RESUMO

Tuberculosis in seals is caused by Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray-based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii: PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised.

Assuntos

Marcadores Genéticos , Genoma Bacteriano , Mycobacterium/genética , Otárias/microbiologia , Variação Genética , Mycobacterium/isolamento & purificação , Análise de Sequência com Séries de Oligonucleotídeos , Especificidade da Espécie