RESUMO
An anomalous high frequency of ATL was observed in a remote 'noir maroons' village of French Guiana. Since it is not clear if HTLV-I is responsible for different frequencies of disease in different geographical areas, we undertook a comparison of the population with a similar one located in Gabon. We found a much higher degree of gp46 surface envelope glycoprotein sequence conservation in the Guianese village than in the Gabonese one.
Assuntos
Variação Genética , Vírus Linfotrópico T Tipo 1 Humano/genética , Leucemia-Linfoma de Células T do Adulto/virologia , Sequência de Bases , Sequência Conservada , DNA Viral , Feminino , Guiana Francesa/epidemiologia , Gabão/epidemiologia , Produtos do Gene env/genética , Humanos , Leucemia-Linfoma de Células T do Adulto/epidemiologia , Masculino , Dados de Sequência Molecular , Filogenia , Proteínas Oncogênicas de Retroviridae/genética , Alinhamento de SequênciaRESUMO
300 samples of serum (in seven age-groups) from the "creole" population of french Guiana were tested for antibodies to the four human herpesviruses (HSV, VZV, CMV and EBV). Results show the higher prevalence of CMV and EBV in early childhood, HSV primary infection appears to take place earlier in life than in temperate and developed countries, but later than in other tropical countries. The pattern of VZV epidemiology in french Guiana is consistent with what is known in tropical countries: varicella is also a disease of adolescents and young adults. CMV appears to be more prevalent in women than in men between 21 and 40.