalino/enzimologia , Plantas Medicinais , Animais , Bovinos , Flavonoides/isolamento & purificação , Cinética , Estrutura Molecular , Folhas de Planta , Relação Estrutura-Atividade