RESUMO
The spectrofluorometric determination of ibuprofen in pharmaceutical tablets, creams and syrup is described. It involves excitation at 263 nm and emission at 288 nm. the linear range is 2-73 mg L(-1). Other drugs or excipients present in the different formulations do not interfere, except in the case of chlorzoxazone containing tablets. Due to its strong absorbance in the spectral range the chlorzoxazone does interfere, so that in this case the proposed method can't be applied.
Assuntos
Anti-Inflamatórios não Esteroides/análise , Ibuprofeno/análise , Ibuprofeno/administração & dosagem , EspectrofotometriaAssuntos
Anti-Inflamatórios não Esteroides/análise , Diclofenaco/análise , Acetaminofen/química , Betametasona/química , Diclofenaco/química , Excipientes/química , Concentração de Íons de Hidrogênio , Pomadas , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Espectrometria de Fluorescência/métodos , ComprimidosRESUMO
The spectrofluorometric determination of piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2II-1,2-benzothiazine-3-carboxam ide-1, 1-dioxide] in pharmaceutical tablets is described. It involves excitation at 330 nm of an acid solution (HNO3 0.5 M) of the drug, and measurement of the fluorescence intensity at 440 nm. The linear range is 0.01-1.25 micrograms ml-1.