RESUMO

Sheep-associated malignant catarrhal fever (SA-MCF) is a severe, frequently fatal, lymphoproliferative disease that affects a wide variety of ruminants and is caused by ovine gammaherpesvirus 2 (OvHV-2), a member of the MCF virus (MCFV) complex. The typical clinical manifestations of SA-MCF are well known and easily recognized by veterinarians, resulting in clinical diagnosis of MCF when characteristic clinical signs are present. This article describes the findings observed in cattle infected with OvHV-2 but without typical clinical manifestations of SA-MCF. Three calves with episodes of diarrhea before death and a yearling that died suddenly were investigated. Gross alterations were not suggestive of SA-MCF. Histopathology revealed a combination of proliferating vascular lesions (PVLs) and necrotizing vasculitis in three animals (two calves and the yearling); with PVLs being identified only at the carotid rete mirabile of two calves infected with OvHV-2. Additional significant histopathologic lesions included atrophic enteritis, portal lymphocytic hepatitis, interstitial pneumonia, suppurative bacterial bronchopneumonia, and pulmonary hemorrhage. An immunohistochemical assay designed to identify only antigens of MCFV revealed, positive, intralesional, intracytoplasmic immunoreactivity within epithelial cells of multiple tissues of all animals with PVLs. PCR assays amplified OvHV-2 DNA from multiple tissues of the animals that contained MCFV proteins, confirming the MCFV identified as OvHV-2. Additionally, bovine coronavirus (BCoV) nucleic acids were amplified from tissues of all animals, including the animal not infected by OvHV-2. Collectively, these findings confirmed the participation of OvHV-2 in the development of the disease patterns observed in these animals that were concomitantly infected by BCoV and provide additional confirmation that cattle can be subclinically infected with OvHV-2. Consequently, the real occurrence of OvHV-2-related disease may be more elevated than reported, since asymptomatic or subclinically infected animals are not likely to be investigated for OvHV-2. Furthermore, PVLs should be included as possible histologic indicators of OvHV-2-related diseases in ruminants.

Assuntos

RESUMO

A babesiose é causada por hematozoários, como Babesia bovis e Babesia bigemna. Os sinais clínicos encontrados são febre, depressão, anorexia, icterícia, taquicardia, taquipneia, hemoglobinúria e quando há desenvolvimento da babesiose cerebral, os animais infectados por Babesia bovis demonstram sinais neurológicos. O objetivo deste trabalho é relatar caso de babesiose cerebral em bovino jovem, atendido no Hospital Veterinário da Faculdade de Ensino Superior e Formação Integral – FAEF. Em neonatos esta enfermidade ocorre com baixa frequência, devido à transferência de imunidade passiva. A necropsia é de essencial importância para o diagnóstico e prevenção desta enfermidade nos animais.

Babesiosis is caused by hematozoa, such as Babesia bovis and Babesia bigemna. The clinical signs found are fever, depression, anorexia, jaundice, tachycardia, tachypnea, hemoglobinuria and when there is development of cerebral babesiosis, Babesia bovis infected animals show neurological signs. The objective of this work is to report case of cerebral babesiosis in young bovine, attended at the Veterinary Hospital of the Faculty of Higher Education and Integral Training - FAEF. In neonates this disease occurs with low frequency, due to the transference of passive immunity. Necropsy is of essential importance for the diagnosis and prevention of this disease in animals.

Assuntos

RESUMO

A raiva é enfermidade importante em herbívoros, sendo zoonose, de evolução rápida e sem tratamento eficaz, exigindo um rigoroso controle profilático. Foram relatados casos positivos para doença atendidos no hospital veterinário da FAEF na cidade de Garça/SP, sendo três bovinos e uma égua. De modo geral apresentaram sinais clínicos característicos da doença e nenhum animal era vacinado contra raiva. Sem respostas aos tratamentos, os animais vieram a óbito, e para diagnóstico, foi feita a coleta de material encefálico desses animais, obtendo todos positivos para raiva. O objetivo do trabalho foi apresentar casos epidemiológicos associado à literatura em relação à raiva.

Rabies is an important disease in herbivores, being zoonosis, of fast evolution and without effective treatment, demanding a strict prophylactic control. Positive cases for disease were reported at the FAEF veterinary hospital in the city of Garça / SP, with three cattle and one mare. In general, they presented characteristic clinical signs of the disease and no animals were vaccinated against rabies. Without response to the treatments, the animals died, and for diagnosis, the brain was collected from these animals, obtaining all positive for rabies. The objective of this study was to present epidemiological cases associated with the literature regarding rabies.

Assuntos

RESUMO

A raiva é enfermidade importante em herbívoros, sendo zoonose, de evolução rápida e sem tratamento eficaz, exigindo um rigoroso controle profilático. Foram relatados casos positivos para doença atendidos no hospital veterinário da FAEF na cidade de Garça/SP, sendo três bovinos e uma égua. De modo geral apresentaram sinais clínicos característicos da doença e nenhum animal era vacinado contra raiva. Sem respostas aos tratamentos, os animais vieram a óbito, e para diagnóstico, foi feita a coleta de material encefálico desses animais, obtendo todos positivos para raiva. O objetivo do trabalho foi apresentar casos epidemiológicos associado à literatura em relação à raiva.(AU)

Rabies is an important disease in herbivores, being zoonosis, of fast evolution and without effective treatment, demanding a strict prophylactic control. Positive cases for disease were reported at the FAEF veterinary hospital in the city of Garça / SP, with three cattle and one mare. In general, they presented characteristic clinical signs of the disease and no animals were vaccinated against rabies. Without response to the treatments, the animals died, and for diagnosis, the brain was collected from these animals, obtaining all positive for rabies. The objective of this study was to present epidemiological cases associated with the literature regarding rabies.(AU)

Assuntos

RESUMO

A babesiose é causada por hematozoários, como Babesia bovis e Babesia bigemna. Os sinais clínicos encontrados são febre, depressão, anorexia, icterícia, taquicardia, taquipneia, hemoglobinúria e quando há desenvolvimento da babesiose cerebral, os animais infectados por Babesia bovis demonstram sinais neurológicos. O objetivo deste trabalho é relatar caso de babesiose cerebral em bovino jovem, atendido no Hospital Veterinário da Faculdade de Ensino Superior e Formação Integral FAEF. Em neonatos esta enfermidade ocorre com baixa frequência, devido à transferência de imunidade passiva. A necropsia é de essencial importância para o diagnóstico e prevenção desta enfermidade nos animais.(AU)

Babesiosis is caused by hematozoa, such as Babesia bovis and Babesia bigemna. The clinical signs found are fever, depression, anorexia, jaundice, tachycardia, tachypnea, hemoglobinuria and when there is development of cerebral babesiosis, Babesia bovis infected animals show neurological signs. The objective of this work is to report case of cerebral babesiosis in young bovine, attended at the Veterinary Hospital of the Faculty of Higher Education and Integral Training - FAEF. In neonates this disease occurs with low frequency, due to the transference of passive immunity. Necropsy is of essential importance for the diagnosis and prevention of this disease in animals.(AU)

Assuntos