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INTRODUCTION: Candidemia, a bloodstream infection predominantly affecting critically ill patients, poses a significant global health threat especially with the emergence of non-albicans Candida species, including drug-resistant strains. In Brazil, limited access to advanced diagnostic tools and trained microbiologists hampers accurate identification of Candida species and susceptibility to antifungals testing hindering surveillance efforts. METHODS: We conducted a systematic review spanning publications from 2017 to 2023 addressing Candida species distribution and antifungal susceptibility among Brazilian patients with candidemia. RESULTS: Despite initially identifying 7075 records, only 16 met inclusion criteria providing accurate information of 2305 episodes of candidemia. The predominant species were C. albicans, C. parapsilosis, and C. tropicalis, followed by notable proportions of Nakaseomyces glabratus. Limited access to diagnostic tests was evident as only 5 out of 16 studies on candidemia were able to report antifungal susceptibility testing results. In vitro resistance to echinocandins was rare (only 6/396 isolates, 1,5%). In counterpart, fluconazole exhibited resistance rates ranging from 0 to 43%, with great heterogeneity among different studies and species of Candida considered. CONCLUSION: Our review underscores the critical need for enhanced surveillance and research efforts to address the evolving landscape of candidemia and antifungal resistance in Brazil. Despite some limitations, available data suggest that while resistance to echinocandins and amphotericin B remains rare, there is a growing concern regarding resistance to fluconazole among Candida species.

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Apresentamos uma discussão sobre a produção bibliográfica em Ciências Sociais e Humanas em Saúde (CSHS) publicada pela Revista Interface nos últimos vinte anos (1997-2017). Buscamos descrever o processo de legitimação das CSHS por meio da divulgação de saberes teórico-metodológicos e de temáticas específicas no conjunto da produção científica nacional. Foram consultadas todas as publicações do período e selecionados 216 artigos identificados com as CSHS. A análise resultou em categorias que evidenciaram os seguintes temas: saúde mental, envelhecimento, doenças infectocontagiosas, gênero, saúde reprodutiva e teórico-conceitual. A conjunção dos temas com problemas contemporâneos da sociedade brasileira revela autores como protagonistas de estudos de relevância social e comprometimento político com as transformações e mudanças ocorridas tanto no plano do cuidado em saúde quanto no das políticas públicas.(AU)

We present a discussion about the bibliographic production in Social and Human Sciences in Health (SHSH) published by the journal Interface in the last twenty years (1997-2017). We aim to describe the legitimation process of the SHSH by disseminating theoretical and methodological knowledge and specific themes within the Brazilian scientific production. All the publications of the period were consulted and 216 articles identified with the SHSH were selected. The analysis resulted in categories that highlighted the following themes: mental health, aging, infectious diseases, gender, reproductive health, and theoretical-conceptual. The combination of the themes with current problems of the Brazilian society reveals authors as protagonists of studies that have social relevance and political commitment to transformations and changes occurring both in health care and in public policies.(AU)

Presentamos una discusión sobre la producción bibliográfica en Ciencias Sociales y Humanas en Salud (CSHS) publicada por la revista Interface en los últimos veinte años (1997-2017). Buscamos describir el proceso de legitimización de las CSHS por medio de la divulgación de saberes teórico-metodológicos y de temáticas específicas en el conjunto de la producción científica nacional. Se consultaron todas las publicaciones del período y se seleccionaron 216 artículos identificados con las CSHS. El análisis resultó en categorías que dejaron en evidencia los siguientes temas: salud mental, envejecimiento, enfermedades infectocontagiosas, género, salud reproductiva y teórico-conceptual. La conjunción de los temas con problemas contemporáneos de la sociedad brasileña revela autores como protagonistas de estudios de relevancia social y compromiso político con las transformaciones y cambios habidos tanto en el plano del cuidado en salud como en el de las políticas públicas.(AU)

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