RESUMO

A group of 102 Mexican Mestizo patients with appropriate clinical features suggestive of primary thrombophilia was prospectively studied. Thirty-nine percent of them had activated protein C resistance, but only four patients displayed the factor V Leiden mutation. Five percent of the individuals were found to be protein C deficient, whereas 2% had protein S deficiency. No cases of abnormalities in antithrombin III, plasminogen, tissue-type plasminogen activator or plasminogen activator inhibitor were found. The low prevalence of the activated protein C resistance genotype, probably stemming from the genetic admixture of the Mexican Mestizo group is noteworthy.

Assuntos

Trombose/epidemiologia , População Branca/genética , Resistência à Proteína C Ativada/epidemiologia , Resistência à Proteína C Ativada/etnologia , Resistência à Proteína C Ativada/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Humanos , Indígenas Norte-Americanos/genética , México/epidemiologia , Pessoa de Meia-Idade , Fenótipo , Prevalência , Estudos Prospectivos , Deficiência de Proteína C/epidemiologia , Deficiência de Proteína C/etnologia , Deficiência de Proteína S/epidemiologia , Deficiência de Proteína S/etnologia , Trombose/etnologia , Trombose/genética