RESUMO
The clinical charts belonging to patients suffering from congenital adrenal hyperplasia secondary to a deficiency of the enzyme 21-hydroxylase seen at the Endocrinology Department during 1978 to 1988 were reviewed. The 34 patients were analyzed for various clinical and biochemical parameters when admitted and during their follow-up. The reason for their consultation, in 73.5% of the cases was due to the presence of ambiguity in their genitalia at the time of their birth. The most frequent clinical variety was the classical or "salt-loser" in 55.8% of the cases. The growth chart analysis showed that those patients who were "salt-losers" grew and were categorized in lesser percentiles than those who had the simple variety of the disease. The results are similar to those reported in worldwide literature. A close follow-up with emphasis placed on clinical and laboratory data seems to allow for adequate growth and development of these patients.
Assuntos
Hiperplasia Suprarrenal Congênita , Hiperplasia Suprarrenal Congênita/etiologia , Hiperplasia Suprarrenal Congênita/tratamento farmacológico , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , MasculinoRESUMO
Sixteen children with hGH deficiency were treated for a year with methionyl-somatotropin (Somatonorm) or recombinant-somatotropin (Genotropin). The hormone was administrated subcutaneously 3 time/week, 0.45-0.6 IU/kg/week. After a year of treatment, the mean growth rate in those who received Somatonorm increased from 3.96 +/- 0.8 cm/yr to 9.08 +/- 2.7 cm/yr, and in those who received Genotropin from 3.6 +/- 0.6 cm/yr to 8.58 +/- 1.1 cm/yr with no significant difference. No adverse effects were observed, but four children that received Somatonorm developed antihGH antibodies with a very low binding capacity, of less than 0.1 mg/L. All the children that received Genotropin were negative for antihGH antibodies.
Assuntos
Transtornos do Crescimento/tratamento farmacológico , Hormônio do Crescimento/análogos & derivados , Hormônio do Crescimento/deficiência , Hormônio do Crescimento/uso terapêutico , Adolescente , Anticorpos/sangue , Criança , Pré-Escolar , Esquema de Medicação , Feminino , Transtornos do Crescimento/etiologia , Hormônio do Crescimento/imunologia , Hormônio do Crescimento Humano , Humanos , Masculino , Proteínas Recombinantes/uso terapêuticoRESUMO
There are still great incognites in the etiology and physiopathology of the so called chronic complications of diabetes mellitus. There are specially many questions about the origin of the diabetic microangiopathy which is the cause of several alterations like the diabetic retinopathy. Genetic, immunological and environmental factors have been involucrated in its development. In order to study the genetic involvement, in fifteen normal brothers and sisters of known diabetics type I a retina fluorangiographic study was performed. In all the cases the fluorangiography was normal suggesting that the genetic factors must coexist with the metabolic disturbance to produce retina vessels damage.