RESUMO
PURPOSE: Maternal and Child Health and Nutrition in Acre, Brazil (MINA-Brazil) is a longitudinal, prospective population-based birth cohort, set-up to understand the effects of early environmental exposures and maternal lifestyle choices on growth and development of the Amazonian children. PARTICIPANTS: Mother-baby pairs (n=1246) were enrolled at delivery from July 2015 to June 2016 in Cruzeiro do Sul, Acre, Brazil. Mothers of 43.7% of the cohort were recruited in the study during pregnancy from February 2015 to January 2016. Study visits took place during pregnancy, delivery, at 1 month, 6 months, 1 year and 2 years after delivery. In addition to clinical and epidemiological data, samples collected by the MINA-Brazil study include plasma, serum and extracted DNA from blood and faeces, which are stored in a biobank. FINDINGS TO DATE: Key baseline reports found a high prevalence of gestational night blindness (11.5%; 95% CI 9.97% to 13.25%) and maternal anaemia (39.4%; 95% CI 36.84% to 41.95%) at delivery. Antenatal malaria episodes (74.6% of Plasmodium vivax) were diagnosed in 8.0% of the women and were associated with an average reduction in birth weight z-scores of 0.35 (95% CI 0.14 to 0.57) and in birth length z-scores of 0.31 (95% CI 0.08 to 0.54), compared with malaria-free pregnancies. At 2-year follow-up, data collection strategies combined telephone calls, WhatsApp, social media community and home visits to minimise losses of follow-up (retention rate of 79.5%). FUTURE PLANS: A 5-year follow-up visit is planned in 2021 with similar interviews and biospecimens collection. The findings from this prospective cohort will provide novel insights into the roles of prenatal and postnatal factors in determining early childhood development in an Amazonian population.
Assuntos
Desenvolvimento Infantil , Saúde da Criança , Fenômenos Fisiológicos da Nutrição Infantil , Brasil/epidemiologia , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Gravidez , Estudos ProspectivosRESUMO
Early life feeding practices can directly affect the growth, development, and survival of a child. This study aimed to estimate the frequency of and factors associated with exclusive breastfeeding (EBF) in the first month of life among Amazonian infants. We used data of 1,523 mother-child pairs of the MINA-Brazil birth cohort study. Mothers were interviewed soon after delivery at baseline and by telephone at 30-45 days postpartum (n = 962, 63.2% of those eligible). Kaplan-Meier survival analysis and accelerated failure-time (AFT) models were used to estimate the probability of EBF and the factors associated with EBF duration in the first month. At 30 days of age, 36.7% of the studied population (95% confidence interval [CI] 33.6-39.8) were exclusively breastfed, with a median duration of 16 days. Considering all eligible children for follow-up, the probability of EBF in the first month was 43.7% (95% CI 40.4-46.8), and the median duration was 30 days. The duration of EBF (time-ratio, TR) was 28% longer among multiparous mothers (TR 1.28; 95% CI 1.11-1.48). The use of a pacifier and the occurrence of wheezing were associated with a reduced EBF duration by 33% (TR 0.67; 95% CI 0.58-0.77) and 19% (TR 0.80; 95% CI 0.70-0.93), respectively. These results highlight that EBF among children in the Brazilian Amazon is considerably below international recommendations, and indicate the immediate need to plan and implement actions to promote and support breastfeeding early in life.
Assuntos
Aleitamento Materno , Desenvolvimento Infantil , Adolescente , Adulto , Brasil/epidemiologia , Análise Fatorial , Feminino , Humanos , Lactente , Recém-Nascido , Estimativa de Kaplan-Meier , Masculino , Mães , Inquéritos Nutricionais , Vigilância em Saúde Pública , Fatores de Risco , Fatores de Tempo , Adulto JovemRESUMO
Investigation of the determinants of metabolic outcomes associated with non-communicable diseases is increasingly important in developing countries, but such parameters have not been explored extensively during childhood. The present study assessed the impact of weight gain, measured as BMI-for-age Z-scores, on glucose and insulin concentrations, homeostasis model assessment index of insulin resistance (HOMA-IR) values, and systolic and diastolic blood pressure during school years among Amazonian children. A population-based prospective study of 696 children aged >4 to ≤ 10 years with complete anthropometric information at baseline (51% females and 86% of mixed race) was carried out; 411 children had data on metabolic parameters after a median follow-up period of 2.0 years (range 1.7-2.6 years). During follow-up, there was a significant increase in the proportion of overweight children (BMI-for-age Z-score >1) from 10.1 to 15.8% (P= 0.003). In linear regression models adjusted for the child's sex, age, race/ethnicity, baseline household wealth, birth weight and pubertal development stage, for each unit of BMI-for-age Z-score variation during follow-up, an increase of 8.58 (95% CI 7.68, 9.60) pmol/l in fasting plasma insulin concentrations and 1.47 (95% CI 1.30, 1.66) in HOMA-IR values was observed. There was no significant impact of weight gain on glucose concentrations and systolic and diastolic blood pressure. In conclusion, we found evidence that an increase in BMI during a 2-year period affected insulin resistance during school years. Considering the significant increase in overweight in this age group, special attention should be paid to monitoring increases in BMI in children from the Brazilian Amazon.
Assuntos
Índice de Massa Corporal , Resistência à Insulina , Glicemia/metabolismo , Pressão Sanguínea , Brasil , Criança , Pré-Escolar , Feminino , Humanos , Insulina/sangue , Modelos Lineares , Estudos Longitudinais , Masculino , Sobrepeso/sangue , Sobrepeso/fisiopatologia , Estudos Prospectivos , Aumento de PesoRESUMO
OBJECTIVE: The aim of this study was to investigate the association between the consumption of processed meat with overall, abdominal, and overall with abdominal obesity in a Japanese-Brazilian population, which is known to be at cardiometabolic risk. SUBJECTS AND METHODS: A total of 329 men and 443 women aged ≥ 30 years were evaluated in a cross-sectional population-based survey. Diagnosis of overall obesity and abdominal obesity were based on the World Health Organization (WHO) criteria for Asians. Food intake was assessed by a validated food frequency questionaire. RESULTS: In men, processed meat intake was positively associated with overall with abdominal obesity (OR 2.97; 95%CI 1.13-7.78) after adjustment. In women, only the red meat group was associated with overall with abdominal obesity after adjustment (OR 0.47, 95%CI 0.23-0.96). CONCLUSION: Our results showed that high intakes of processed meats were associated with overall with abdominal obesity in male Japanese-Brazilians, but not in females.
Assuntos
Gorduras na Dieta/efeitos adversos , Produtos da Carne/efeitos adversos , Carne/efeitos adversos , Obesidade/etiologia , Adulto , Povo Asiático , Índice de Massa Corporal , Brasil/epidemiologia , Proteína C-Reativa/metabolismo , Estudos Transversais , Comportamento Alimentar , Feminino , Humanos , Japão/etnologia , Lipídeos/efeitos adversos , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Obesidade Abdominal/etiologia , Vigilância da População , Distribuição por Sexo , Inquéritos e Questionários , Relação Cintura-QuadrilRESUMO
OBJETIVO: Investigar a associação entre consumo de alimentos embutidos e obesidade generalizada, abdominal e generalizada com abdominal em nipo-brasileiros de Bauru, SP. SUJEITOS E MÉTODOS: Quatrocentos e quarenta e três mulheres e 329 homens nipo-brasileiros não miscigenados (≥ 30 anos) foram avaliados em estudo transversal de base populacional. Para o diagnóstico de obesidade, foram empregados os critérios da Organização Mundial da Saúde para asiáticos. A ingestão de alimentos foi avaliada por meio de questionário de frequência alimentar validado. A ingestão foi estratificada em terços para análise. RESULTADOS: Nos homens, a ingestão de colesterol e alimentos embutidos mostrou-se positivamente associada à obesidade generalizada com abdominal quando o primeiro terço de ingestão foi comparado ao último, após ajustes (OR 2,97; IC95% 1,13-7,78). Em mulheres, somente o grupo das carnes vermelhas associou-se à obesidade geral com abdominal após ajustes (OR 0,47; IC95% 0,23-0,96). CONCLUSÃO: Ingestão elevada de alimentos embutidos associou-se à obesidade generalizada com adiposidade abdominal em homens nipo-brasileiros, mas não em mulheres.
OBJECTIVE: The aim of this study was to investigate the association between the consumption of processed meat with overall, abdominal, and overall with abdominal obesity in a Japanese-Brazilian population, which is known to be at cardiometabolic risk. SUBJECTS AND METHODS: A total of 329 men and 443 women aged ≥ 30 years were evaluated in a cross-sectional population-based survey. Diagnosis of overall obesity and abdominal obesity were based on the World Health Organization (WHO) criteria for Asians. Food intake was assessed by a validated food frequency questionaire. RESULTS: In men, processed meat intake was positively associated with overall with abdominal obesity (OR 2.97; 95%CI 1.13-7.78) after adjustment. In women, only the red meat group was associated with overall with abdominal obesity after adjustment (OR 0.47, 95%CI 0.23-0.96). CONCLUSION: Our results showed that high intakes of processed meats were associated with overall with abdominal obesity in male Japanese-Brazilians, but not in females.
Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Gorduras na Dieta/efeitos adversos , Produtos da Carne/efeitos adversos , Carne/efeitos adversos , Obesidade/etiologia , Povo Asiático , Índice de Massa Corporal , Brasil/epidemiologia , Proteína C-Reativa/metabolismo , Estudos Transversais , Comportamento Alimentar , Japão/etnologia , Lipídeos/efeitos adversos , Lipídeos/sangue , Obesidade Abdominal/etiologia , Obesidade/epidemiologia , Vigilância da População , Distribuição por Sexo , Inquéritos e Questionários , Relação Cintura-QuadrilRESUMO
OBJECTIVE: To assess the effect of a health promotion program on cardiometabolic risk profile in Japanese-Brazilians. METHODS: A total of 466 subjects from a study on diabetes prevalence conducted in the city of Bauru, southeastern Brazil, in 2000 completed a 1-year intervention program (2005-2006) based on healthy diet counseling and physical activity. Changes in blood pressure and metabolic parameters in the 2005-2006 period were compared with annual changes in these same variables in the 2000-2005 period. RESULTS: During the intervention, there were greater annual reductions in mean (SD) waist circumference [-0.5(3.8) vs. 1.2(1.2) cm per year, p<0.001], systolic blood pressure [-4.6(17.9) vs. 1.8(4.3) mmHg per year, p<0.001], 2-hour plasma glucose [-1.2(2.1) vs. -0.2(0.6) mmol/L per year, p<0.001], LDL-cholesterol [-0.3(0.9) vs. -0.1(0.2) mmol/L per year, p<0.001] and Framingham coronary heart disease risk score [-0.25(3.03) vs. 0.11(0.66) per year, p=0.02] but not in triglycerides [0.2(1.6) vs. 0.1(0.42) mmol/L per year, p<0.001], and fasting insulin level [1.2(5.8) vs. -0.7(2.2) IU/mL per year, p<0.001] compared with the pre-intervention period. Significant reductions in the prevalence of impaired fasting glucose/impaired glucose tolerance and diabetes were seen during the intervention (from 58.4% to 35.4%, p<0.001; and from 30.1% to 21.7%, p= 0.004, respectively). CONCLUSIONS: A one-year community-based health promotion program brings cardiometabolic benefits in a high-risk population of Japanese-Brazilians.
OBJETIVO: Avaliar o efeito do programa de promoção de saúde no perfil de risco cardiometabólico de nipobrasileiros. MÉTODOS: Um total de 466 participantes de estudo de prevalência de diabetes em Bauru, SP, no ano de 2000 completou um programa de intervenção de um ano (2005-2006) baseado em aconselhamento sobre dieta saudável e prática de atividade física. Alterações em pressão arterial e parâmetros metabólicos entre 2005 e 2006 foram comparados com alterações anuais nessas mesmas variáveis entre 2000 e 2005. RESULTADOS: Durante a intervenção, foram observadas maiores reduções anuais médias (dp) na circunferência da cintura [-0,5(3,8) vs. 1,2(1,2) cm/ano, p < 0,001], pressão arterial sistólica [-4,6(17,9) vs. 1,8(4,3) mmHg/ano, p < 0,001], glicemia 2h pós-sobrecarga de glicose [-1,2(2,1) vs. -0,2(0,6) mmol/L/ano, p < 0,001], LDL-c [-0,3(0,9) vs. -0,1(0,2) mmol/L/ano, p < 0,001] e escore de Framingham [-0,25(3,03) vs. 0,11(0,66)/por ano, p = 0,02], mas não em triglicérides [0,2(1,6) vs. 0,1(0,42) mmol/L/ano, p < 0,001] e insulinemia de jejum [1,2(5,8) vs. -0,7(2,2) UI/mL/ano, p < 0,001], comparado com o período pré-intervenção. Ocorreram reduções significativas na prevalência de glicemia de jejum alterada e tolerância à glicose diminuída após um ano de intervenção (de 58,4% para 35,4%, p < 0,001; e de 30,1% para 21,7%, p = 0,004, respectivamente). CONCLUSÕES: O programa de intervenção de um ano em hábitos de vida traz benefícios ao perfil de risco cardiometabólico em indivíduos nipobrasileiros de alto risco.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus/prevenção & controle , Educação Alimentar e Nutricional , Promoção da Saúde , Síndrome Metabólica/etiologia , Brasil/epidemiologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etnologia , Aconselhamento , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/etnologia , Dieta , Métodos Epidemiológicos , Avaliação de Eficácia-Efetividade de Intervenções , Jejum/sangue , Japão/etnologia , Estilo de Vida , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/etnologia , Atividade Motora/fisiologia , Avaliação de Programas e Projetos de SaúdeRESUMO
OBJECTIVE: To assess the effect of a health promotion program on cardiometabolic risk profile in Japanese-Brazilians. METHODS: A total of 466 subjects from a study on diabetes prevalence conducted in the city of Bauru, southeastern Brazil, in 2000 completed a 1-year intervention program (2005-2006) based on healthy diet counseling and physical activity. Changes in blood pressure and metabolic parameters in the 2005-2006 period were compared with annual changes in these same variables in the 2000-2005 period. RESULTS: During the intervention, there were greater annual reductions in mean (SD) waist circumference [-0.5(3.8) vs. 1.2(1.2) cm per year, p<0.001], systolic blood pressure [-4.6(17.9) vs. 1.8(4.3) mmHg per year, p<0.001], 2-hour plasma glucose [-1.2(2.1) vs. -0.2(0.6) mmol/L per year, p<0.001], LDL-cholesterol [-0.3(0.9) vs. -0.1(0.2) mmol/L per year, p<0.001] and Framingham coronary heart disease risk score [-0.25(3.03) vs. 0.11(0.66) per year, p=0.02] but not in triglycerides [0.2(1.6) vs. 0.1(0.42) mmol/L per year, p<0.001], and fasting insulin level [1.2(5.8) vs. -0.7(2.2) IU/mL per year, p<0.001] compared with the pre-intervention period. Significant reductions in the prevalence of impaired fasting glucose/impaired glucose tolerance and diabetes were seen during the intervention (from 58.4% to 35.4%, p<0.001; and from 30.1% to 21.7%, p= 0.004, respectively). CONCLUSIONS: A one-year community-based health promotion program brings cardiometabolic benefits in a high-risk population of Japanese-Brazilians.
Assuntos
Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus/prevenção & controle , Promoção da Saúde , Síndrome Metabólica/etiologia , Brasil/epidemiologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etnologia , Aconselhamento , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/etnologia , Dieta , Métodos Epidemiológicos , Jejum/sangue , Feminino , Humanos , Japão/etnologia , Estilo de Vida , Masculino , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/etnologia , Pessoa de Meia-Idade , Atividade Motora/fisiologia , Avaliação de Programas e Projetos de SaúdeRESUMO
BACKGROUND: The American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI), revising the National Cholesterol Evaluation Program for Adult Treatment Panel III (NCEP ATP III), and the International Diabetes Federation (IDF) have proposed definitions of metabolic syndrome that take into account waist circumference thresholds according to ethnicity. In this study we estimated the prevalence of metabolic syndrome in a Japanese-Brazilian population using NCEP definitions for Westerners (NCEPwe) and Asians (NCEPas), and IDF for Japanese (IDF). METHODS: A total of 650 Japanese-Brazilians living in a developed Brazilian city and aged 30-88 years were included. RESULTS: Metabolic syndrome prevalence according to NCEPwe, NCEPas, and IDF was, respectively, 46.5%, 56.5%, and 48.3%. Only 43.5% of subjects did not have metabolic syndrome by any of the 3 definitions, and 38.3% fulfilled metabolic syndrome criteria for all 3 definitions. Ten percent of subjects were positive for metabolic syndrome based on NCEPas and IDF, but not for NCEPwe. Because IDF requires abdominal obesity as a criterion, the frequency of subjects without metabolic syndrome according to IDF, but with metabolic syndrome by NCEPwe and NCEPas was 8.2%. CONCLUSIONS: Independent of the metabolic syndrome definition, Japanese-Brazilians present an elevated metabolic syndrome prevalence, which was higher when using NCEP criteria for Asians, followed by the IDF definition for Japanese.
Assuntos
Povo Asiático , Síndrome Metabólica/etnologia , Síndrome Metabólica/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Povo Asiático/estatística & dados numéricos , Glicemia/análise , Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Brasil/epidemiologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etnologia , Doenças Cardiovasculares/etiologia , Colesterol/sangue , Etnicidade/classificação , Feminino , Humanos , Masculino , Síndrome Metabólica/complicações , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Obesidade Abdominal/complicações , Obesidade Abdominal/epidemiologia , Obesidade Abdominal/etnologia , Prevalência , Fatores de Risco , Circunferência da CinturaRESUMO
OBJECTIVE: We investigated whether lifestyle-induced changes in dietary fat quality are related to improvements on glucose metabolism disturbances in Japanese Brazilians at high risk of type 2 diabetes. METHODS: One hundred forty-eight first- and second-generation subjects with impaired glucose tolerance or impaired fasting glycemia who attended a lifestyle intervention program for 12 mo were studied in the city of Bauru, State of São Paulo, Brazil. Dietary fatty acid intakes at baseline and after 12 mo were estimated using three 24-h recalls. The effect of dietary fat intake on glucose metabolism was investigated by multiple logistic regression models. RESULTS: At baseline, mean +/- standard deviation age and body mass index were 60+/-11 y and 25.5+/-4.2kg/m(2), respectively. After 12 mo, 92 subjects had normal plasma glucose levels and 56 remained in prediabetic conditions. Using logistic regression models adjusted for age, gender, generation, basal intake of explanatory nutrient, energy intake, physical activity, and waist circumference, the odds ratios (95% confidence intervals) for reversion to normoglycemia were 3.14 (1.22-8.10) in the second tertile of total omega-3 fatty acid, 4.26 (1.34-13.57) in the second tertile of eicosapentaenoic acid, and 2.80 (1.10-7.10) in the second tertile of linolenic acid. Similarly, subjects in the highest tertile of omega-3:omega-6 fatty acid ratio showed a higher chance of improving glucose disturbances (2.51, 1.01-6.37). CONCLUSIONS: Our findings support the evidence of an independent protective effect of omega-3 fatty acid and of a higher omega-3:omega-6 fatty acid ratio on the glucose metabolism of high-risk individuals.
Assuntos
Glicemia , Dieta , Ácidos Graxos Ômega-3/administração & dosagem , Ácidos Graxos Ômega-6/administração & dosagem , Intolerância à Glucose/dietoterapia , Hiperglicemia/dietoterapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Registros de Dieta , Método Duplo-Cego , Ácido Eicosapentaenoico/administração & dosagem , Feminino , Intolerância à Glucose/etnologia , Humanos , Hiperglicemia/etnologia , Japão/etnologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Ácido alfa-Linolênico/administração & dosagemRESUMO
OBJETIVO: Avaliar o estado nutricional de crianças dos povos indígenas de famílias lingüísticas Aruak e Karibe do Alto Xingu, no Brasil Central, e verificar a associação entre os níveis de hemoglobina das crianças segundo sexo, idade e estado nutricional. Foram estudadas, no total, 470 crianças menores de dez anos de idade em 2001/2002. MÉTODOS: Para as crianças menores de cinco anos de idade, o diagnóstico de desnutrição foi realizado com base nos índices altura/idade e peso/altura, adotando-se como ponto de corte dois desvios-padrão aquém da média esperada para idade e sexo da referência - WHO, 2006. O diagnóstico de excesso de peso foi definido de acordo com o índice peso/altura acima de dois desvios-padrão da média esperada da mesma referência; as crianças com idade entre cinco e dez anos foram classificadas com baixo peso, sobrepeso ou obesidade de acordo com valores do índice de massa corporal, segundo sexo e idade, propostos por Cole e cols. O diagnóstico de anemia foi determinado a partir de concentrações de hemoglobina inferiores a 11,0 g/dL e inferiores a 11,5 g/dL para as crianças com idade entre 6 e 59 meses e entre 60 e 120 meses, respectivamente. RESULTADOS/CONCLUSÃO: Verificou-se entre as crianças indígenas elevada prevalência de déficit de estatura; a condição de baixo peso praticamente inexiste e o excesso de peso é expressivo entre as crianças mais novas e as de maior idade. A magnitude da anemia alcança cerca de 70 por cento e a idade parece ser o principal fator associado às baixas concentrações de hemoglobina.