RESUMO
BACKGROUND AND OBJECTIVE: Osteoporosis is associated with bone microarchitecture alterations, and the depletion of estrogen during menopause is a major contributing factor to its development. The literature highlights the noteworthy role of gut microbiota in bone metabolism, particularly in the progression of osteoporosis. Periodontal disease leads to alveolar bone loss, which may be influenced by estrogen deficiency, and this mechanism is intricately associated with an imbalance in systemic microbiota. The aim of this study was to evaluate the effects of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) and Lacticaseibacillus casei 01 (L. casei 01) administrations on an osteoporosis animal model. MATERIALS AND METHODS: Thirty-three female rats were randomly divided into three groups: control (C-OVX), C-OVX-HN019 and C-OVX-LC01. All animals were ovariectomized. In groups C-OVX-HN019 and C-OVX-LC01, the probiotics were administered for 4 months. All animals were euthanized after 16 weeks from ovariectomy. Microtomographic, histopathological and immunohistochemical examinations were conducted on periodontal tissues, whereas histomorphometry, histopathological and immunohistochemical analyses were carried out on the intestine. The levels of estradiol were assessed in blood using an immunoenzymatic assay. The data were subjected to statistical analyses (p < .05). RESULTS: The C-OVX-LC01 group exhibited a significant reduction in alveolar bone porosity and an increase in connective tissue density compared to C-OVX (p < .05). The C-OVX-HN019 and C-OVX-LC01 groups presented reduced expression of TRAP and RANKL compared to the C-OVX (p < .05). The C-OVX group presented villi defects, mild neutrophil infiltration, decrease in both villous height and intestinal crypts and reduced expression of intestinal junctional epithelium markers e-cadherin and claudin 01 compared to C-OVX-HN019 and C-OVX-LC01 (p < .05). The C-OVX group had lower estradiol levels than C-OVX-HN019 and C-OVX-LC01 (p < .05). CONCLUSION: The probiotic therapy promoted a reduction in alveolar bone destruction and intestinal permeability as well as an increase in estradiol levels in ovariectomized rats. Specifically, the probiotic strain Lacticaseibacillus casei 01 exhibited greater effectiveness compared to Bifidobacterium animalis subsp. lactis HN019, indicating strain-dependent outcomes.
Assuntos
Estradiol , Osteoporose , Ovariectomia , Probióticos , Animais , Estradiol/sangue , Probióticos/uso terapêutico , Probióticos/farmacologia , Feminino , Ratos , Osteoporose/patologia , Perda do Osso Alveolar/patologia , Perda do Osso Alveolar/prevenção & controle , Modelos Animais de Doenças , Lacticaseibacillus casei , Bifidobacterium animalis , Microtomografia por Raio-X , Processo Alveolar/patologia , Intestinos/patologia , Intestinos/microbiologia , Microbioma Gastrointestinal , Ratos WistarRESUMO
This study aimed to comparatively analyse the electromyographic activity of the masseter and temporal muscles at rest and during mandible postural clinical conditions (right and left laterality, protrusion and maximum voluntary contraction), right and left maximum molar bite forces and the masticatory efficiency of individuals with schizophrenia or mood disorders - all medicated (medicated groups) compared with control group (healthy volunteers) via electromyography. Individuals were distributed into three groups: Group I (Schizophrenia - 20 individuals), Group II (mood disorders - 20 individuals) and Group III (Control - 40 individuals). Basically, the results were only statistically significant for the clinical mandible conditions and bite force. The most unsatisfactory results were observed in the medicated groups in relation to the control group. The group with mood disorders obtained the most unsatisfactory results compared with the group with schizophrenia. It was suggested by these observations that the association of mood disorders and schizophrenia with medication has negatively affected the stomatognathic system in relation to controls when the electromyography and bite force were used for the analysis.
Assuntos
Força de Mordida , Músculo Masseter/fisiopatologia , Mastigação/fisiologia , Transtornos do Humor/fisiopatologia , Esquizofrenia/fisiopatologia , Músculo Temporal/fisiopatologia , Adulto , Estudos de Casos e Controles , Eletromiografia/métodos , Feminino , Humanos , Masculino , Músculo Masseter/efeitos dos fármacos , Pessoa de Meia-Idade , Transtornos do Humor/tratamento farmacológico , Esquizofrenia/tratamento farmacológico , Músculo Temporal/efeitos dos fármacos , Adulto JovemRESUMO
AIM: The mandibular division of the trigeminal nerve is the largest of the three major divisions of the trigeminal nerve (fifth cranial nerve). In this way, many health professionals belonged to different fields are commonly evaluating patients suffering with orofacial pain and stomatognatic dysfunction associated to this structure. But, in the most cases, it is difficult to establish a correct diagnosis due to the anatomical complexity of the head and neck surfaces, especially when the focus is the trigeminal nerve. Thus, the objective of this research was to present the anatomical variations of the mandibular nerve and its branches correlated to more common clinical situations. METHODS: For this purpose, 20 human heads were anatomically dissected, so to study their structures, an external, medial and endocranial view. RESULTS: No significant variations related to ophthalmic and maxillary nerves were observed. Anatomical variations were observed in 20% of the total human heads dissected, all related to mandibular nerve and its branches: masseter, temporal, auriculotemporal and lingual. Variations in three to seven, on the number of the following nerves ramus, masseter and temporal were described. CONCLUSIONS: According to the present data using the described methodology, it was possible to conclude that anatomical variations are present in many subjects and they can explain many clinical situations that involve the stomatognathic structures.
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Variação Genética , Nervo Mandibular/anatomia & histologia , Adulto , Nervo da Corda do Tímpano/anatomia & histologia , Dor Facial/etiologia , Humanos , Complicações Intraoperatórias/prevenção & controle , Nervo Lingual/anatomia & histologia , Traumatismos do Nervo Lingual , Masculino , Mandíbula/anatomia & histologia , Pessoa de Meia-Idade , Traumatismos do Nervo TrigêmeoRESUMO
UNLABELLED: The masseter and temporal muscles of patients with maxillary and mandibular osteoporosis were submitted to electromyographic analysis and compared with a control group. In conclusion, individuals with osteoporosis did not show significantly lower masticatory cycle performance and efficiency compared to the control group during the proposal mastications. INTRODUCTION: This study aimed to examine electromyographically the masseter and temporal muscles of patients with maxillary and mandibular osteoporosis and compare these patients with control patients. METHODS: Sixty individuals of both genders with an average age of 53.0 +/- 5 years took part in the study, distributed in two groups with 30 individuals each: (1) individuals with osteoporosis; (2) control patients during the habitual and non-habitual mastication. The electromyographic apparel used was a Myosystem-BR1-DataHomins Technology Ltda., with five channels of acquisition and electrodes active differentials. Statistical analysis of the results was performed using SPSS version 15.0 (Chicago, IL, USA). RESULTS: The result of the Student's t test indicated no significant differences (p > 0.05) between the normalized values of the ensemble average obtained in masticatory cycles in both groups. CONCLUSION: Based on the results of this study, it was concluded that individuals with osteoporosis did not show significantly lower masticatory cycle performance and efficiency compared to control subjects during the habitual and non-habitual mastications. This result is very important because it demonstrates the functionality of the complex physiological process of mastication in individuals with osteoporosis at the bones that compose the face.
Assuntos
Mandíbula/fisiopatologia , Mastigação/fisiologia , Maxila/fisiopatologia , Osteoporose/fisiopatologia , Idoso , Estudos de Casos e Controles , Eletromiografia , Feminino , Humanos , Masculino , Músculo Masseter/fisiopatologia , Pessoa de Meia-Idade , Músculo Temporal/fisiopatologiaRESUMO
INTRODUCTION: The physical activity and adequate food plays a key role in improving health and the control of diseases. OBJECTIVE: This paper aims at determining the nutritional state through anthropometric measures, socioeconomic level, the most common illnesses and type of physical activity, beyond food consumption and the place where meals are taken, of under-graduate students of the Nutrition course in UFPE. METHODS: The sample is constituted of 68 female students, of different periods and at ages between 18 and 27 years old. The process of selection of the sample was for convenience. The students voluntarily participated and answered three questionnaires, respectively, on their socioeconomic level (income of the family) and possible illnesses they had, measures of the cutaneous folds and type of practiced physical activity; register of consumed foods and local where the meals were carried. Statistical analysis was performed by absolute frequency, percentage, average and standard deviation. The margin of error used in the testing employees was 5%. RESULTS: In relation to the incomes, they had predominated above three minimum wages (86%), the parents have a predominant role in the expenditure of their study (46%), followed by the father (24%), mother (9%), husband (4%), other responsible ones (10%); 7% did not give information. The most common illnesses were: allergic rhinitis, tonsillitis, sleeplessness and intestinal constipation. The weight, the height, the index of body mass and the relation waist hip of the students were within normal standards. The abdominal circumference varied only in 2.57 cm between the studied age range. In relation to the practice of physical activities, 67% were sedentary, 20% practiced light activity and 13% moderate. In relation to where the meals are had, breakfast, in its majority (76%), was carried at home, followed by supper (56%), while lunch (41%) and snack 1 (34%), at University. Among the pupils who did not inform the place where they had their meals there was a high percentage for the big meals and a small one for the minor ones. The main kinds of consumed meals were breakfast, lunch and supper (98%). For the small meals, the values were: snack 1 (54%), snack 2 (61%), snack 3 (45%). The analysis of food consumption for three days disclosed ingestion of energy with deficit of 21% in relation to the recommended one (p < 0.001); the macro-nutrients showed percentages within the standards; the intake of fiber (11.8 g/day) was less than recommended (p < 0.001). Meat, eggs and cereals were ingested daily (for about 80%); vegetables (40%), legumes, fruits and candies (25% 30%), around four or six days a week. Roots and tubercles, salty, embedded and non alcoholic drinks were consumed from one to three days weekly (70%). Animal guts were not consumed by 50% of the studied population. CONCLUSIONS: Having analyzed all this, the studied students need to modify their food habits, acquiring knowledge on the importance of a balanced diet, as well as the practice of physical activity systematically, to prevent illnesses and attain a better quality of life.
Assuntos
Antropometria , Atividade Motora , Estado Nutricional , Estudantes , Adolescente , Adulto , Brasil , Feminino , Humanos , Fatores Socioeconômicos , UniversidadesRESUMO
AIM: This study had the goal of analyzing masseter and temporalis muscles of individuals with Eagle's Syndrome, establishing comparisons with healthy control individuals by means of electromyography, due to the importance of the masticatory musculature upon the various functions of the stomatognathic system and the effects of Eagle's syndrome on this system's functioning. METHOD: Ten women with Eagle's syndrome and ten healthy controls volunteered to participate in the study. A Myosystem I system, Prosecon Ltda (Uberlândia/MG, Brazil) with 12 channels was used Active differential electrodes were placed on the belly of both masseters and on the anterior temporalis. Firstly, rest position was registered and then the patients were instructed to clench their teeth with maximum strength for four seconds to register the Clenching at Usual Maximum Intercuspation. Next, the clinical conditions of chewing, mandible laterality, and water swallowing were performed. RESULTS: The normalized data of muscle activity during the different clinical conditions and at rest position were compared by Student's t test, considering two groups: controls and syndrome bearers. The masticatory muscles of every syndrome bearers showed hyperactivity during the analyzed clinical conditions; except for chewing, in which the right masseter did not show greater electromyographic activity. CONCLUSION: It is concluded that individuals with the syndrome showed muscular hyperactivity when compared to healthy individuals, due to the interference of the elongated styloid process, which leads to dysfunctions of the stomatognathic system in the syndrome bearers, with signs and symptoms related to craniofacial pain, dysphagia, otalgy, temporomandibular dysfunctions, and headache.