RESUMO

TACROLIMUS, a mainstay of immunosuppression after orthotopic heart transplantation (OHT), is associated with a broad range of side effects. Vasoconstriction caused by tacrolimus has been proposed as a mechanism underlying common side effects such as hypertension and renal injury. Neurologic side effects attributed to tacrolimus include headaches, posterior reversible encephalopathy syndrome (PRES), or reversible cerebral vasospasm syndrome (RCVS). Six case reports have been published describing RCVS in the setting of tacrolimus administration after OHT. The authors report a case of perfusion-dependent focal neurologic deficits attributed to tacrolimus-induced RCVS in an OHT recipient.

Assuntos

Transplante de Coração , Síndrome da Leucoencefalopatia Posterior , Vasoespasmo Intracraniano , Humanos , Tacrolimo/efeitos adversos , Vasoespasmo Intracraniano/induzido quimicamente , Vasoespasmo Intracraniano/diagnóstico por imagem , Síndrome da Leucoencefalopatia Posterior/induzido quimicamente , Síndrome da Leucoencefalopatia Posterior/diagnóstico por imagem , Estado Terminal , Perfusão/efeitos adversos , Transplante de Coração/efeitos adversos