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Background: COVID-19 is still a global health issue, there is limited evidence in South America regarding laboratory biomarkers associated with severe disease. The objective of our study was to identify hematological and hemostatic changes associated with severe COVID-19. Methods: A total of 170 hospitalized patients with COVID19 were included in the study, defining their severity according to established criteria. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of p < 0.05. We analyzed the correlation between severity and biomarkers and established cut-off values for severe patients through ROC curves, estimating Odds Ratio associated with severe disease. Results: Day 1 was observed significant differences between moderate vs severe patients for leukocytes (WBC), Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and D-dimer, establishing cut-off points for each of them. The markers we found associated to risk of severe disease were WBC (OR=3.2396; p = 0.0003), NLR (OR=5.7084; p < 0.0001), PLR (OR=4.4094; p < 0.0001), Neutrophil (OR=4.1193; p < 0.0001), D-dimer (OR=2.7827; p = 0.0124). Conclusions: The results allow to establish basic laboratory biomarkers associated to severe disease, which could be used as prognostic markers.

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La expansión y consolidación de la práctica clínica basada en la evidencia ha llevado entre otras, a la necesidad de realizar una variedad cada vez mayor de tipos de revisión de la literatura científica; lo que permite avanzar en el conocimiento y comprender la amplitud de la investigación sobre un tema de interés, teniendo en cuenta que una de las propiedades del conocimiento es su carácter acumulativo. Sin embargo, la diversidad de la terminología utilizada genera confusión de términos y conceptos. El objetivo de este manuscrito fue proporcionar un listado de los tipos de revisiones de la literatura más frecuentemente utilizados con sus características y algunos ejemplos de ellas. Revisión cualitativa. Se examinaron de forma dirigida las bases de datos PubMed, WoS y Scopus, en búsqueda de términos asociados a tipos de revisiones y síntesis de la literatura científica. Se encontraron 21 tipos de revisión; y 29 variantes y sinonimias asociadas; las que ilustran los procesos de cada una de ellas. Se da una descripción general de las características de cada cual, junto con las fortalezas y debilidades percibidas. No obstante, se verificó que sólo algunos tipos de revisión poseen metodologías propias y explícitas. Este enfoque, proporciona un punto de referencia para quienes realizan o interpretan revisiones en el ámbito sanitario, y sugiere dos tipos de propuestas de clasificación.

SUMMARY: The expansion and consolidation of evidence-based clinical practice has led, among other things, to the need to carry out an increasing variety of types of literature reviews, which allows advancing in knowledge and understanding the breadth of research on a topic of interest. However, the diversity of the terminology used generates confusion of terms and concepts. The aim of this manuscript was to provide a list of the most frequently used review types with their characteristics and some examples. Qualitative review. PubMed, WoS and Scopus databases were examined in a directed way, searching for terms associated with types of reviews and syntheses of the scientific literature. Twenty-one types of review, and 29 variants and associated synonymies were found; those that illustrate the processes of each of them. An overview of the characteristics of each is given, along with perceived strengths and weaknesses. However, it was verified that only some types of review have their own explicit methodologies. This approach, provides a point of reference for those who perform or interpret reviews in the health field and suggests two classification proposals.

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BACKGROUND AND AIMS: It is reported that patients with obesity are more frequently hospitalized for COVID-19, and evidence exists that obesity is a risk factor, regardless of other comorbidities. The objective of this study was to evaluate the association of obesity with changes in laboratory biomarkers in hospitalized Chilean patients. MATERIALS AND METHODS: A total of 202 hospitalized patients (71 with obesity and 131 without obesity) with a diagnosis of COVID-19 were included in the study. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of p < 0.05. RESULTS: Significant differences in chronic respiratory pathology are observed between patients with and without obesity. The inflammatory markers CPR, ferritin, NLR, and PLR are elevated during the evaluated period, while changes in leukocyte populations are present on day 1 (eosinophils) and day 3 (lymphocytes). Finally, a persistent elevation of D-dimer level is observed, presenting significant differences on day 7 between patients with and without obesity. Obesity had a positive correlation with admission to the critical patient unit, invasive mechanical ventilation, and length of hospital stay. CONCLUSION: Patients with obesity hospitalized for COVID-19 present marked elevations of inflammatory and hemostasis parameters, with a correlation between obesity, changes in laboratory biomarkers, and the risk of adverse clinical outcomes also observed.

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Neofusicoccum parvum belongs to the Botryosphaeriaceae family, which contains endophytes and pathogens of woody plants. In this study, we isolated 11 strains from diseased tissue of Liquidambar styraciflua. Testing with Koch's postulates-followed by a molecular approach-revealed that N. parvum was the most pathogenic strain. We established an in vitro pathosystem (L. styraciflua foliar tissue-N. parvum) in order to characterize the infection process during the first 16 days. New CysRPs were identified for both organisms using public transcriptomic and genomic databases, while mRNA expression of CysRPs was analyzed by RT-qPCR. The results showed that N. parvum caused disease symptoms after 24 h that intensified over time. Through in silico analysis, 5 CysRPs were identified for each organism, revealing that all of the proteins are potentially secreted and novel, including two of N. parvum proteins containing the CFEM domain. Interestingly, the levels of the CysRPs mRNAs change during the interaction. This study reports N. parvum as a pathogen of L. styraciflua for the first time and highlights the potential involvement of CysRPs in both organisms during this interaction.

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We report a rare case of diffuse type of gastric cancer with signet ring cells in 10 years old boy who was admitted with a 12 months history with weight loss, dysphagia to solids first and to liquids later, anorexia, fatigue, dizziness, vomiting and later, with pain in the left upper quadrant. On examination, he appeared pale, malnourished, with café-au- lait spots over the trunk and extremities. Laboratory tests showed; Hb 7.5 g, albumin 2.62 g, Thevenon positive on stools. Abdominal ultrasound examination showed periaortic masses and diffuse space occupying lesions in the liver. Endoscopic examination of the stomach showed multiple elevated tumor lesions. One located at 3 cm on the subcardial region presented irregular borders, partially eroded, that bleed easily when rubbing its surface. Multiple biopsy samples were taken. They showed a diffuse gastric signet cell type carcinoma of the stomach. Immunohistochemistry was positive to CK 8. The patient died a year later with wide spread metastasis. The boy was born through a normal delivery after a normal pregnancy to a primipara mother. His family history recorded a grandmother aunt dying of gastric cancer.

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El objetivo del presente estudio fue presentar un caso extremadamente raro de adenocarcinoma gástrico difuso con células en anillo de sello en un niño de 10 años. Se presenta un niño de 10 años, con un tiempo de enfermedad de 12 meses con sintomatología de disfagia a sólidos, luego a líquidos, pérdida de peso, anorexia, astenia, mareos, vómitos y dolor en el hipocondrio izquierdo. Presenta desnutrición crónica, marcada palidez y máculas "café con leche" en tronco y extremidades. Los exámenes de laboratorio evidenciaron 7,5 gr de hemoglobina, albúmina 2,62 gr, thevenon en heces positivo. Una ecografía abdominal mostró masas periaórticas y lesiones difusas a nivel hepático. A la endoscopía se observó lesión elevada esófago-gástrica que obstruye la luz. A nivel subcardial tumoración de 3 cm de bordes irregulares, superficie erosionada y sangrante al roce. Se realizó biopsia múltiple. Murió un año después por metástasis generalizada. Nació de parto normal, de madre primigesta, con 3 500 gr de peso. Antecedentes familiares: tía abuela materna falleció de cáncer gástrico. La biopsia mostró un adenocarcinoma difuso con presencia de células en anillo de sello, PAS positivo y a la inmunohistoquímica fue positiva a la CK 8.

We report a rare case of diffuse type of gastric cancer with signet ring cells in 10 years old boy who was admitted with a 12 months history with weight loss, dysphagia to solids first and to liquids later, anorexia, fatigue, dizziness, vomiting and later, with pain in the left upper quadrant. On examination, he appeared pale, malnourished, with café-au-lait spots over the trunk and extremities. Laboratory tests showed; Hb 7.5 g, albumin 2.62 g, Thevenon positive on stools. Abdominal ultrasound examination showed periaortic masses and diffuse space occupying lesions in the liver. Endoscopic examination of the stomach showed multiple elevated tumor lesions. One located at 3 cm on the subcardial region presented irregular borders, partially eroded, that bleed easily when rubbing its surface. Multiple biopsy samples were taken. They showed a diffuse gastric signet cell type carcinoma of the stomach. Immunohistochemistry was positive to CK 8. The patient died a year later with wide spread metastasis. The boy was born through a normal delivery after a normal pregnancy to a primipara mother. His family history recorded a grandmother aunt dying of gastric cancer.

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Objetivo: Describir las condiciones y características del procedimiento de traqueotomía en una unidad de tercer nivel de atención y analizar su asociación con el desenlace registrado. Materiales y métodos: Estudio retrospectivo, observacional y descriptivo, que incluyó a los pacientes intervenidos por el Servicio de Otorrinolaringología del Centro Médico Nacional del Noroeste, Sonora, durante el período de un año agosto de 2014 al 2015. Revisión de expedientes clínicos de casos, incluyéndose 52 por considerarse completos. 57% hombres; edad promedio: 56.2 años. Se empleó estadística descriptiva para caracterizar la distribución y las diferencias se evaluaron mediante prueba de ji cuadrado y T de Student. Resultados: 71% se intervino en quirófano y 29% en la UCI, siendo esta unidad quien indicó la operación en más de la mitad de los casos (51.92%). La intubación prolongada fue la primera causa de traqueotomía (51%). En 34,61% se presentaron complicaciones y fueron en orden descendente: oclusión de cánula, enfisema periestomal, hemorragia, neumotórax bilateral, decanulación y fístula traqueoinnominada. Estas se hallaron significativamente asociadas con obesidad, intubación orotraqueal prolongada y uso de anestesia general. La mortalidad se presentó en 7,69%. Conclusiones: No se encontró diferencia significativa entre las complicaciones entre los pacientes de sala quirúrgica y cama de UCI. La ventilación mecánica prolongada fue la principal indicación para traqueotomía. La decanulación fue la principal causa de complicación; asimismo el IMC es un factor de riesgo de complicaciones. La tasa de mortalidad fue elevada con 7.69% respecto a otros estudios

Objective: To describe the conditions and characteristics of the tracheostomy procedure in a tertiary health care unit and analyze its association with the recorded outcome. Materials and methods: A retrospective, observational and descriptive study that included patients operated in the Otorhinolaryngology Unit of the Northwest National Medical Center, Sonora, from August 2014 to August 2015. Fifty-two (52) complete clinical records of consecutive series of cases were reviewed, out of which 57% were men with an average age of 56.2 years old. Descriptive statistics was used to characterize the distribution, and the differences were evaluated by chi-square test and Student's t-test. Results: Seventy-one percent (71%) of the patients underwent surgery in an operating room and 29% in the ICU. In the latter, more than half of the cases had a tracheostomy (51.92%). Prolonged intubation was the main cause of 51% of the tracheostomy procedures. Complications reached 34.61% of the cases and included the following disorders in descending order: cannula occlusion, peristomal emphysema, hemorrhage, bilateral pneumothorax, decanulation and innominate fistula. These complications were significantly associated with obesity, prolonged endotracheal intubation and general anesthesia. Mortality occurred in 7.69% of the patients. Conclusions: No significant difference was found between complications occurred in an operating room and the ICU. Prolonged mechanical ventilation was the primary indication for tracheotomy. Decannulation was the main cause of complication. Moreover, BMI was a risk factor for complications. The mortality rate was 7.69%, which was more elevated compared to other studies

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Los comportamientos contraproducentes (CCP) son acciones voluntarias y discrecionales que violan las normas organizacionales. Se describen los pasos seguidos para el desarrollo y validación de una escala para medirlos. A partir de la revisión bibliográfica, entrevistas focales y consultas con expertos se elaboró una escala preliminar que fue aplicada a 336 empleados argentinos. Del análisis factorial exploratorio emergió una estructura trifactorial, la que fue corroborada a través de un análisis factorial confirmatorio. La consistencia interna de los factores fue superior a .80. La validez discriminante se examinó mediante correlaciones con medidas de satisfacción, estrés laboral, percepciones de justicia, afectividad y deseabilidad social. Se discute la importancia de contar con instrumentos de medición que reflejen la cultura organizacional de las empresas latinoamericanas.

Counterproductive organizational behaviors (COB) are voluntary and discretionary actions that violate significant organizational norms. This article describes the steps followed for the development and validation of a scale to measure them. From the literature review, focus group, and expert opinion, a preliminary scale with 37 items was designed, which was applied to 336 Argentine employees. An exploratory factor analysis showed a three-factor structure, which was confirmed by a confirmatory factor analysis. The internal consistency of the factors was greater than .80. The discriminant validity was examined through correlations with measures of justice perceptions, affectivity, satisfaction, job stress, and social desirability. We discuss the importance to have measurement instruments that reflect the organizational culture of Latin American companies.

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La resiliencia ha sido definida como la capacidad para superar y salir fortalecido de las adversidades. Esta capacidad es evolutiva y es influenciada por factores protectivos, tanto personales como ambientales. Si bien muchos de estos factores han sido identificados, poco se sabe acerca de las complejas interacciones entre ellos y la forma que contribuyen al desarrollo de la resiliencia. Con base en la evidencia científica más reciente, el objetivo del presente trabajo fue desarrollar un modelo explicativo de la resiliencia en jóvenes y adolescentes. Cada variable introducida en el modelo asienta sus bases en la evidencia teórica o empírica publicada. Por la naturaleza de las variables incluidas (optimismo, sentido del humor, emociones positivas, bienestar, inteligencia emocional), el modelo propuesto se enmarca dentro de los lineamientos de la Psicología Positiva. Se ofrecen sugerencias teóricas, metodológicas y epistemológicas para poner a prueba el modelo...

Resilience has been defined as the ability to overcome and emerge stronger from adversity. This capability is evolutionary and is influenced by protective factors, both personal and environmental. Although many of these factors have been identified, little is known about the complex interactions between them and the way that they contribute to the development of resilience. Based on the latest scientific evidence, the objective of this work was to develop an explanatory model of resilience in youth and adolescents. Each variable introduced in the model is rooted in theoretical or empirical evidence published. By the nature of the variables included (optimism, sense of humor, positive emotions, well-being, emotional intelligence), the proposed model fits within the guidelines of Positive Psychology. Theoretical, methodological, and epistemological suggestions are offered to test the model.

Tem-se definido resiliência como a capacidade de superar as adversidades e sair delas mais fortalecido. Esta capacidade é evolutiva e é influenciada por fatores de proteção tanto pessoal como ambiental. Embora muitos desses fatores tenham sido identificados, pouco se sabe sobre as complexas interações entre eles e a maneira como contribuem para o desenvolvimento da resiliência. O bjetivo destes trabalho foi desenvolver, com base nos últimos dados científicos, um modelo explicativo da resiliência em jovens e adolescentes. Cada variável introduzida no modelo está enraizada na prova teórica ou empírica publicada. Pela natureza das variáveis incluídas (otimismo, senso de humor, emoções positivas, bem-estar e inteligência emocional), o modelo proposto enquadra-se nas diretrizes da Psicologia Positiva. Sugestões teóricas, metodológicas e epistemológicas são oferecidas para testar o modelo.

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La resiliencia ha sido definida como la capacidad para superar y salir fortalecido de las adversidades. Esta capacidad es evolutiva y es influenciada por factores protectivos, tanto personales como ambientales. Si bien muchos de estos factores han sido identificados, poco se sabe acerca de las complejas interacciones entre ellos y la forma que contribuyen al desarrollo de la resiliencia. Con base en la evidencia científica más reciente, el objetivo del presente trabajo fue desarrollar un modelo explicativo de la resiliencia en jóvenes y adolescentes. Cada variable introducida en el modelo asienta sus bases en la evidencia teórica o empírica publicada. Por la naturaleza de las variables incluidas (optimismo, sentido del humor, emociones positivas, bienestar, inteligencia emocional), el modelo propuesto se enmarca dentro de los lineamientos de la Psicología Positiva. Se ofrecen sugerencias teóricas, metodológicas y epistemológicas para poner a prueba el modelo..(AU)

Resilience has been defined as the ability to overcome and emerge stronger from adversity. This capability is evolutionary and is influenced by protective factors, both personal and environmental. Although many of these factors have been identified, little is known about the complex interactions between them and the way that they contribute to the development of resilience. Based on the latest scientific evidence, the objective of this work was to develop an explanatory model of resilience in youth and adolescents. Each variable introduced in the model is rooted in theoretical or empirical evidence published. By the nature of the variables included (optimism, sense of humor, positive emotions, well-being, emotional intelligence), the proposed model fits within the guidelines of Positive Psychology. Theoretical, methodological, and epistemological suggestions are offered to test the model.(AU)

Tem-se definido resiliência como a capacidade de superar as adversidades e sair delas mais fortalecido. Esta capacidade é evolutiva e é influenciada por fatores de proteção tanto pessoal como ambiental. Embora muitos desses fatores tenham sido identificados, pouco se sabe sobre as complexas interações entre eles e a maneira como contribuem para o desenvolvimento da resiliência. O bjetivo destes trabalho foi desenvolver, com base nos últimos dados científicos, um modelo explicativo da resiliência em jovens e adolescentes. Cada variável introduzida no modelo está enraizada na prova teórica ou empírica publicada. Pela natureza das variáveis incluídas (otimismo, senso de humor, emoções positivas, bem-estar e inteligência emocional), o modelo proposto enquadra-se nas diretrizes da Psicologia Positiva. Sugestões teóricas, metodológicas e epistemológicas são oferecidas para testar o modelo.(AU)

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