RESUMO

This paper studied the synthesis, characterization and use of the magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which was crosslinked with epichlorohydrin for subsequent incorporation of iron oxide magnetic nanoparticles. The characterization revealed that the magnetic material comprises about 10% of the hydrogel. This material is comprised of magnetite and maghemite and exhibits ferro-ferrimagnetic behavior. The average particle size is 4.2 nm. There was high incorporation efficiency of maleimides in the magnetic nanogel. The release was of sustained character and there was a greater release when an external magnetic field was applied. The mathematical model that best explained the process of drug release by the magnetic hydrogel was that of Peppas-Sahlin. The magnetic nanogel proved to be an excellent candidate for use in drug-delivery systems.

Assuntos

Antineoplásicos/química , Quitosana/análogos & derivados , Portadores de Fármacos/química , Polietilenoglicóis/química , Polietilenoimina/química , Adsorção , Animais , Antineoplásicos/metabolismo , Varredura Diferencial de Calorimetria , Bovinos , Quitosana/síntese química , Quitosana/química , Portadores de Fármacos/síntese química , Liberação Controlada de Fármacos , Epicloroidrina/química , Magnetismo , Nanopartículas de Magnetita/química , Nanogéis , Tamanho da Partícula , Soroalbumina Bovina/química , Espectroscopia de Mossbauer , Termogravimetria