RESUMO
Cervical cancer (CC) is the fourth most common cancer in women worldwide, strongly linked to high-risk human papilloma virus infection. In high-income countries, the screening programs have dramatically decreased the incidence of CC; however, the lack of accessibility to them in developing countries makes CC an important cause of mortality. Clinical stage is the most relevant prognostic factor in CC. The new FIGO staging system published in 2018 is more accurate than the previous one since it takes into account the lymph node status. In early stages, the primary treatment is surgery-with some concerns recently raised regarding minimally invasive surgery because it might decrease survival-or radiotherapy, whereas concomitant chemo-radiotherapy is the conventional approach in locally advanced stages. For recurrent or metastatic CC, the combination of chemotherapy plus bevacizumab is the preferred therapy. Immunotherapy approach based on checkpoint inhibitors is evolving as the election therapy following failure to platinum therapy.
Assuntos
Ensaios Clínicos como Assunto/normas , Guias de Prática Clínica como Assunto/normas , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/terapia , Feminino , Humanos , Oncologia , Sociedades MédicasRESUMO
This Galician consensus statement is a joint oncologists/cardiologists initiative indented to establish basic recommendations on how to prevent and to manage the cardiotoxicity in breast cancer with the aim of ensuring an optimal cardiovascular care of these patients. A clinical screening of the patients before treatment is recommended to stratify them into a determined risk group based on their intrinsic cardiovascular risk factors and those extrinsic arose from breast cancer therapy, thereby providing individualized preventive and monitoring measures. Suitable initial and ongoing assessments for patients with low and moderate/high risk and planned treatment with anthracyclines and trastuzumab are given; also, measures aimed at preventing and correcting any modifiable risk factor are pointed out .
Assuntos
Antineoplásicos/efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Cardiotoxicidade/prevenção & controle , Cardiotoxicidade/etiologia , Feminino , Humanos , Fatores de RiscoRESUMO
The increase in life expectancy in the western world means that we are faced with patients diagnosed with breast cancer in old age with increasing frequency. The management of these cases is a challenge for the oncologist, who must take into account the conditions associated with advanced age and the lack of trials in this population. In this review, we addressed the incorporation of geriatric assessment methods that may be useful in making decisions, the particular biological characteristics of breast cancer in elderly patients and their treatment in both localized and advanced disease. Finally, we collected recommendations based on scientific evidence regarding the monitoring and life-style after finishing treatment.
Assuntos
Neoplasias da Mama/terapia , Avaliação Geriátrica/métodos , Idoso , Idoso de 80 Anos ou mais , Feminino , HumanosRESUMO
The concomitant occurrence of cancer during pregnancy is a rare event. The cancers most frequently detected during pregnancy are breast, cervical, melanoma, ovarian, leukaemia and lymphoma, however the diagnosis of lung cancer during pregnancy is particularly exceptional. In this case, we report on a pregnant woman who was diagnosed with non-small-cell lung cancer and received therapy with paclitaxel and cisplatin.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Neoplasias Pulmonares/tratamento farmacológico , Complicações na Gravidez/tratamento farmacológico , Cisplatino/administração & dosagem , Feminino , Humanos , Paclitaxel/administração & dosagem , Gravidez , Resultado da GravidezRESUMO
Contiene: Algunos rasgos del imperialismo contemporaneo; Reseña de la penetracion imperialista en Bolivia; Saqueo y sobreexplotacion (1971-1978); Grupos financiero y dominaciones economicas; USAID, BID, BM, ADELA: instrumentos de penetracion y dominio imperialista; Dependencia financiera; Los seguros, otra forma del capital bancario
Assuntos
Economia , Governo , HistóriaRESUMO
Contiene: Algunos rasgos del imperialismo contemporaneo - Reseña de la penetracion imperialista en Boliva - Saqueo y sobrexplotacion (1971-1978) - Grupos financieros y dominacion economica - USAID, BID, BM; ADELA: instrumentos de penetracion y dominio imperialista - Mineria: fuente de acumulacion y capital imperialista - Dependencia financiera: el sistema financiero bancario - Los seguros, otra forma de capital bancario - Imperialismo y oligarquia - Testimonios de las empresas con capital extranjero
Assuntos
MineraçãoAssuntos
Antígenos HLA/análise , Transtornos de Fotossensibilidade/imunologia , Adolescente , Adulto , Criança , Pré-Escolar , Testes Imunológicos de Citotoxicidade , Suscetibilidade a Doenças , Feminino , Humanos , Linfócitos/imunologia , Masculino , Pessoa de Meia-Idade , Transtornos de Fotossensibilidade/etiologia , Luz SolarRESUMO
Varios autores han encontrado asociacion entre antigenos HLA y algunos padecimentos. En la dermatitis solar, es aspecto que la radiacion es desencadenante de la enfermedad. En estudios previos se ha demostrado una alta frecuencia de anticuerpos antinucleares. Se reporta en esta investigacion los hallazgos de antigenos HLA en dermatitis solar.Se estudiaron 33 pacientes, no emparentados mestizos de la Ciudad de Mexico. Empleando la tecnica de microcitotoxicidad para determinar la presencia de antigeno HLA locus A y B.Los resultados obtenidos en la problacion de estudio, se encontro, la asociacion de B15 de 30.00% contra 7,0% de la poblacion control, la X2 modificada segun Yates de una P <0,001. Se concluye: a) que existe relacion estadisticamente significativa entre dermatitis solar y el antigeno B15. b) Siendo que este antigeno esta asociado con algunos padecimientos autoinmunes, esto sugiere un mecanismo o etiologia comun