RESUMO
Monoclonal gammopathy of undetermined significance (MGUS) is frequently diagnosed in the elderly population. Most physicians will have to evaluate and manage patients with this condition. Recent studies have clarified risk factors, natural history, prognosis and complications of this common condition. This short review discusses basic concepts and recent developments that will facilitate the diagnosis and management of this condition by primary care physicians and specialists in other areas of medicine.
Assuntos
Gamopatia Monoclonal de Significância Indeterminada , Amiloidose/epidemiologia , Progressão da Doença , Neoplasias Hematológicas/epidemiologia , Humanos , Incidência , Programas de Rastreamento , Gamopatia Monoclonal de Significância Indeterminada/diagnóstico , Gamopatia Monoclonal de Significância Indeterminada/epidemiologia , Gamopatia Monoclonal de Significância Indeterminada/patologia , Gamopatia Monoclonal de Significância Indeterminada/terapia , Osteoporose/etiologia , Paraproteínas/análise , Doenças do Sistema Nervoso Periférico/etiologia , Prognóstico , Risco , Fatores de Risco , Macroglobulinemia de Waldenstrom/epidemiologiaRESUMO
The incidence of infections is increased in patients with cancer and certain hematologic disorders. We retrospectively reviewed all the patients evaluated for infection in our HYematology-Oncology unit during a six month period. The purpose of this study was to identify the most common organisms causing infection, evaluate the usefulness of tests performed as well as to determine the outcome and complications of therapy. Contrary to earlier experience the most common organisms causing bacteremia were gram-positive. Despite this finding, gram-negative organisms remained important pathogens specially of the respiratory and urine tract judging by their predominance in urine and sputum cultures. Of the commonly ordered tests, the chest X-ray was the most frequently positive test for infection and the complication rate of antibiotic therapy was 15%. We conclude that in addition to the traditional antibiotics effective against gram-negative organisms, institution of antibiotics effectve against gram-positive organisms including Staphylococcus epidermides, should be considered early in the management of these patients