RESUMO
Tumoral calcinosis anterior to the right knee in an infant is reported. The presence of tumoral calcinosis in young children is rare. The knee is considered to be a rare location for tumoral calcinosis.
Assuntos
Calcinose/diagnóstico por imagem , Joelho , Feminino , Humanos , Recém-Nascido , Joelho/diagnóstico por imagem , RadiografiaRESUMO
Oral chloral hydrate sedation in children is safely used prior to cross-sectional imaging. We report two children with Leigh's disease who developed acute respiratory insufficiency following high dose oral chloral hydrate sedation.
Assuntos
Encefalopatias Metabólicas/diagnóstico por imagem , Hidrato de Cloral/efeitos adversos , Doença de Leigh/diagnóstico por imagem , Insuficiência Respiratória/induzido quimicamente , Tomografia Computadorizada por Raios X , Pré-Escolar , Hidrato de Cloral/administração & dosagem , Feminino , Humanos , Lactente , MasculinoRESUMO
Low natural killer cytotoxicity has been associated with serious herpes simplex virus infections. Neonates' mononuclear cells had significantly lower NKC to HSV infected (P less than 0.001) and uninfected (P less than 0.005) target cells than did adults' MC. Under appropriate conditions, both neonates' MC to NKC was increased by exogenous human leukocyte interferon. Although neonates' and adults' MC had a similar sensitivity to interferon, there was a significant (P = 0.05) lack of consistency in neonates' MC response. Twenty-three percent (4/17) of neonates' MC samples did not respond with increased NKC in the presence of interferon, unlike adults' MC, all of which demonstrated increased NKC. Neonates' MC did not suppress adults' MC-NKC. These data demonstrate the efficacy of interferon as an NKC stimulator in the neonate, but indicate a heterogeneous response of neonatal cells. We are encouraged with the prospect of clinical trials of interferon to treat severe viral infections in neonates. We urge the inclusion of immune surveillance in these trials.
Assuntos
Recém-Nascido , Interferons/farmacologia , Células Matadoras Naturais/efeitos dos fármacos , Adulto , Citotoxicidade Celular Dependente de Anticorpos/efeitos dos fármacos , Relação Dose-Resposta a Droga , Herpes Simples/patologia , Humanos , Estimulação QuímicaRESUMO
We present two successfully treated cases of amebic peritonitis. Acute peritonitis secondary to intra-abdominal rupture of an amebic liver abscess is an infrequent but serious complication of invasive amebiasis. Its diagnosis should be considered in anyone with a suspected liver abscess, jaundice, or diarrhea in whom peritonitis develops. This diagnosis should be further suggested in the United States if the patient is a male and is of Mexican origin in areas where this racial group constitutes the majority of cases of amebic disease. Use of radioisotope liver scans and the demonstration of serum precipitins to Endamoeba histolytica may provide rapid evidence of invasive disease, although surgical intervention is often necessary to make a specific diagnosis. Emetine hydrochloride alone or followed by metronidazole combined with surgical drainage is the current treatment for amebic peritonitis.