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Objetivo: Avaliar a taxa de cesáreas e suas principais indicações com base na classificação de Robson na Maternidade Municipal de São Vicente em 2020, um hospital público de risco habitual. Métodos: Trata-se de um estudo transversal observacional. Foram efetuadas revisão, correção e análise retrospectiva e documental da classificação de Robson na Maternidade Municipal de São Vicente. Foram analisados partos de janeiro a dezembro de 2020, dos quais foram coletadas e ordenadas as informações mais relevantes para a pesquisa. Resultados: Uma amostra de 1.627 partos foi encontrada. A taxa geral de cesáreas encontrada foi de 46,3%. A contribuição relativa dos grupos 1, 2 e 5 para a taxa de cesáreas foi de 16,8%, 13,3% e 46,8%, respectivamente, enquanto a contribuição relativa das indicações de cesáreas foi de 25,5% para parto cesáreo anterior e de 21,5% para sofrimento fetal agudo. Conclusão: Foi evidenciada alta taxa de cesáreas, e as principais indicações foram cesárea prévia e sofrimento fetal agudo. Os grupos 1, 2 e 5 da classificação de Robson foram os que mais contribuíram para essa taxa.

Objective: To evaluate the cesarean section rate and the cesarean indication rate based on Robson Classification during 2020 in Sã o Vicente's Municipal Maternity, a habitual-risk public hospital. Methods: This is a cross-sectional observational study. We have reviewed, corrected, analyzed retrospectively and documented Robson Classification in Sã o Vicente's Municipal Maternity. Births from January to December 2020 were analyzed, from which the main data for the research was collected and organized. Results: A sample of 1,627 births was found. The overall rate of cesarean section was 46.3%. The relative contribution of groups 1, 2 and 5 to the cesarean rate was 16.8%, 13.3% and 46.8%, respectively. While the cesarean indication relative contribution was 25.5% for previous cesarean and 21.5% for fetal distress. Conclusion: We found a high cesarean rate and the main indications were previous cesarean and fetal distress. Robson classification groups 1, 2 and 5 contributed the most to this rate.

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Sweet potato virus disease (SPVD) is a global constraint to sweetpotato (Ipomoea batatas) production, especially under intensive cultivation in the humid tropics such as East Africa. The objectives of this study were to develop a precision SPVD phenotyping protocol, to find new SPVD-resistant genotypes, and to standardize the first stages of screening for SPVD resistance. The first part of the protocol was based on enzyme-linked immunosorbent assay results for sweet potato chlorotic stunt virus (SPCSV) and sweet potato virus C (SPVC) with adjustments to a negative control (uninfected clone Tanzania) and was performed on a prebreeding population (VZ08) comprising 455 clones and 27 check clones graft inoculated under screenhouse conditions. The second part included field studies with 52 selected clones for SPCSV resistance from VZ08 and 8 checks. In screenhouse conditions, the resistant and susceptible check clones performed as expected; 63 clones from VZ08 exhibited lower relative absorbance values for SPCSV and SPVC than inoculated check Tanzania. Field experiments confirmed SPVD resistance of several clones selected by relative absorbance values (nine resistant clones in two locations; that is, 17.3% of the screenhouse selection), supporting the reliability of our method for SPVD-resistance selection. Two clones were promising, exhibiting high storage root yields of 28.7 to 34.9 t ha-1 and SPVD resistance, based on the proposed selection procedure. This modified serological analysis for SPVD-resistance phenotyping might lead to more efficient development of resistant varieties by reducing costs and time at early stages, and provide solid data for marker-assisted selection with a quantitative tool for classifying resistance.[Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.

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PURPOSE: To characterize the incidence, timing, and predictors of augmented renal clearance (ARC) in patients with traumatic brain injury (TBI). MATERIALS AND METHODS: In 61 patients with TBI, creatinine clearance (CrCl) was prospectively measured from urine samples, over seven days. ARC was defined as a CrCl >130 mL/min/1.73 m2 in at least one day. We compared patients with and without ARC. RESULTS: We performed 295 determinations of CrCl. ARC was present in 82% of the patients and arose in the first 2 days in 86% of them. ARC was more frequent in patients with associated injuries (100 vs. 75%, P = 0.02). There was a trend to a more aggressive resuscitation in patients with ARC but young age was the only independent predictor. Hospital length of stay was higher in ARC (15 [8-25] vs. 6 [3-19] days, P < 0.05). CONCLUSIONS: ARC is very common and has an early appearance in patients with TBI. Young age is its main determinant.

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INTRODUCTION: The main complication of the abnormally invasive placenta is massive bleeding, with transfusions required frequently. We aim to evaluate the impact of interdisciplinary management on transfusion practices in women with abnormally invasive placenta. METHODOLOGY: Clinical outcomes of women with abnormally invasive placenta treated between 2011 and 2019 were reviewed, including transfusion frequency. Patients divided into three groups: group A (women treated before the introduction of interdisciplinary management), group B (women attended to by a fixed interdisciplinary group), and group C (women with no accreta prenatal diagnosis). RESULTS: Patients with prenatal diagnosis and attended by a fixed interdisciplinary group (group B) required fewer units of red blood cells to be prepared and transfused (median number of units, 0 versus 2 in group A and 3 in group C). CONCLUSION: The participation of an interdisciplinary group, with strict standards for transfusion, reduces the frequency of use of blood substitutes during the care of women with abnormally invasive placenta.

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We report an unanticipated system of joint regulation by cyclin-dependent kinase (CDK) and mitogen-activated protein kinase (MAPK), involving collaborative multi-site phosphorylation of a single substrate. In budding yeast, the protein Ste5 controls signaling through a G1 arrest pathway. Upon cell-cycle entry, CDK inhibits Ste5 via multiple phosphorylation sites, disrupting its membrane association. Using quantitative time-lapse microscopy, we examined Ste5 membrane recruitment dynamics at different cell-cycle stages. Surprisingly, in S phase, where Ste5 recruitment should be blocked, we observed an initial recruitment followed by a steep drop-off. This delayed inhibition revealed a requirement for both CDK activity and negative feedback from the pathway MAPK Fus3. Mutagenesis, mass spectrometry, and electrophoretic analyses suggest that the CDK and MAPK modify shared sites, which are most extensively phosphorylated when both kinases are active and able to bind their docking sites on Ste5. Such collaborative phosphorylation can broaden regulatory inputs and diversify output dynamics of signaling pathways.

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Sweetpotato [Ipomoea batatas (L.) Lam] breeding is important for food security and health in East Africa (EA), and a breeding platform in Uganda provides national researchers and breeders in EA with true seed. Our objectives were to characterize genetic relationships among parental material used at the EA breeding platform. There were 135 parents and six check clones analyzed using 31 simple sequence repeat primers. An average of 7.13 alleles per primer was found, and Jaccard similarity coefficients were in the range of 0.298 to 1.00 with a mean of 0.542. Unweighted pair group cluster analysis placed most African parents in two main subclusters showing no association with morphology or geographical origin. The subclusters were also supported by principal coordinate analysis, derivative analysis of principal components, and population structure simulations. The analyzed breeding material from EA was highly genetically variable, grouped in two distinct genetic pools, and suitable to study heterosis exploiting breeding schemes.

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Objetivo: elaborar uma proposta de assistência fisioterapêutica na rede básica de saúde objetivando sistematizar esse serviço para a saúde da criança e do adolescente. Método: revisão bibliográfica/pesquisa nas bases de dados Scielo, Lilacs e Medline. Resultados: o fisioterapeuta não apenas restaura, desenvolve e conserva a capacidade física do paciente, como também previne doenças e promove orientações. Assim, propõe-se sua atuação com base em três estratégias: orientação, assistência e acompanhamento. Conclusão: o fisioterapeuta na atenção primária pode efetivar sua integração na equipe multiprofissional das UBS, no apoio matricial e programas de saúde da família.

Objective: To develop a proposal for physical therapy in primary health aiming to systematize this service to child health and adolescent. Method: literature / research in Scielo, Lilacs and Medline. Results: the therapist not only restores, develops and retains the physical ability of the patient, also prevents diseases and promotes guidelines. Thus, we propose a performance based on three strategies: guidance, assistance and support. Conclusion: the physiotherapist in primary care can accomplish their integration into multidisciplinary team of basic health units in the matrix support programs and family health.

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Tics are the most frequent movement disorder in children and they are most prevalent during the school-age years. Most tics are transitory; however, certain tics can be chronic, causing negative repercussions at school, within the family, and socially. In some cases, tics are associated with obsessive compulsive disorder, attention-deficit hyperactivity disorder (ADHD) and other conditions that require diagnosis and prompt treatment. In South America, there are no indexed studies determining the prevalence of tics in school-age children. The aim of this study was to establish the prevalence of tics in schoolchildren aged 6 to 12 years. From 16 000 students aged 6 to 12 years who were enrolled in first to fifth grade, a sample of 346 school-aged children was chosen via a multistage sampling process that randomized the educational systems in terms of proportional size and the stratification between public and private schools and adjusted for the design effect. The students were screened and those who were positive for tics underwent clinical evaluations and semistructured interviews by the researchers to determine the prevalence of the disease. The parents and teachers of 323 students returned our surveys (93.3%). One hundred thirty-eight students (42.7%) were considered positive for tics based on parents' and teachers' reports. The clinical evaluation established a 17.97% prevalence of tics (58 students), and 25 students (43.2%) also met diagnostic criteria for ADHD. Of the students with tics, 27.6% presented with transitory tics, and 72.4% presented with chronic tics. Gilles de la Tourette syndrome was detected in 11 of the children (3.4%). The average age of child with tics was 9 ± 1.5 years, and the majority of the children with tics attended third grade at a basic primary school. Children from public and private schools were equally likely to present with tics. Tics are noteworthy in our field and are associated with other neurobehavioral disorders, such as ADHD. Both tic disorders and ADHD require diagnosis and prompt treatment to promote social and school performance.

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A gravidez constitui verdadeira fase de desenvolvimento da personalidade da mulher, caracterizada por várias transformações. Este estudo se propõe a verificar a incidência de transtornos depressivos na gravidez associada à hipertensão e correlacioná-lo com as preocupações maternas relacionadas à gestação. Foram realizadas entrevistas com 20 gestantes hipertensas e aplicados o Prime-MD.. Conclui-se que na gestação associada à hipertensão a gestante se depara com o medo concreto em relação a si própria e ao bebê, gerando preocupações com o parto; com possíveis deficiências do bebê; e com os riscos da gravidez. Isso consequentemente faz com que aumente o nível de estresse e predispõe a gestante ao aparecimento de transtornos depressivos.(AU)

Pregnancy constitutes the true development phase of a woman’s personality, and is characterized by certain transformations. This study aims to verify the incidence of depressive disorders during pregnancy associated with high blood pressure, and to correlate such incidence with maternal concerns related to pregnancy. Interviews with 20 expectant, high blood pressure mothers were first carried out, and the Prime - MD was applied. The conclusion was that pregnancy associated with high blood pressure causes tangible fear in the expecting mother relating to herself as well as to her baby; it generates concerns relating to the childbirth itself, to possible birth defects in the baby, and to risks during pregnancy. This consequently imposes an increase in the level of stress, and predisposes the pregnant mother to the onset of depressive disorders.(AU)

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Ao realizar este estudo busquei conhecer a experiência das enfermeiras-chefes dos Serviços de Enfermagem na inserção da Sistematização da Assistência de Enfermagem (SAE), para desvelar quais são os significados e as expectativas desse processo para elas. Procurei conhecer o processo de implantação vivenciado e quais os fatores facilitadores e dificultadores encontrados. Os sujeitos da pesquisa foram 07 enfermeiras-chefes, que ocuparam o cargo de chefia do Serviço de Enfermagem de hospitais privados, de grande porte, do Município de São Paulo. Após a interpretação dos depoimentos e segundo a abordagem qualitativa adotada para análise dos discursos, trabalhei com 5 categorias pré-existentes, formuladas de acordo com os objetivos propostos, que foram reagrupados em subcategorias. Na categoria Significado encontramos 2 subcategorias: valorização do profissional e união dos enfermeiros. Na categoria Expectativas em relação à SAE encontramos 3 subcategorias: relacionada à equipe multidisciplinar, ao enfermeiro e à instituição. Quanto à categoria Processo de implantação da SAE, encontramos as subcategorias: inserindo o modelo, capacitando o pessoal de enfermagem, dimensionando a equipe e avaliando o modelo. Em relação à categoria Facilidades encontradas para a implantação da SAE, encontramos 5 subcategorias: relacionadas à instituição, à integração docente-assistencial, às enfermeiras, a outros profissionais, à própria SAE, encontramos 5 subcategorias: relacionadas à instituição, ao cliente, às enfermeiras, a outros profissionais e à própria SAE. A implantação da SAE nos hospitais privados se revelou, portanto, como um processo longo e contínuo, marcado por avanços e retrocessos.

When accomplishing this study, I looked for to know the experience of the male nurse-bosses of the Service of Nursing the implantation of Nursing Process, to watch wich are the meanings and the expectations of that process for them. I tried to know the process of lived implantation and which the factors that facilitated and they huindered that they had been found. The citizens of the research were 07 (seven) nurses that they occupy the position of commandes of the jobs of nursing,in private hospitals of great load in the Municipal district of São Paulo. After interpretation of the depositions ad according to the adopted qualitative for the analysis of the speech, I worked with 05 (five) categories preexistent, formulated in agreement with the proposed objectives, that were rearranged in subcategories. In the category Menat we found 04 (four) subcategories: valorization of the profession, professional development, professional commitment and the male nurses union. In the category Expectations in relation to Nursing Process found 03 (three) subcategories: related to the team multidisciplinary, top the male nurse and the institution. with relationship to the category Process of Implantation of Nursing Process we found the subcategories: adapting the model, qualifying the nursing personnel, measuring the team and evaluating the model. In relationship the category Means found for the implantation of Nursing Process, we found 06 (six) subcategories: related to the institution, to the assistencial teaching integration, to the leadership, to the male nurses, the other professionals, and to own Nursing Process. In the category Difficulties found for the implantation of Nursing Process, we found 05 (five) subcategories: related to the institution, to the client, to the males nurses, the other professionals and to own Nursing Process. The implantation of the Nursing Process in private hospitals if disclosed as a long and continous process, ,arked for advances and backtrakings.

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