1.
J Pediatr
; 101(4): 647, 1982 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7119975
2.
J Pediatr
; 100(4): 651-4, 1982 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7062220
RESUMO
Metronidazole pharmacokinetics and tissue distribution were studied in 11 infants varying in gestational age from 28 to 40 weeks. Elimination half-life was inversely related to gestational age, and ranged from 22.5 to 109 hours. Hepatic hydroxylation of metronidazole was not evident in infants less than 35 weeks' gestation, unless they had been exposed prenatally to betamethasone. A dosage schedule of 15 mg/kg intravenously as an initial single dose is proposed, and will provide adequate therapeutic levels for 48 hours in the preterm infant and for 24 hours in the term infant. Subsequently a dose of 7.5 mg/kg/12 hours is suggested for the first week of life.
Assuntos
Infecções Bacterianas/tratamento farmacológico , Doenças do Recém-Nascido/tratamento farmacológico , Metronidazol/metabolismo , Betametasona/uso terapêutico , Feminino , Idade Gestacional , Meia-Vida , Humanos , Recém-Nascido , Infusões Parenterais , Cinética , Masculino , Metronidazol/administração & dosagem , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Distribuição Tecidual
3.
J Pediatr
; 92(5): 848-9, 1978 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-641642