RESUMO
Peripheral joint involvement is a common, potentially debilitating feature of psoriatic arthritis (PsA). Joint involvement is commonly symmetrical and polyarticular similar to rheumatoid arthritis (RA) but it can also be oligoarticular, asymmetrical or occasionally monoarticular. Involvement of the distal interphalangeal joints is a feature which distinguishes PsA from RA. Articular involvement in PsA can be severe with a mutilating arthropathy found in about 5%. These patients are characterised clinically by digital shortening and on radiographs by erosion on both sides of the joint and/or osteolysis. Treatments targeting joint disease frequently reduces symptoms and signs resulting in prevention of damage progression.
Assuntos
Artrite Psoriásica/diagnóstico , Articulações/patologia , Artrite Psoriásica/epidemiologia , Artrite Psoriásica/patologia , Artrite Psoriásica/terapia , Artrografia , Progressão da Doença , Humanos , Valor Preditivo dos Testes , Prognóstico , Índice de Gravidade de Doença , Membrana Sinovial/patologiaRESUMO
This paper records for the first time the exocrine pancreatic response to scorpion venom, in this case that of Tityus trinitatia, a scorpion endemic in Trinidad. The crude venom injected intravenously into fasting anaethetised dogs induced a secretion of the exocrine pancreas. The secretion evoked was rich in enzyme (AU)
Assuntos
Cães , 21003 , Escorpiões , Pâncreas/efeitos dos fármacos , Pâncreas/enzimologia , Suco Pancreático/enzimologia , Suco Pancreático/metabolismo , Peçonhas , Amilases/metabolismo , Lipase/metabolismo , Tripsina/metabolismo , Trinidad e TobagoAssuntos
21003 , Feminino , Ratos , Técnicas In Vitro , Pâncreas/efeitos dos fármacos , Escorpiões , Peçonhas , Amilases/metabolismo , Pâncreas/metabolismoRESUMO
This study examined the action of the venom of the scorpion Tityus trinitatis on the pancreas and gastrointestinal tract in anaesthetized dogs, on the isolated extracorporeal haemoperfused canine pancreas and on the isolated canine sphincter of Oddi. The venom induces exocrine secretion in both the isoslated and intact pancreas and causes contraction of the isolated sphincter of Oddi. These results are discussed in relation to the pathogenesis of acute scorpion pancreatitis and possibly of some other forms of acute pancreatitis. (Summary)
Assuntos
21003 , Cães , Humanos , Pancreatite/etiologia , Peçonhas/toxicidade , Doença Aguda , Amilases/sangue , /efeitos dos fármacos , Esfíncter da Ampola Hepatopancreática/efeitos dos fármacos , Pâncreas/metabolismo , Ductos Pancreáticos/efeitos dos fármacos , Secretina/administração & dosagem , Trinidad e TobagoRESUMO
Acute pancretitis following the sting of the scorpion of Trinidad, Tityus trinitatis has been described (Waterman, 1938; Poon-King, 1963;Bartholomew, 1970). Whereas excessive salivary secretion is well documented as one of the common sequelae of scorpion stings, as far as we are aware no reports have ever been published on the secretory response of the pancreas to scorpion venom. This paper records for the first time the pancreatic exocrine response to scorpion venom, in this case that of T. trinitatis from Trinidad. (AU)