RESUMO

Administration of cyclosporine resulted in reduced insulin requirements and improved glycemic control in patients with insulin-dependent diabetes mellitus of recent onset, but the drug was less effective in young children. Renal toxic effects and other problems related to therapy resolved after discontinuation of the drug. Sustained remission seemed dependent on continued administration of cyclosporine. Although short-term control of diabetes may be achieved in some patients, more studies are needed to determine whether cyclosporine can be given safely as maintenance therapy to maintain glycemic control and prevent the long-term consequences of the disease.

Assuntos

Doenças Autoimunes/tratamento farmacológico , Ciclosporinas/uso terapêutico , Diabetes Mellitus Tipo 1/tratamento farmacológico , Adolescente , Adulto , Fatores Etários , Autoanticorpos/análise , Criança , Pré-Escolar , Ciclosporinas/efeitos adversos , Avaliação de Medicamentos , Teste de Tolerância a Glucose , Humanos , Lactente , Insulina/administração & dosagem , Ilhotas Pancreáticas/imunologia , Nefropatias/induzido quimicamente , Pessoa de Meia-Idade , Fatores de Tempo