RESUMO
We present here a case of localised primary amyloidosis of the right inguinal lymph node in a 42 year old female. On gross examination the specimen was 4.0 x 4.0 x 3.2 cm in size with a tan-pink color and two whitish-yellow areas of hard consistency. Histologically the lymph node was replaced by an eosinophilic amorphous material, alkaline Congo red, crystal violet, thioflavine T and sodium sulphate-alcian blue (SAB). We observed areas of mature bone metaplasia alternating with sheets of plasma cells and clusters of foreign body giant cell reaction. Immunohistochemical study showed anti-lambda chain staining within the amorphous material. The negative clinical history, physical examination, normal serum electrophoresis and bone marrow and rectal biopsy allowed us to make the diagnosis of localised primary amyloidosis of lymph node. The patient is alive and without evidence of disease progression to systemic amyloidosis or plasma cell dyscrasia, after clinical follow-up of seven years.
Assuntos
Amiloidose/patologia , Osso e Ossos/patologia , Linfonodos/patologia , Doenças Linfáticas/patologia , Adulto , Amiloide/análise , Amiloidose/complicações , Feminino , Seguimentos , Virilha , Humanos , Técnicas Imunoenzimáticas , Linfonodos/química , Doenças Linfáticas/complicações , MetaplasiaRESUMO
We present 23 cases of latent thyroid carcinoma which were examined in 356 surgical specimens (incidence: 6.4%), having found a sclerosing variant predominance. Of the total cases that were under study, twenty of them belonged to women (86%), and three to men (14%). Due to the fact that the concepts of latent thyroid carcinoma and occult thyroid carcinoma are often misused as synonyms, regarding both pathologies, we have carefully examined the available literature and therefore, we have made a critic analysis of both entities. We also made a detailed microscopic study of the surgical specimens and included a slice for histopathologic examination, which was evaluated every 5 g of tissue. The purpose of this last study responded to our consideration on the real incidence of latent thyroid carcinoma, which cannot be found in routine studies.