RESUMO

Two brothers with progressive familial intrahepatic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.

Assuntos

Colestase/tratamento farmacológico , Fenobarbital/uso terapêutico , Ácidos e Sais Biliares/sangue , Cálcio/sangue , Pré-Escolar , Colestase/sangue , Colestase/genética , Humanos , Testes de Função Hepática , Masculino , Fenobarbital/administração & dosagem , Fatores de Tempo