RESUMO
Interleukin-1 receptor antagonist (IL-1ra) gene polymorphisms in 83 human immunodeficiency virus (HIV)-seropositive women were evaluated. Fourteen of the subjects (16.9%) were homozygous for IL-1ra allele 2 (IL-1RN*2). These women had a lower median level of HIV RNA than did women homozygous for allele 1 (IL-1RN*1) (P = 0.01) or heterozygous for both alleles (P = 0.04). Among 46 subjects not receiving antiretroviral treatment, HIV levels were also reduced in IL-1RN*2 homozygous individuals (P < 0.05). There was no relation between IL-1ra alleles and CD4 levels.
Assuntos
Soropositividade para HIV/genética , HIV-1/isolamento & purificação , Polimorfismo Genético , RNA Viral/sangue , Sialoglicoproteínas/genética , Feminino , Genótipo , Soropositividade para HIV/virologia , Humanos , Proteína Antagonista do Receptor de Interleucina 1RESUMO
A 14-year-old boy had inguinal lymphadenitis and associated urinary retention; herpetic genital and anal lesions were absent. Lymph node biopsy established the presence of infection with herpes simplex virus type 2. We recommend that this infection be considered in the differential diagnosis of adolescent patients with urinary retention and constipation, even when the diagnostic clue provided by genital ulcers is absent.
Assuntos
Infecções por Herpesviridae/complicações , Infecções por Herpesviridae/virologia , Herpesvirus Humano 2/isolamento & purificação , Retenção Urinária/complicações , Adolescente , Constipação Intestinal/complicações , Humanos , Linfadenite/complicações , MasculinoRESUMO
Diplophonia has never been described in a neonate. An unusual case, then, of diplophonia in a neonate is described here. There is a description of the acoustic characteristics of this infant's cry and a discussion of their significance. This contributes to a review of the differential diagnosis of diplophonia. Moreover, this case further shows the essential relation between laryngoscopic findings and acoustical data.