RESUMO
Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres to show that only 3/82 (3.7 percent) have antibody to HHV-8, demonstrating that there is little, if any, cross-relativity between antibodies to these two gamma viruses. (AU)
Assuntos
Adulto , Idoso , Humanos , Masculino , Feminino , Adolescente , Estudo Comparativo , Criança , Pessoa de Meia-Idade , Infecções por Herpesviridae/epidemiologia , Herpesvirus Humano 8/imunologia , Sarcoma de Kaposi/epidemiologia , África/epidemiologia , Idoso de 80 Anos ou mais , Linfoma de Burkitt/epidemiologia , Região do Caribe/epidemiologia , Neoplasias Nasofaríngeas/epidemiologia , Estudos Soroepidemiológicos , Estados Unidos/epidemiologiaRESUMO
Data have been collected from 602 Caucasians, 190 Afro-Caribbeans and 257 Asians of Indo/Pakistani descent who have been profiled using a new six locus short tandem repeat (STR) multiplex. The data have been analysed by conventional significance testing methods: the exact test, homozygosity, and conventional goodness of fit to Hardy-Weinberg proportions. Frequency tables are given and the expected performance in British forensic casework is discussed.(AU)
Assuntos
Estudo Comparativo , Humanos , Etnicidade/genética , Marcadores Genéticos/genética , Sequências Repetitivas de Ácido Nucleico/genética , Homozigoto , Modelos Genéticos , Probabilidade , Mapeamento Cromossômico , Frequência do Gene , Genética Populacional , Genótipo , Triagem de Portadores GenéticosRESUMO
Populations of white Caucasians, Afro-Caribbeans and Asians residing within the UK have been analysed at 4 different hypervariable loci. A computerised system was used to store and to analysed the data. Simulation experiments were carried out in order to determine whether there was any evidence for population stratification, which would lead to non-independence of allelic distributions. (AU)