RESUMO
AIM: To investigate the plasma concentrations of glucose, insulin and tumour necrosis factor-α (TNF-α) of rats with maternal apical periodontitis (AP) and to explore the effect of maternal inflammation on the initial steps of insulin signalling and the inflammatory pathway in the gastrocnemius muscle (GM) and periepididymal white adipose tissue (pWAT) of adult offspring. METHODOLOGY: Fifteen female Wistar rats were distributed into a control group (CN), a group with 1 tooth with AP (1AP) and a group with 4 teeth with AP (4AP). Thirty days following induction of AP, female rats from all groups were mated with healthy male rats. When male offspring reached 75 days of age, plasma concentrations of glucose, insulin and TNF-α were quantified. Insulin resistance was evaluated by the homoeostasis model assessment of insulin resistance (HOMA-IR) index. Phosphorylation status of pp185 tyrosine, insulin receptor substrate 1 (IRS-1) serine, IκB kinase α/ß (IKKα/ß) and c-Jun N-terminal kinase (JNK) in the GM and pWAT were measured by Western blot. Analysis of variance was performed, followed by the Tukey's post hoc test. P values <0.05 were considered to be statistically significant. RESULTS: Maternal AP promoted insulin resistance, impaired the initial steps of insulin signalling, significantly increased plasma concentrations of insulin (P < 0.001) and TNF-α (P < 0.05), and enhanced IKKα/ß phosphorylation in the GM and pWAT (P < 0.05) of adult offspring. However, maternal AP did not affect fasting glycaemia and JNK phosphorylation in the GM and pWAT of adult offspring. CONCLUSIONS: Maternal AP was associated with insulin resistance in adult offspring through alterations in insulin signalling and inflammation pathways. The study provides information on the impact of maternal AP on the development of metabolic alterations such as insulin resistance in adult offspring and reinforces the importance of preventing maternal AP in order to maintain the general health of offspring.
Assuntos
Resistência à Insulina , Periodontite Periapical , Filhos Adultos , Animais , Glicemia , Feminino , Humanos , Masculino , Ratos , Ratos Wistar , Fator de Necrose Tumoral alfaRESUMO
AIM: Dental health professionals, including dental students, are at high risk of exposure to infection with the hepatitis C virus (HCV) through occupational percutaneous injuries and eye exposure. Further, fear of HCV infection is associated with discriminatory attitudes. The current study aimed to evaluate the knowledge about HCV infection amongst dental students and their attitudes towards patients infected with HCV. METHODS: A cross-sectional survey was conducted amongst 340 Brazilian dental students from two public universities using an instrument containing information regarding demographic characteristics, knowledge of HCV and attitudes towards patients with HCV infection. Descriptive statistics, Fisher's exact test, Student's t-tests, Mann-Whitney U-test and multiple logistic regression (MLR) were carried out (P < 0.05 was considered significant). RESULTS: Response rate was 90% (n = 306), and more than half (54%, n = 165) of participants had high knowledge level (above the mean); 97.7% (n = 299) demonstrated positive attitudes. MLR showed that high knowledge of dental students regarding HCV was substantially influenced by advancement in year of study (last year; P < 0.001) and type of university (federal; P = 0.049). Positive attitude towards HCV-infected patients was mainly influenced by age (P = 0.004) and male gender (P = 0.022). CONCLUSIONS: These results demonstrated a satisfactory knowledge about HCV infection amongst dental students, but some gaps were observed, suggesting the importance of continuous education about HCV in this population to prevent HCV infection as well as discrimination and prejudice towards patients with hepatitis C.
Assuntos
Atitude Frente a Saúde , Comportamento , Conhecimentos, Atitudes e Prática em Saúde , Hepatite C , Estudantes de Odontologia/psicologia , Adolescente , Adulto , Brasil , Estudos Transversais , Feminino , Humanos , Masculino , Autorrelato , Adulto JovemRESUMO
BACKGROUND: Knowing the intention of mothers is important to plan actions to improve exclusive breastfeeding rates. AIM: The objective of this retrospective study was to verify the intention to breastfeed and the intended breastfeeding duration of a group of women participating in a public prenatal dental care program in the city of Araçatuba, Brazil. METHODS: The records of 933 childbearing women were analyzed and their intention to breastfeed and intended breastfeeding duration were associated to women's age, ethnicity, marital status, education, employment, number of gestations, previous breastfeeding experience, previous breastfeeding guidance, presence of complications during pregnancy, and systemic diseases. Data were inserted into Epi Info 2000 and analyzed with Biostat, at a 5% level of significance, and confidence interval of 95%. FINDINGS: Participants mean age was 26.1±5.9years. The majority of women (96.5%) declared their intention to breastfeed their babies. The main variables to affect the intention to breastfeed were the number of gestations (p=0.001), previous breastfeeding experience (p=0.03), and previous breastfeeding guidance (p=0.01). Intended breastfeeding duration was significantly affected by women's age (p=0.04), employment (0.02), the number of gestations (p=0.001), and previous breastfeeding experience (p=0.04). CONCLUSIONS: Previous positive breastfeeding experience and guidance during prenatal examinations positively affected women's intention to breastfeed; while older, unemployed women in their second or more gestation and previous breastfeeding experience intended to breastfeed their children for longer periods of time.
Assuntos
Aleitamento Materno/psicologia , Mães/psicologia , Adulto , Fatores Etários , Brasil , Feminino , Humanos , Gravidez , Estudos Retrospectivos , Fatores Socioeconômicos , Adulto JovemRESUMO
Facial asymmetry is a common human characteristic and can occur on many levels, originate of genetic factors, and can be caused by traumas or due to cross bite and/or muscular disability. The aim of this study was to evaluate the relation between posterior crossbite, median line deviation and facial asymmetry. For this study 70 children aged between 3 and 10 years-old were examined and photographed. Using Microsoft Office Power Point 2007, horizontal lines and one vertical line on median line were drawn, to subjectively analyze facial discrepancies. In relation to overjet, the majority of children (78.6%) showed normal relation, followed by high overjet (17.1%), anterior crossbite (4.3%). In relation to overbite, the majority of children (60%) showed normal relation, 27.1% anterior opened bite (negative overbite), and 12.9% showed high overbite. Posterior crossbite was present in 27.1% of children. Among them, 68.4% showed unilateral crossbite on right side, 21.1% bilateral crossbite and 10.5% unilateral crossbite on left side. The relation between posterior crossbite and facial asymmetry, according to Fisher´s Exact Test (p=0.0970), there was no statistically significant association. In relation to median line, the association was statistically significant with posterior crossbite (p=0.0109) and with facial asymmetry (p=0.0310). There was association between posterior crossbite and median line deviation. There was no association between posterior crossbite and facial asymmetry
La asimetría facial es una característica humana común que puede ocurrir en diferentes niveles, originarse por factores genéticos, ser causada por traumas o mordida cruzada como resultado o discapacidad muscular. El objetivo de este estudio fue evaluar la relación entre la mordida cruzada posterior, desviación de la línea mediana y asimetría facial. Fueron evaluados 70 niños entre 3 y 10 años de edad mediante examen clínico y fotográfico. Utilizando Microsoft Power Point Office 2007, se dibujaron líneas horizontales y una línea vertical en la línea mediana, para analizar subjetivamente las diferencias faciales. En relación con el resalte, la mayoría de los niños (78,6%) mostró relación normal, seguido por un resalte aumentado (17,1%) y mordida cruzada anterior (4,3%). En relación con la sobremordida, la mayoría de los niños (60%) mostró relación normal, 27,1% una mordida abierta anterior (sobremordida negativa) y 12,9% mostró una sobremordida aumentada. La mordida cruzada posterior estuvo presente en 27,1% de los niños. Entre ellos, el 68,4% presentaba mordida cruzada unilateral del lado derecho, 21,1% mordida cruzada bilateral y el 10,5% mordida cruzada unilateral en el lado izquierdo. No hubo asociación estadísticamente significativa entre la mordida cruzada posterior y asimetría facial según la prueba exacta de Fisher (p=0,0970). En relación a la línea mediana, se observo una asociación estadísticamente significativa entre mordida cruzada posterior (p = 0,0109) y asimetría facial (p=0,0310). Existe asociación entre la mordida cruzada posterior y la desviación de línea mediana. No hubo asociación entre la mordida cruzada posterior y asimetría facial
Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Assimetria Facial , Má Oclusão/fisiopatologia , Sobremordida/fisiopatologiaRESUMO
OBJECTIVES: The objective of this study was to estimate the prevalence of deciduous tooth erosion and to identify possible associations with sex, age and toothbrushing frequency in children aged 4-6 years. METHODS: The sample was drawn from attendants (n = 7058) of 57 public preschools in a Brazilian city. Tooth wear index was used to evaluate erosion. Descriptive statistical analysis consisted of the calculation of the prevalence of dental erosion; chi-squared and Fisher's exact tests were performed to verify the association between dental erosion and sex, age and toothbrushing frequency. RESULTS: Two thousand and seven hundred and fifty-nine preschool students were examined. Deciduous tooth erosion was observed in 0.6% of children and its incidence did not differ between sexes. The highest prevalence was observed in children aged 6 years (58.3%) and the most affected sextants were the fourth (22.86%) and sixth (20.00%), indicating that lingual and occlusal tooth surfaces were most frequently involved. The degree of involvement was classified as incipient in 54.29% of children and moderate in 45.71%. The significance level was set at 5%. No association was found between erosion and sex, age or toothbrushing frequency. CONCLUSIONS: The prevalence of deciduous tooth erosion was low in Brazilian children, and this disorder is not considered a public health problem in this part of the population.
Assuntos
Erosão Dentária/epidemiologia , Dente Decíduo , Distribuição por Idade , Brasil/epidemiologia , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Masculino , Prevalência , Distribuição por Sexo , Escovação Dentária/estatística & dados numéricosRESUMO
Evaluar la asociación entre hábitos de succión no nutritivos y la práctica del amamantamiento materno. Material y Métodos: Fueron realizadas entrevistas con 87 embarazadas y visitas mensualmente hasta los 6 meses de edad de los bebes, abordando preguntas sobre condiciones socio económica-culturales, práctica de amamantamiento y hábitos. Resultados: Casi la totalidad (94,7%) de las madres empezó a amamantar a los bebes en el primer mes, pero apenas el 49,7% amamantaban exclusivamente del seno. Al fin del sexto mes ninguna madre estaba amamantando exclusivamente y un 50% de los niños habían sido destetados. Los hábitos y uso de chupete fueron asociados significantemente con niños amamantados bajo amamantamiento exclusivo (p=0,0065 y 0,0270 respectivamente) y las amamantadas en el seno (los dos p<0,0001). La tasa de destete precoz fue elevada y baja la prevalencia de amamantamiento materno exclusivo, demostrando asociación entre hábitos y uso de chupete con amamantamiento materno
Verifying the association with non-nutritives suction habits and practice of breastfeeding. Material and Methods: 87 pregnants were interviewed and were monthly home visits until 6 mounths old babies, the studied variables were: social-economic-culture conditions, breast feeding pratical and non-nutritives suction habits. Results: 94.7% for mothers started breastfeeding their babies in the first month, but only 49.7% exclusively children breastfeeding. The sixth month nobody mother non-exclusively breastfed ones and 50% were weaning. The habits and pacifier users were significant association with exclusively children breastfed (p=0.0065 and 0.0270 respectively) and children breastfed (both p<0.0001). The early weaning rate was high and low rate of exclusive breastfeeding, existing association between non-nutritives suction habits and pacifier users with breastfeeding
Assuntos
Humanos , Masculino , Feminino , Comportamento Alimentar , Aleitamento Materno , Desmame , OdontologiaRESUMO
AIM: To examine how much final-year undergraduate dental students know about postural dental ergonomic requirements, and how well they apply these requirements clinically. BACKGROUND: Dentists are vulnerable to diverse mechanical (e.g. postural) and non-mechanical occupational risks. MATERIALS AND METHODS: Eight postural requirements found in normalising documents were identified, reproduced, photographed, and analysed to develop a test of visual perception (TVP). Photographs of the 69 participating students were taken during their clinical care to ascertain ergonomics compliance, after which the students were administered the TVP. Pearson's test was used to correlate the level of knowledge (TVP) and its clinical application (photographic analysis) among the 552 observations made for each test (total of 1104 observations). RESULTS: 65.7% of the TVP questions were answered correctly and 35% of the photographic cases were in compliance with ergonomic requirements (+ 0.67, P < 0.0001). CONCLUSION: The knowledge of ergonomics postural requirements and their clinical application among the dental students surveyed were not satisfactory. The reasons for the learning difficulties encountered by the students should be identified to improve the learning process. The didactic use of digital images in this study may help in this endeavour.
Assuntos
Ergonomia , Conhecimentos, Atitudes e Prática em Saúde , Doenças Profissionais/prevenção & controle , Postura , Estudantes de Odontologia/psicologia , Feminino , Humanos , Masculino , Fotografação , Projetos Piloto , Inquéritos e Questionários , Percepção VisualRESUMO
AIM: To compare stress distribution between a fractured maxillary central incisor restored with direct composite resin only (CR) or associated with different post materials, using finite element analysis. METHODOLOGY: A three-dimensional model of a sound maxillary central incisor and supporting structures was constructed, using data from the dental literature. Changes were made in the crown region to create a tooth with a restored crown fracture. A composite resin restoration only and restorations associated with different tapered post systems (glass fibre, carbon fibre, titanium and zirconia ceramic) were also evaluated, resulting in six experimental models. A static chewing pressure of 2.16Nmm(-2) was applied to two areas of the palatal surface of the tooth. Stress distribution was analysed under a general condition and in the structures of the models separately. RESULTS: The maximum stresses were concentrated as follows: at the cemento-enamel junction in the model with a sound maxillary central incisor, restored with CR and with a composite resin restoration associated with fibre posts; in the enamel at the post-enamel interface on the palatal surface of the model with a titanium post; and in the post of the model with zirconia ceramic post. CONCLUSIONS: None of the restorations evaluated was able to recover the stress distribution of the sound tooth. The models restored with composite resin associated with a glass or carbon fibre post had similar stress distributions to that of the model restored with CR. The different post materials were shown to have a substantial influence on stress distribution, with less stress concentration when fibre posts were used.
Assuntos
Resinas Compostas/uso terapêutico , Restauração Dentária Permanente/métodos , Incisivo/lesões , Técnica para Retentor Intrarradicular/instrumentação , Fraturas dos Dentes/terapia , Fenômenos Biomecânicos , Carbono , Fibra de Carbono , Porcelana Dentária , Planejamento de Prótese Dentária , Falha de Restauração Dentária , Análise do Estresse Dentário , Análise de Elementos Finitos , Vidro , Humanos , Maxila , Titânio , Dente não Vital , ZircônioRESUMO
The toothbrush is an effective instrument for oral diseases prevention. The flexibility and status of bristles, as well as the size of the handle are fundamental for an effective toothbrushing. Thus, the assessment of physical characteristics of toothbrushes is important. This study evaluated the deterioration and wear of bristles of toothbrushes used by preschool children. For the sample selection, five elementary schools were assorted from a city of the São Paulo State northwest region, one from each city area. All toothbrushes used by preschool children who aged between 5 and 6 years old and who attended the assorted schools were visually analysed by two calibrated examiners, according to the criteria proposed by Rawls HR, Mkwayi-Tulloch NJ, Casella R, Cosgrove R (J Dent Res 1989; 12:1781): 0 - it is impossible to state if the toothbrush was used or not; 1 - the bristles seem to be separated within some tufts; 2 - most tufts are separated, many cover other tufts and present a large number of curved and inclined bristles; 3 - most tufts are covered by others and bristles are folded and tipped. In total, 333 toothbrushes were evaluated. The data obtained revealed that 57.96% of the toothbrushes presented adequate condition for utilization (scores 0 and 1), whereas 42.04% presented inadequate bristles for their function (scores 2 and 3). It was concluded that a great number of toothbrushes presented deterioration of the bristles. Thus, there is the need to guide and promote awareness among teachers, parents and children as well as the need to replace toothbrushes.
Assuntos
Dispositivos para o Cuidado Bucal Domiciliar/classificação , Higiene Bucal/instrumentação , Escovação Dentária/instrumentação , Criança , Pré-Escolar , Falha de Equipamento , HumanosRESUMO
The current study evaluated the influence of two endodontic post systems and the elastic modulus and film thickness of resin cement on stress distribution in a maxillary central incisor (MCI) restored with direct resin composite using finite element analysis (FEA). A three-dimensional model of an MCI with a coronary fracture and supporting structures was performed. A static chewing pressure of 2.16 N/mm2 was applied to two areas on the palatal surface of the composite restoration. Zirconia ceramic (ZC) and glass fiber (GF) posts were considered. The stress distribution was analyzed in the post, dentin and cement layer when ZC and GF posts were fixed to the root canals using resin cements of different elastic moduli (7.0 and 18.6 GPa) and different layer thicknesses (70 and 200 microm). The different post materials presented a significant influence on stress distribution with lesser stress concentration when using the GF post. The higher elastic modulus cement created higher stress levels within itself. The cement thicknesses did not present significant changes.