RESUMO

We examined the frequency of RsaI polymorphism of the ERß gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ERß gene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG polymorphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG. The frequency of heterozygous AG was nine times higher in patients with endometriosis than in the control group (P < 0.0001).

Assuntos

Desoxirribonucleases de Sítio Específico do Tipo II/metabolismo , Endometriose/genética , Receptor beta de Estrogênio/genética , Polimorfismo Genético , Adulto , Endometriose/enzimologia , Receptor beta de Estrogênio/metabolismo , Feminino , Humanos