RESUMO
Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) (p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) (p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts.
Assuntos
Croton/química , Peroxidação de Lipídeos/efeitos dos fármacos , Condicionamento Físico Animal , Extratos Vegetais/farmacologia , Animais , Creatina Quinase , Radicais Livres/metabolismo , L-Lactato Desidrogenase/metabolismo , Masculino , Músculo Esquelético/metabolismo , Estresse Oxidativo/efeitos dos fármacos , RatosRESUMO
Introdução: o bem-estar subjetivo se refere a como as pessoas se sentem e avaliam suas vidas. Largamente insinua-se que uma pessoa com altas taxas de bem-estar subjetivo encontra-se satisfeita com a vida e possui altas taxas de afetos positivos e relativa falta de afetos negativos. Objetivo: estimar a prevalência do bem-estar subjetivo de mulheres participantes de um programa social, bem como seus fatores associados. Métodos: estudo epidemiológico, transversal e analítico, no qual a amostra contou com 321 mulheres participantes de um programa social, com idades diversas, do Polo 1 (entre os 29 estudados). As características sociodemográficas e aquelas relacionadas à saúde foram consideradas variáveis independentes, assim como o bem-estar subjetivo foi a dependente. As variáveis foram avaliadas por frequências absolutas e relativas, e a magnitude da associação entre elas foi avaliada pela Razão de Prevalência bruta e ajustada, estimada mediante o modelo de Poisson com variância robusta. Resultados: a maioria das mulheres analisadas era casada (52,4%) e com obesidade (70,3%) e bem-estar subjetivo acima da média (62,8%). As mulheres com 40 anos ou mais apresentaram maior probabilidade de deter melhores índices de bem-estar subjetivo (RP=1,32), enquanto mulheres obesas apresentaram menor probabilidade de apresentar índices satisfatórios de bem-estar subjetivo (RP=0,77). Conclusão: mulheres com idade mais elevada apresentaram maior probabilidade de melhores índices de bem-estar subjetivo, enquanto obesas apresentaram menor probabilidade de índices satisfatórios de bem-estar subjetivo.(AU)
Introduction: Subjective well-being refers to how people feel and value their lives. Very broadly it is implied that a person with high rates of subjective well-being is satisfied with life and has high rates of positive affects and relative lack of negative affects. Objective: to estimate the prevalence of the subjective well-being of practicing individuals of a physical activity program, as well as its associated factors. Methods: an epidemiological, cross-sectional and analytical study, whose sample had 321 women participating in a social program, of different ages, from Polo 1 (among the 29 studied). Sociodemographic and health-related characteristics were considered independent variables, just as subjective well-being was dependent. The variables were evaluated by absolute and relative frequencies and the magnitude of the association between them was evaluated by the gross and Adjusted Prevalence Ratio, estimated using the Poisson model with robust variance. Results: the majority of the women analyzed were married (52.4%) and obese (70.3%) and subjective well-being above average (62.8%). Women who were 40 years of age or older were more likely to have better subjective well-being (PR=1.32), whereas obese women were less likely to present satisfactory subjective well-being (PR=0.77). Conclusion: women with higher age were more likely to have better subjective well-being, while obese women were less likely to have satisfactory subjective well-being rates.(AU)