RESUMO
BACKGROUND: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. OBJECTIVE: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. METHODS: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. RESULTS: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. CONCLUSION: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified.
RESUMO
Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. .
Assuntos
Humanos , Alergia e Imunologia , Transfusão de Sangue , Transfusão de Sangue Autóloga , Proteína C-Reativa , Transfusão de Eritrócitos , Isoanticorpos/sangue , Neoplasias , Fenômenos do Sistema ImunitárioRESUMO
OBJECTIVES: To analyze trends in morbidity due to respiratory diseases, using hospital admissions in the city of São Paulo from 1995 to 2000. To describe the evolution of the morbidity for respiratory diseases in general and for pneumonias, for asthma and for chronic obstructive pulmonary disease (COPD), by sex and age. METHODS: The information on hospital admissions for all ages and causes were obtained from the Hospitalizations Information System of the Brazilian Ministry of Health (DATASUS). Descriptive analysis of patterns and trends were performed. RESULTS: There was a decreasing trend in the absolute number and the rate of hospitalization for respiratory illnesses for all ages but not uniformly during the period. For COPD, an increasing trend was observed, especially for the elderly. The male population was more affected than the female in all years, for any studied causes with the exception of asthma. The pneumonias represented the most important cause of hospitalizations, with 47% of all respiratory admissions. Important seasonal pattern was observed for pneumonia admissions. CONCLUSION: In this period of 6 years, our analyses had disclosed an important participation of pneumonias as a cause for respiratory admissions. However, these diseases presented a decreasing trend, in contrast to chronic illnesses such as COPD and asthma. These results point out to a changing pattern in the respiratory morbidity with direct consequences for public health policy making.
Assuntos
Asma/epidemiologia , Hospitalização/estatística & dados numéricos , Pneumonia/epidemiologia , Doença Pulmonar Obstrutiva Crônica/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Brasil/epidemiologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Doenças Respiratórias/epidemiologia , Distribuição por SexoRESUMO
OBJETIVOS: Analisar a morbidade por doencas respiratórias, medida pelas internacões hospitalares, no município de São Paulo de 1995 a 2000, descrevendo o comportamento das internacões por doencas respiratórias totais, pneumonias, asma e doenca pulmonar obstrutiva crônica (DPOC), conforme sexo e idade, e identificar suas tendências. MÉTODOS: As informacões referentes às internacões hospitalares, para todas as idades e causas, foram obtidas através das Autorizacões de Internacões Hospitalares do SUS - Ministério da Saúde (DATASUS). Foi realizada análise descritiva com gráficos e tabelas. RESULTADOS: Houve decréscimo no número absoluto e na taxa de internacões por doencas respiratórias totais em todas as idades, mas de maneira não uniforme em todo o período. Para DPOC, observou-se tendência de aumento importante, principalmente entre os idosos. A populacão masculina foi mais afetada do que a feminina em todos os anos, por quaisquer causas estudadas, com excecão da asma. As pneumonias representaram a causa mais importante de hospitalizacões, com 47 por cento das internacões. As internacões, principalmente das pneumonias, apresentaram padrão sazonal marcante. CONCLUSAO: Neste período de seis anos, nossas análises revelaram a participacão importante das pneumonias como causa de internacão. Porém, estas doencas vêm apresentando uma tendência decrescente, ao contrário de doencas crônicas como a DPOC e a asma. Estes resultados indicam uma ligeira mudanca no perfil destas doencas no nosso meio, o que traz conseqüências imediatas para o planejamento de servicos e para a formulacão de políticas de saúde.
Assuntos
Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Asma/mortalidade , Hospitalização/estatística & dados numéricos , Pneumonia/mortalidade , Doença Pulmonar Obstrutiva Crônica/mortalidade , Distribuição por Idade , Brasil/epidemiologia , Distribuição por SexoRESUMO
Doencas respiratorias sao importante causa de morbi-mortalidade em todas as faixas etarias, com consideravel impacto...