RESUMO

Forty-one human T-cell lymphotropic virus type I (HTLV-1)-seropositive individuals were identified among 1,012 subjects with stored serum samples from a health and seroepidemiological survey conducted in Barbados in 1972. These 41 subjects plus 79 HTLV-1 seronegative household members were targeted in a follow-up study 20 years later. Sixteen seropositive subjects and 22 seronegative subjects were interviewed, examined, and phlebotomized. There were no changes in HTLV-1 serostatus between the 1972 and follow-up serum samples. Three (19%) of the seropositive subjects had HTLV-1-associated disorders: two with dermatitis and one with "smoldering" adult T-cell leukemia. Neurologic and immunologic function was similar in HTLV-1-seropositive and HTLV-1-seronegative subjects. HTLV-1 antibodies persist over many years, and the risk for seroconversion of household contacts is low.

Assuntos

Anticorpos Anti-HTLV-I/sangue , Infecções por HTLV-I/epidemiologia , Adolescente , Adulto , Barbados/epidemiologia , Dermatite/complicações , Feminino , Seguimentos , Infecções por HTLV-I/complicações , Infecções por HTLV-I/imunologia , Infecções por HTLV-I/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco

RESUMO

Forty-one human T-cell lymphotropic virus I (HTLV-1)-seropositive individuals were identified among 1,012 subjects with stored serum samples from a health and seroepidemiological survey conducted in Barbados in 1972. These 41 subjects plus 79 HTLV-1 seronegative household members were targeted in a follow-up study 20 years later. Sixteen seropositive subjects and 22 seronegative subjects were interviewed, examined, and phlebotomized. There were no changes in HTLV-1 serostatus between the 1972 and follow-up serum samples. Three (19 percent) of the seropositive subjects had HTLV-1 serostatus between the 1972 and follow-up serum samples. Three (19 percent) of the seropositive subjects had HTLV-1-associated disorders: two with dermatitis and one with <

Assuntos

Humanos , Masculino , Feminino , Adolescente , Adulto , Infecções por HTLV-I/complicações , Infecções por HTLV-I/epidemiologia , Infecções por HTLV-I/imunologia , Infecções por HTLV-I/fisiopatologia , Anticorpos Anti-HTLV-I/sangue , Dermatite/complicações , Seguimentos , Fatores de Risco , Barbados