Assuntos
Frutas/intoxicação , Vômito/etiologia , Plantas , Plantas Comestíveis , Hipoglicinas/intoxicaçãoRESUMO
Two peptides, hypoglycin A (a neutral compound, m.p. 280-284§; [O][32][D]+9.2ñ2§) and hypoglycin B(an acid, double m.p. 194-195§, 200-206§; [O][32][D]+9.6ñ2§; neutralization equiv. 175) have been isolated from the unripe seeds of Bhighia sapida. The aqueous extract of the seeds, which contains some fourteen ninhydrin-positive compounds in addition to hypoglycin A and B, was fractionated by means of the Amberlite ion-exchange resins IR-120, IRC-50 and IR-4B. The isolation of hypoglycin A and B was followed by toxicity tests using kittens and albino rats. The hypoglycaemic activity of the peptides is circumstantial evidence of a connection between the Jamaican disease 'vomiting sickness' and the practice of eating the fruit Blighia sapida. Hypoglycin A, but not hypoglycin B, occurs in the arillus of the fruit. The unripe arillus contains a very much higher concentration of hypoglycin A than the ripe arillus. (Summary)
Assuntos
Hipoglicinas/análise , Hipoglicinas/isolamento & purificação , Frutas/intoxicação , Frutas/toxicidade , JamaicaRESUMO
Urechitoxin C[38]H[58]O[14], isolated from leaves of Urechites suberecta in which enzymic hydrolysis is inhibited, is formulated as glucosido-oleandrin. When enzymic hydrolysis is permitted, deacetylanhydro-oleandrin and oleandrin are obtained. (AU)